ID   RT106_PICGU             Reviewed;         443 AA.
AC   A5DEE9;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Histone chaperone RTT106;
GN   Name=RTT106; ORFNames=PGUG_01650;
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Histones H3 and H4 chaperone involved in the nucleosome
CC       formation and heterochromatin silencing. Required for the deposition of
CC       H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role
CC       in the transcriptional regulation of the cell-cycle dependent histone
CC       genes by creating a repressive structure at the core histone gene
CC       promoter (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with histones H3 and H4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RTT106 family. {ECO:0000305}.
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DR   EMBL; CH408156; EDK37552.2; -; Genomic_DNA.
DR   RefSeq; XP_001485979.1; XM_001485929.1.
DR   AlphaFoldDB; A5DEE9; -.
DR   SMR; A5DEE9; -.
DR   STRING; 4929.XP_001485979.1; -.
DR   EnsemblFungi; EDK37552; EDK37552; PGUG_01650.
DR   GeneID; 5127799; -.
DR   KEGG; pgu:PGUG_01650; -.
DR   VEuPathDB; FungiDB:PGUG_01650; -.
DR   eggNOG; ENOG502R9PE; Eukaryota.
DR   HOGENOM; CLU_040939_0_0_1; -.
DR   InParanoid; A5DEE9; -.
DR   OMA; TRLTFNV; -.
DR   OrthoDB; 1283058at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR013719; DUF1747.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR040770; Rtt106_PH.
DR   Pfam; PF18469; PH_18; 1.
DR   Pfam; PF08512; Rtt106; 1.
DR   SMART; SM01287; Rtt106; 1.
PE   3: Inferred from homology;
KW   Chaperone; Chromosome; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..443
FT                   /note="Histone chaperone RTT106"
FT                   /id="PRO_0000320499"
FT   REGION          38..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          358..443
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        358..375
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        376..393
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        402..443
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   443 AA;  48665 MW;  1C77D4368333F59B CRC64;
     MQWLHTLPPP LQDEVAALIS AVPQAAPTLD KLFEYASNSP QKQKIPDPPR KKRQQTSAPP
     QLPPPLTQAD IIFHLSNISC QSPFRKRLGF AFHLALGPQG PVPALSLVNN QLQPEFSLMN
     LGQDIVFCSL LPILGNSTVS SKKDTVLLLV WLAHGDPIVC QLNFDAVKKQ LVAEGKVPAS
     AESELDSESE EDDAEGIRPI NEALVDFLVR QFQLCGIRLL NYLPFSTGSK NKLTLNKDTA
     LALSTNGTSV NDVVIVQAYR GSKDGALVLL GGTQDQPGTI IFGFRKPILL FRANSVKRIS
     YSNITRLTFN VSVTVHNDTR PDGEETIEFS MLDQAYFQIL DDFVKRQGIN DDSFNEALRE
     KQKADPNVKA ETDAEDAEAP DSDDEEEDGT YQAGVESDSD NEKKEEDGEE NSEDEDSEDG
     EESEDSEDGE LSEDGESDDL SLS