ID   RT106_LODEL             Reviewed;         492 AA.
AC   A5E4Y7;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Histone chaperone RTT106;
GN   Name=RTT106; ORFNames=LELG_04676;
OS   Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS   1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC   Lodderomyces.
OX   NCBI_TaxID=379508;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL
RC   YB-4239;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Histones H3 and H4 chaperone involved in the nucleosome
CC       formation and heterochromatin silencing. Required for the deposition of
CC       H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role
CC       in the transcriptional regulation of the cell-cycle dependent histone
CC       genes by creating a repressive structure at the core histone gene
CC       promoter (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with histones H3 and H4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RTT106 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH981530; EDK46495.1; -; Genomic_DNA.
DR   RefSeq; XP_001523863.1; XM_001523813.1.
DR   AlphaFoldDB; A5E4Y7; -.
DR   SMR; A5E4Y7; -.
DR   STRING; 379508.A5E4Y7; -.
DR   EnsemblFungi; EDK46495; EDK46495; LELG_04676.
DR   GeneID; 5231208; -.
DR   KEGG; lel:LELG_04676; -.
DR   VEuPathDB; FungiDB:LELG_04676; -.
DR   eggNOG; ENOG502R9PE; Eukaryota.
DR   HOGENOM; CLU_040939_0_0_1; -.
DR   InParanoid; A5E4Y7; -.
DR   OMA; TRLTFNV; -.
DR   OrthoDB; 1283058at2759; -.
DR   Proteomes; UP000001996; Unassembled WGS sequence.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR013719; DUF1747.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR040770; Rtt106_PH.
DR   Pfam; PF18469; PH_18; 1.
DR   Pfam; PF08512; Rtt106; 1.
DR   SMART; SM01287; Rtt106; 1.
PE   3: Inferred from homology;
KW   Chaperone; Chromosome; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..492
FT                   /note="Histone chaperone RTT106"
FT                   /id="PRO_0000320494"
FT   REGION          392..492
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        412..470
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        471..492
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   492 AA;  55008 MW;  A0ADBD0BC71818CA CRC64;
     MTDWIGQFPK ELQDRIQAVV SRDASSQQVF IDVINFIEKE ESNKRRKLAS GLGLAEDSND
     AVGSSLDELS PSPTIHPDTI IFEIPQVSFM SPVRKRMNLT FHLIEQNGQG LPVLSIVNPA
     NNSPDISYIN LQNAVKLCLI LPILGNSTNP LKKGVVTLCC WMHDLYYTDV NVSKDPLILQ
     LNLDAIKKLM IKSEKLPADI ENQFDLTNYR NSVILNPIQE RIIDYFTRQF KLCGVNLVSY
     LPSDTIVKNS FIVNQDTAVA LSTSGNDSTK PAMVMVECHK GARDGNLILL EQNEHNPAYI
     LFAFRKPTLV YAISRVLSAS YTSVTKHTFS LTIIVLNEKD EERSIEFSII DQAYFQLIDD
     FIRSHGISDD SFNEDNKEKV VDSKANVVRA AVNGMLGTTT PATTNSRANG DGGDDDDDEE
     EDGDFEAGND DDDSDVAEEY DSAAESVEGE GEEEEEEEEE KEEDVEEEDE NNTGKERTKH
     RNGDVFTRSK EE