ID   RT106_YARLI             Reviewed;         399 AA.
AC   Q6CHJ8;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Histone chaperone RTT106;
GN   Name=RTT106; OrderedLocusNames=YALI0A08107g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Histones H3 and H4 chaperone involved in the nucleosome
CC       formation and heterochromatin silencing. Required for the deposition of
CC       H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role
CC       in the transcriptional regulation of the cell-cycle dependent histone
CC       genes by creating a repressive structure at the core histone gene
CC       promoter (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with histones H3 and H4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RTT106 family. {ECO:0000305}.
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DR   EMBL; CR382127; CAG83789.1; -; Genomic_DNA.
DR   RefSeq; XP_499863.1; XM_499863.1.
DR   AlphaFoldDB; Q6CHJ8; -.
DR   SMR; Q6CHJ8; -.
DR   STRING; 4952.CAG83789; -.
DR   PRIDE; Q6CHJ8; -.
DR   EnsemblFungi; CAG83789; CAG83789; YALI0_A08107g.
DR   GeneID; 2905872; -.
DR   KEGG; yli:YALI0A08107g; -.
DR   VEuPathDB; FungiDB:YALI0_A08107g; -.
DR   HOGENOM; CLU_040939_1_0_1; -.
DR   InParanoid; Q6CHJ8; -.
DR   Proteomes; UP000001300; Chromosome A.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0031491; F:nucleosome binding; IBA:GO_Central.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR013719; DUF1747.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   Pfam; PF08512; Rtt106; 1.
DR   SMART; SM01287; Rtt106; 1.
PE   3: Inferred from homology;
KW   Chaperone; Chromosome; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..399
FT                   /note="Histone chaperone RTT106"
FT                   /id="PRO_0000320501"
FT   REGION          331..399
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        339..399
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   399 AA;  44335 MW;  9D0CDD8F9C08E745 CRC64;
     MYQPPRPFEL PSDLAAGITS LYRENADAKV IIDSLVKLAY DSGKEQSELV HKKAKVDGPP
     ATLSESIVSK LKIFLGINQV SVVLPIRKKL NVFIGADPRG KTWVWVSSKE DGSVDDMYPA
     TDTADFRCVA CLPVPDRSGT PLFNIVFVPG GAAQEVTTPP QPLVFSVPEE PAKKAFDGSL
     FLQGKDKNQF MYKDLILLGC QGISLPISVP DTEIFGEKFH VLAHKGAREG YLFFMQNEVI
     FGFKKPLLCM NTEDIESISF STITRLTFNI NIVLKSAPDV AMEFSLIDQS HYGEIAGFME
     RIAVKNESFD DKLKAKTFMK NQQPDNILAV AQNEAENEVP VAYDDEDEED DENYTGESSA
     SDGDADESDE EEAEEMEEQE REYDEELGDD EVEHDEDLG