ID   RT106_COCIM             Reviewed;         455 AA.
AC   Q1E076; J3KD28;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Histone chaperone RTT106;
GN   Name=RTT106; ORFNames=CIMG_04037;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Histones H3 and H4 chaperone involved in the nucleosome
CC       formation and heterochromatin silencing. Required for the deposition of
CC       H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role
CC       in the transcriptional regulation of the cell-cycle dependent histone
CC       genes by creating a repressive structure at the core histone gene
CC       promoter (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with histones H3 and H4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RTT106 family. {ECO:0000305}.
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DR   EMBL; GG704916; EAS33013.3; -; Genomic_DNA.
DR   RefSeq; XP_001244596.1; XM_001244595.2.
DR   AlphaFoldDB; Q1E076; -.
DR   SMR; Q1E076; -.
DR   STRING; 246410.Q1E076; -.
DR   EnsemblFungi; EAS33013; EAS33013; CIMG_04037.
DR   GeneID; 4563413; -.
DR   KEGG; cim:CIMG_04037; -.
DR   VEuPathDB; FungiDB:CIMG_04037; -.
DR   InParanoid; Q1E076; -.
DR   OMA; AMPEAHR; -.
DR   OrthoDB; 1283058at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR013719; DUF1747.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   Pfam; PF08512; Rtt106; 1.
DR   SMART; SM01287; Rtt106; 1.
PE   3: Inferred from homology;
KW   Chaperone; Chromosome; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..455
FT                   /note="Histone chaperone RTT106"
FT                   /id="PRO_0000320490"
FT   REGION          51..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          371..455
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        51..69
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        377..397
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        398..431
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        432..448
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   455 AA;  50306 MW;  61D168E6D56F2270 CRC64;
     MGFVSVNNSQ IINKAFGPNQ PLQQRIYQAL AASPDLRPLF EDIAKYTSDL QDATSNAAAP
     PQPSRSQAQP VLGEGPAPKK RKIANGGDSI RSSSALAGMT QDADLQIYVQ DMSFAVPQRK
     KLQLEITRAP GNVEYLRARN QALNMIEFGV PFPKIQHVLC LPVPEKSQKQ FNFCIIPEGN
     DGISAAKPGE PVYETIVWTV PDGPPRTAFL GSGTPAMEGA SLAETYQGYL QSILDEKLKH
     TRVICPDEKE FVSAIPEPHR KGEKAFHVKA FRGSKEGYMF LLSTGIFFGF KKPLIFFAFD
     NIESISYTSV LQRTFNLNIL TRSSTNPDHM QEFELSMIDQ ADYPGIDAYV KKHRLQDASL
     VEARRAKSLN INGEKGENQE AHAEGTESEL LKAQRELEDQ EDEEEEDYDP GSDGDSDGSG
     TSSEEEDDHY GDEDHGEGRN LVKEELGSEA EDVEV