ID   RT106_DEBHA             Reviewed;         482 AA.
AC   Q6BYP2;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Histone chaperone RTT106;
GN   Name=RTT106; OrderedLocusNames=DEHA2A07986g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Histones H3 and H4 chaperone involved in the nucleosome
CC       formation and heterochromatin silencing. Required for the deposition of
CC       H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role
CC       in the transcriptional regulation of the cell-cycle dependent histone
CC       genes by creating a repressive structure at the core histone gene
CC       promoter (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with histones H3 and H4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RTT106 family. {ECO:0000305}.
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DR   EMBL; CR382133; CAG84633.2; -; Genomic_DNA.
DR   RefSeq; XP_456677.2; XM_456677.1.
DR   AlphaFoldDB; Q6BYP2; -.
DR   SMR; Q6BYP2; -.
DR   STRING; 4959.XP_456677.2; -.
DR   PRIDE; Q6BYP2; -.
DR   EnsemblFungi; CAG84633; CAG84633; DEHA2A07986g.
DR   GeneID; 2899653; -.
DR   KEGG; dha:DEHA2A07986g; -.
DR   VEuPathDB; FungiDB:DEHA2A07986g; -.
DR   eggNOG; ENOG502R9PE; Eukaryota.
DR   HOGENOM; CLU_040939_0_0_1; -.
DR   InParanoid; Q6BYP2; -.
DR   OMA; TRLTFNV; -.
DR   OrthoDB; 1283058at2759; -.
DR   Proteomes; UP000000599; Chromosome A.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR013719; DUF1747.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR040770; Rtt106_PH.
DR   Pfam; PF18469; PH_18; 1.
DR   Pfam; PF08512; Rtt106; 1.
DR   SMART; SM01287; Rtt106; 1.
PE   3: Inferred from homology;
KW   Chaperone; Chromosome; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..482
FT                   /note="Histone chaperone RTT106"
FT                   /id="PRO_0000320491"
FT   REGION          47..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          390..482
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        47..64
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        405..456
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   482 AA;  53386 MW;  D5D87974761F4226 CRC64;
     MSNDQKWIKS LPSDLQNQVN ALVEAHPPSL TVIHKLCEYF KTNASEHEDK RRKLSSDPEI
     KSEGHVPEAL SGPKSEVPGQ IHEQEIIFEL PQISFQSPIR KKLNLIFHLL VEPGQSPKPV
     MSLALPTTYV PEISIHNLAS SIRLCVLLPI LGNSTNNTKR NIGLLCFWIH DDAASDPNKN
     DPIICQVNFD QVKKQLIKAG KIPAEAETQL KEMNESNQSQ DGIKAINEAI INFLQKQFQL
     CGIHMINYLP SSSATKNKLT INTDAGVAVS SNANSVNDLV MVEAYKGARD GAVLMLTANE
     YNQPYIIFGF KKPILIFDIS KVQHVSYSNI TRLTYSMIVT VVNEKKDSKV ETLEFGMIDQ
     KYFQIMDEFI KSQGINDNSF DEDLREKVTT NANSGEGEQA SEQAAPADSD DEEEDGTFQV
     GQEEEGESSV DEEYDSNAGS DGDSDVGEEE DDTNENNEGA NPAASTEADD VVTQSKEEDD
     EQ