ID   RT106_NEOFI             Reviewed;         459 AA.
AC   A1DM87;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Histone chaperone rtt106;
GN   Name=rtt106; ORFNames=NFIA_052530;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS   / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC   / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Histones H3 and H4 chaperone involved in the nucleosome
CC       formation and heterochromatin silencing. Required for the deposition of
CC       H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role
CC       in the transcriptional regulation of the cell-cycle dependent histone
CC       genes by creating a repressive structure at the core histone gene
CC       promoter (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with histones H3 and H4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RTT106 family. {ECO:0000305}.
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DR   EMBL; DS027698; EAW15908.1; -; Genomic_DNA.
DR   RefSeq; XP_001257805.1; XM_001257804.1.
DR   AlphaFoldDB; A1DM87; -.
DR   SMR; A1DM87; -.
DR   STRING; 36630.CADNFIAP00004774; -.
DR   EnsemblFungi; EAW15908; EAW15908; NFIA_052530.
DR   GeneID; 4584320; -.
DR   KEGG; nfi:NFIA_052530; -.
DR   VEuPathDB; FungiDB:NFIA_052530; -.
DR   eggNOG; ENOG502R9PE; Eukaryota.
DR   HOGENOM; CLU_033828_0_0_1; -.
DR   OMA; AMPEAHR; -.
DR   OrthoDB; 1283058at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR013719; DUF1747.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   Pfam; PF08512; Rtt106; 1.
DR   SMART; SM01287; Rtt106; 1.
PE   3: Inferred from homology;
KW   Chaperone; Chromosome; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..459
FT                   /note="Histone chaperone rtt106"
FT                   /id="PRO_0000320496"
FT   REGION          64..96
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          370..459
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        398..413
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        420..443
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   459 AA;  50378 MW;  884659780FBD7D10 CRC64;
     MSFATINRSA TKALSASIPA IEDAFAAEPS LKKRVYDAIE STPQHVPLFE DIAKYTSSLL
     ARHANPPTQP VEADEGPAAK KRKLQNGNVA GDTQSSGDVK AEAPLQFYMQ DVSFAIPQRK
     KLTLEVTAGR GYLRARNQTS KEVEFGVPMD RIRHVLCLPV PEKSQRQFNF CIIPQYSDGI
     NPPPEGEQVF ESMVWTVSDG PAKAAFSGNG QQVGTGDGET AEALVRRVLN ENLSHTKVVR
     PDERQFVSAM PEAHRKAEKA YHVKAFRGSK EGYLFFLSTG IFFGFKKPLI FFAFENIESV
     SYTSVLQRTF NLNIAVRPHN GDENETQEFE LSMIDQADYA GIDAYIKKHG LQDASLAEAR
     RAKRYNINGA KAEEDAAGTA SDNAAEESEL QKAQRELEDQ EDEDEEDYDP GSDGESDGSG
     SSSEEGEDGD EEGDEDDEGQ DLVAAELGSE AEDVAEDEL