RT106_COCIM
ID RT106_COCIM Reviewed; 455 AA.
AC Q1E076; J3KD28;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 1.
DT 25-MAY-2022, entry version 67.
DE RecName: Full=Histone chaperone RTT106;
GN Name=RTT106; ORFNames=CIMG_04037;
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS;
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=RS;
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- FUNCTION: Histones H3 and H4 chaperone involved in the nucleosome
CC formation and heterochromatin silencing. Required for the deposition of
CC H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role
CC in the transcriptional regulation of the cell-cycle dependent histone
CC genes by creating a repressive structure at the core histone gene
CC promoter (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with histones H3 and H4. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RTT106 family. {ECO:0000305}.
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DR EMBL; GG704916; EAS33013.3; -; Genomic_DNA.
DR RefSeq; XP_001244596.1; XM_001244595.2.
DR AlphaFoldDB; Q1E076; -.
DR SMR; Q1E076; -.
DR STRING; 246410.Q1E076; -.
DR EnsemblFungi; EAS33013; EAS33013; CIMG_04037.
DR GeneID; 4563413; -.
DR KEGG; cim:CIMG_04037; -.
DR VEuPathDB; FungiDB:CIMG_04037; -.
DR InParanoid; Q1E076; -.
DR OMA; AMPEAHR; -.
DR OrthoDB; 1283058at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR013719; DUF1747.
DR InterPro; IPR011993; PH-like_dom_sf.
DR Pfam; PF08512; Rtt106; 1.
DR SMART; SM01287; Rtt106; 1.
PE 3: Inferred from homology;
KW Chaperone; Chromosome; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..455
FT /note="Histone chaperone RTT106"
FT /id="PRO_0000320490"
FT REGION 51..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 371..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..397
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..431
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..448
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 455 AA; 50306 MW; 61D168E6D56F2270 CRC64;
MGFVSVNNSQ IINKAFGPNQ PLQQRIYQAL AASPDLRPLF EDIAKYTSDL QDATSNAAAP
PQPSRSQAQP VLGEGPAPKK RKIANGGDSI RSSSALAGMT QDADLQIYVQ DMSFAVPQRK
KLQLEITRAP GNVEYLRARN QALNMIEFGV PFPKIQHVLC LPVPEKSQKQ FNFCIIPEGN
DGISAAKPGE PVYETIVWTV PDGPPRTAFL GSGTPAMEGA SLAETYQGYL QSILDEKLKH
TRVICPDEKE FVSAIPEPHR KGEKAFHVKA FRGSKEGYMF LLSTGIFFGF KKPLIFFAFD
NIESISYTSV LQRTFNLNIL TRSSTNPDHM QEFELSMIDQ ADYPGIDAYV KKHRLQDASL
VEARRAKSLN INGEKGENQE AHAEGTESEL LKAQRELEDQ EDEEEEDYDP GSDGDSDGSG
TSSEEEDDHY GDEDHGEGRN LVKEELGSEA EDVEV