ID   RT106_CANGA             Reviewed;         453 AA.
AC   Q6FRJ6;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Histone chaperone RTT106;
GN   Name=RTT106; OrderedLocusNames=CAGL0H08041g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Histones H3 and H4 chaperone involved in the nucleosome
CC       formation and heterochromatin silencing. Required for the deposition of
CC       H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role
CC       in the transcriptional regulation of the cell-cycle dependent histone
CC       genes by creating a repressive structure at the core histone gene
CC       promoter (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with histones H3 and H4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RTT106 family. {ECO:0000305}.
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DR   EMBL; CR380954; CAG60081.1; -; Genomic_DNA.
DR   RefSeq; XP_447148.1; XM_447148.1.
DR   AlphaFoldDB; Q6FRJ6; -.
DR   SMR; Q6FRJ6; -.
DR   STRING; 5478.XP_447148.1; -.
DR   EnsemblFungi; CAG60081; CAG60081; CAGL0H08041g.
DR   GeneID; 2888512; -.
DR   KEGG; cgr:CAGL0H08041g; -.
DR   CGD; CAL0131910; CAGL0H08041g.
DR   VEuPathDB; FungiDB:CAGL0H08041g; -.
DR   eggNOG; ENOG502R9PE; Eukaryota.
DR   HOGENOM; CLU_040939_1_0_1; -.
DR   InParanoid; Q6FRJ6; -.
DR   OMA; TRLTFNV; -.
DR   Proteomes; UP000002428; Chromosome H.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0042393; F:histone binding; IEA:EnsemblFungi.
DR   GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR   GO; GO:0006335; P:DNA replication-dependent chromatin assembly; IEA:EnsemblFungi.
DR   GO; GO:0006336; P:DNA replication-independent chromatin assembly; IEA:EnsemblFungi.
DR   GO; GO:0031507; P:heterochromatin assembly; IEA:EnsemblFungi.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   CDD; cd11604; RTT106_N; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   Gene3D; 6.10.10.70; -; 1.
DR   InterPro; IPR013719; DUF1747.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR040993; Rtt106_N.
DR   InterPro; IPR044891; Rtt106_N_sf.
DR   InterPro; IPR040770; Rtt106_PH.
DR   Pfam; PF18469; PH_18; 1.
DR   Pfam; PF08512; Rtt106; 1.
DR   Pfam; PF18215; Rtt106_N; 1.
DR   SMART; SM01287; Rtt106; 1.
PE   3: Inferred from homology;
KW   Chaperone; Chromosome; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..453
FT                   /note="Histone chaperone RTT106"
FT                   /id="PRO_0000320488"
FT   REGION          299..426
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        307..335
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        337..395
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        398..424
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   453 AA;  51392 MW;  0E4A9C93A4E18BBE CRC64;
     MSSFDFLNEL PKELQNKIRN ITRALPSSLE VFQELYNYGL SHSDNIEKKR KVTSNGVIDE
     QNIIFSLKNV SVLSPIRKKL DLVLHLSSID HKPQLSLVKN GVSEFSISNL KDNVKMGTFL
     PVPEKPNLLY LFVQLKKVND KDQDPILLTM NKENVLTEFK SMGLIGQEVD DFNKCTEYIR
     KQAILTGFKI ANPFNPSVEQ PVPSFHVECH RGTKEGTLYF LPEIIIFGFK KPILVFESSN
     IESISYSSIT RLTFNVTLIK KVDDGYGTKF EFSMIDQTEY SKIDDYVKLK QVKDESMSEE
     LKAKTANKNK QQNNTSDQPS ALQEATKQME TEGNINEIPF DSEDDEEADG NFEDNSDLSD
     GSEVEEEDNE EENEEDEEAD GGDYAEEDFE EDEIIQEQAN PAVNQLISKT TPINKNSSNA
     GLFDFPIETP SFDIPIELED NEDDEEGSGV EYD