ID   RT106_CANAL             Reviewed;         409 AA.
AC   Q59S27; A0A1D8PPA4; Q59RM6;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Histone chaperone RTT106;
GN   Name=RTT106; OrderedLocusNames=CAALFM_C600190WA;
GN   ORFNames=CaO19.1177, CaO19.8769;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Histones H3 and H4 chaperone involved in the nucleosome
CC       formation and heterochromatin silencing. Required for the deposition of
CC       H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role
CC       in the transcriptional regulation of the cell-cycle dependent histone
CC       genes by creating a repressive structure at the core histone gene
CC       promoter (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with histones H3 and H4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RTT106 family. {ECO:0000305}.
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DR   EMBL; CP017628; AOW29969.1; -; Genomic_DNA.
DR   RefSeq; XP_712295.2; XM_707202.2.
DR   AlphaFoldDB; Q59S27; -.
DR   SMR; Q59S27; -.
DR   STRING; 237561.Q59S27; -.
DR   GeneID; 3646080; -.
DR   KEGG; cal:CAALFM_C600190WA; -.
DR   CGD; CAL0000189137; orf19.8769.
DR   VEuPathDB; FungiDB:C6_00190W_A; -.
DR   HOGENOM; CLU_040939_0_0_1; -.
DR   InParanoid; Q59S27; -.
DR   OMA; TRLTFNV; -.
DR   OrthoDB; 1283058at2759; -.
DR   PRO; PR:Q59S27; -.
DR   Proteomes; UP000000559; Chromosome 6.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0031491; F:nucleosome binding; IBA:GO_Central.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR013719; DUF1747.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR040770; Rtt106_PH.
DR   Pfam; PF18469; PH_18; 1.
DR   Pfam; PF08512; Rtt106; 1.
DR   SMART; SM01287; Rtt106; 1.
PE   3: Inferred from homology;
KW   Chaperone; Chromosome; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..409
FT                   /note="Histone chaperone RTT106"
FT                   /id="PRO_0000320487"
FT   REGION          344..409
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        360..387
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        389..409
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   409 AA;  46233 MW;  54594656B06DEACF CRC64;
     MDSAWVQQLP PELQNDIKAV VEKDQSSFAA FDNLHAFLTG GTTKKRKLNA EPEEIPPETI
     IFEINEISFY SPVRKRMNLT LHLVEEDGNP SPALSIVNPS NNIPELTFTG LDQAVKLCLL
     LPILGNTTNT QKKAICYLCF WMHDENMSKD PIVCQMNLDL VKKSMIKNGK LPADIESKFI
     TPRDALPLNP IQERIIDYFK RQFQLCGISM MNYMPCVSIF RNTFSLNDDN AIAMNTDGAS
     QPALVMVNCH KGAKEGVLIL LQANKTNPAH IIFGFKKPIL VFEASQVLHT SYSNITRQTF
     SLNVVVLNKK QEQRELEFGM IDEKFYKVID DFIKLQGIND ATFNQEESGD DSIEIVHVNN
     NDDDDDEEDD DFQSEDSGSD VEEEYNSDLN EPLAAHEEDG VFERGIEIE