ID   RT106_CHAGB             Reviewed;         464 AA.
AC   Q2H3D0;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Histone chaperone RTT106;
GN   Name=RTT106; ORFNames=CHGG_03716;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: Histones H3 and H4 chaperone involved in the nucleosome
CC       formation and heterochromatin silencing. Required for the deposition of
CC       H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role
CC       in the transcriptional regulation of the cell-cycle dependent histone
CC       genes by creating a repressive structure at the core histone gene
CC       promoter (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with histones H3 and H4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RTT106 family. {ECO:0000305}.
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DR   EMBL; CH408032; EAQ87097.1; -; Genomic_DNA.
DR   RefSeq; XP_001222930.1; XM_001222929.1.
DR   AlphaFoldDB; Q2H3D0; -.
DR   SMR; Q2H3D0; -.
DR   STRING; 38033.XP_001222930.1; -.
DR   EnsemblFungi; EAQ87097; EAQ87097; CHGG_03716.
DR   GeneID; 4391768; -.
DR   eggNOG; ENOG502R9PE; Eukaryota.
DR   HOGENOM; CLU_033828_0_0_1; -.
DR   InParanoid; Q2H3D0; -.
DR   OMA; AMPEAHR; -.
DR   OrthoDB; 1283058at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR013719; DUF1747.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   Pfam; PF08512; Rtt106; 1.
DR   SMART; SM01287; Rtt106; 1.
PE   3: Inferred from homology;
KW   Chaperone; Chromosome; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..464
FT                   /note="Histone chaperone RTT106"
FT                   /id="PRO_0000320489"
FT   REGION          382..464
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        411..464
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   464 AA;  50609 MW;  7023236B38DC2219 CRC64;
     MATQLDVQTL RSVFQSRPDI LSNIERNADT PARTTLFNEI ASFVYERLGS ADPEDGPASK
     RRRIDIAQLP THPQPNGHAH GRAPPAGLSV DVAATDPVLL ELRDISVTAP QRKKYDLCFT
     KNFLYARASG TSVPVQGVVY PLKDIEHAFY LPVPDKSQAQ YNYVLLPRDS YLPTAKQAGA
     NSGGGLQPLE PLVFTVPAAA PKPGSVVGPS SAAAEAVSDT YSSLLHWALT TSMRSAGNHS
     CQLVASDPKL FHSVARQPHR PNEKAVHVKA FRGSKDGFLF FLPTGILWGF KKPILFLPLD
     RIVAVSYTNV LRTTFNIVVE LDTDIPGEAN IAIEKEIEFG MIDQEDYGGI DETYVRRHGL
     ADRSMAEQRK AKRELVENIK KPAAGDELAG GEGDADGLTA LERAQREAEQ QLQDEEDEME
     EDYDPGSEGD SEGEGGSSGE DDDDDEAQGD YDDEEDDEAE GLEN