ID   RT106_KLULA             Reviewed;         459 AA.
AC   Q6CQ86;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Histone chaperone RTT106;
GN   Name=RTT106; OrderedLocusNames=KLLA0D18986g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Histones H3 and H4 chaperone involved in the nucleosome
CC       formation and heterochromatin silencing. Required for the deposition of
CC       H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role
CC       in the transcriptional regulation of the cell-cycle dependent histone
CC       genes by creating a repressive structure at the core histone gene
CC       promoter (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with histones H3 and H4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RTT106 family. {ECO:0000305}.
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DR   EMBL; CR382124; CAH00999.1; -; Genomic_DNA.
DR   RefSeq; XP_453903.1; XM_453903.1.
DR   AlphaFoldDB; Q6CQ86; -.
DR   SMR; Q6CQ86; -.
DR   STRING; 28985.XP_453903.1; -.
DR   EnsemblFungi; CAH00999; CAH00999; KLLA0_D18986g.
DR   GeneID; 2892814; -.
DR   KEGG; kla:KLLA0_D18986g; -.
DR   eggNOG; ENOG502R9PE; Eukaryota.
DR   HOGENOM; CLU_040939_1_0_1; -.
DR   InParanoid; Q6CQ86; -.
DR   OMA; TRLTFNV; -.
DR   Proteomes; UP000000598; Chromosome D.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0042393; F:histone binding; IEA:EnsemblFungi.
DR   GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR   GO; GO:0006335; P:DNA replication-dependent chromatin assembly; IEA:EnsemblFungi.
DR   GO; GO:0006336; P:DNA replication-independent chromatin assembly; IEA:EnsemblFungi.
DR   GO; GO:0031507; P:heterochromatin assembly; IEA:EnsemblFungi.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   CDD; cd11604; RTT106_N; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   Gene3D; 6.10.10.70; -; 1.
DR   InterPro; IPR013719; DUF1747.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR040993; Rtt106_N.
DR   InterPro; IPR044891; Rtt106_N_sf.
DR   InterPro; IPR040770; Rtt106_PH.
DR   Pfam; PF18469; PH_18; 1.
DR   Pfam; PF08512; Rtt106; 1.
DR   Pfam; PF18215; Rtt106_N; 1.
DR   SMART; SM01287; Rtt106; 1.
PE   3: Inferred from homology;
KW   Chaperone; Chromosome; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..459
FT                   /note="Histone chaperone RTT106"
FT                   /id="PRO_0000320493"
FT   REGION          289..459
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        300..316
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        326..396
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        402..416
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        441..459
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   459 AA;  52711 MW;  36CC794FA76D6FF7 CRC64;
     MPNFLEKLSE SLREKVLHIV SKEPDSISIF QEVYNCGKDS QDEDIDNKKR KLTTTDTLSV
     NDENVVFELQ DVSVLSPLRK KLTVLIAVDE RDQSPMISFN KNNNVEYVIN NIKQSVKFST
     FLPFPEKKNL VYLYMNYERD GSNADPVLIT LNKEQILKQF KERNLLKAED SDFQLCVDYM
     RRQAILTGFR ISDPFSKSVM DSHHSFFVDC HRGSKEGTLF FLPEHIIFGF KKPILLFESK
     QIDAITYSSI TRLTFNVTLI TKDGERFEFS MIDQNKFSEI DEYVKKKQVE DKSMSDELKA
     KTPKSGQTSD QSALKEALEE SGTLDTMNGE SDDEDDQNFE EESDLSDGSG SGDDDEDDDD
     DDDDEDDDSI EKGDDGEEEE DDNEEEEQEE EEKEEQEQEQ NRQILNRASP NAAPSNHFSM
     EIDEIPDLLD ENGLIQDIPI TMDDDNDEEE EEGSGVEYD