RT10_CAEEL
ID RT10_CAEEL Reviewed; 156 AA.
AC Q9XWV5;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Probable 28S ribosomal protein S10, mitochondrial;
DE Short=MRP-S10;
DE Short=S10mt;
GN Name=mrps-10; ORFNames=Y37D8A.18;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=22511947; DOI=10.1371/journal.pone.0034507;
RA Billing O., Natarajan B., Mohammed A., Naredi P., Kao G.;
RT "A directed RNAi screen based on larval growth arrest reveals new modifiers
RT of C. elegans insulin signaling.";
RL PLoS ONE 7:E34507-E34507(2012).
CC -!- FUNCTION: Ribosomal protein required for normal mitochondrial function
CC and normal larval development. Thought to have a role in insulin/IGF
CC signaling. {ECO:0000269|PubMed:22511947}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC -!- DISRUPTION PHENOTYPE: Induction of dauer formation and larval arrest.
CC Reduced insulin/IGF signaling. {ECO:0000269|PubMed:22511947}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS10 family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL032626; CAA21535.1; -; Genomic_DNA.
DR PIR; T26634; T26634.
DR RefSeq; NP_499685.1; NM_067284.4.
DR AlphaFoldDB; Q9XWV5; -.
DR SMR; Q9XWV5; -.
DR BioGRID; 54251; 1.
DR STRING; 6239.Y37D8A.18; -.
DR EPD; Q9XWV5; -.
DR PaxDb; Q9XWV5; -.
DR PeptideAtlas; Q9XWV5; -.
DR EnsemblMetazoa; Y37D8A.18.1; Y37D8A.18.1; WBGene00012556.
DR GeneID; 189618; -.
DR KEGG; cel:CELE_Y37D8A.18; -.
DR UCSC; Y37D8A.18; c. elegans.
DR CTD; 189618; -.
DR WormBase; Y37D8A.18; CE20222; WBGene00012556; mrps-10.
DR eggNOG; KOG3321; Eukaryota.
DR GeneTree; ENSGT00390000009045; -.
DR HOGENOM; CLU_099082_1_0_1; -.
DR InParanoid; Q9XWV5; -.
DR OMA; IRWVQPA; -.
DR OrthoDB; 1528895at2759; -.
DR PhylomeDB; Q9XWV5; -.
DR Reactome; R-CEL-5389840; Mitochondrial translation elongation.
DR Reactome; R-CEL-5419276; Mitochondrial translation termination.
DR PRO; PR:Q9XWV5; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00012556; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0005763; C:mitochondrial small ribosomal subunit; IEA:InterPro.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR Gene3D; 3.30.70.600; -; 1.
DR InterPro; IPR040055; MRPS10.
DR InterPro; IPR027486; Ribosomal_S10_dom.
DR InterPro; IPR036838; Ribosomal_S10_dom_sf.
DR PANTHER; PTHR13334; PTHR13334; 1.
DR Pfam; PF00338; Ribosomal_S10; 1.
DR SMART; SM01403; Ribosomal_S10; 1.
DR SUPFAM; SSF54999; SSF54999; 1.
PE 3: Inferred from homology;
KW Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..156
FT /note="Probable 28S ribosomal protein S10, mitochondrial"
FT /id="PRO_0000146681"
SQ SEQUENCE 156 AA; 17858 MW; 471C3DE83275A131 CRC64;
MLKLASSLRT GLISRSIRTL APTVNPAEQQ QVQAVLPDKL YSSVEIEYRG HDKAVLKSYT
SFLQQVCQHL EIPQGRLEVL PYIRWVQPAL RSKFVHKKYK LHYETRTHIS KLEILNVTGS
TASTFLEYIQ RNIPEGVGMR VGFTELQPLP LTIQKN
