RT10_DROME
ID RT10_DROME Reviewed; 173 AA.
AC Q9VFB2; A8JR11; Q8IH25; Q8INE7; Q8SYL8;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=28S ribosomal protein S10, mitochondrial;
DE Short=MRP-S10;
DE Short=S10mt;
GN Name=mRpS10; ORFNames=CG4247;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A AND B).
RC STRAIN=Berkeley; TISSUE=Embryo, and Ovary;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- SUBUNIT: Component of the mitochondrial ribosome small subunit (28S)
CC which comprises a 12S rRNA and about 30 distinct proteins.
CC {ECO:0000250|UniProtKB:P82664}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P82664}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=B;
CC IsoId=Q9VFB2-1; Sequence=Displayed;
CC Name=A; Synonyms=C;
CC IsoId=Q9VFB2-2; Sequence=VSP_013575;
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS10 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN71219.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE014297; AAF55148.2; -; Genomic_DNA.
DR EMBL; AE014297; AAN13636.2; -; Genomic_DNA.
DR EMBL; AY071464; AAL49086.1; -; mRNA.
DR EMBL; BT001464; AAN71219.1; ALT_INIT; mRNA.
DR RefSeq; NP_524355.2; NM_079631.4. [Q9VFB2-1]
DR RefSeq; NP_731985.2; NM_169624.3. [Q9VFB2-2]
DR AlphaFoldDB; Q9VFB2; -.
DR SMR; Q9VFB2; -.
DR IntAct; Q9VFB2; 1.
DR STRING; 7227.FBpp0082513; -.
DR PaxDb; Q9VFB2; -.
DR PRIDE; Q9VFB2; -.
DR DNASU; 41838; -.
DR EnsemblMetazoa; FBtr0083053; FBpp0082512; FBgn0038307. [Q9VFB2-2]
DR EnsemblMetazoa; FBtr0083054; FBpp0082513; FBgn0038307. [Q9VFB2-1]
DR GeneID; 41838; -.
DR KEGG; dme:Dmel_CG4247; -.
DR UCSC; CG4247-RC; d. melanogaster.
DR CTD; 55173; -.
DR FlyBase; FBgn0038307; mRpS10.
DR VEuPathDB; VectorBase:FBgn0038307; -.
DR eggNOG; KOG3321; Eukaryota.
DR GeneTree; ENSGT00390000009045; -.
DR InParanoid; Q9VFB2; -.
DR OMA; IRWVQPA; -.
DR PhylomeDB; Q9VFB2; -.
DR Reactome; R-DME-5389840; Mitochondrial translation elongation.
DR Reactome; R-DME-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 41838; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 41838; -.
DR PRO; PR:Q9VFB2; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0038307; Expressed in egg chamber and 38 other tissues.
DR ExpressionAtlas; Q9VFB2; baseline and differential.
DR Genevisible; Q9VFB2; DM.
DR GO; GO:0005763; C:mitochondrial small ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; ISS:FlyBase.
DR GO; GO:0032543; P:mitochondrial translation; TAS:FlyBase.
DR Gene3D; 3.30.70.600; -; 1.
DR InterPro; IPR040055; MRPS10.
DR InterPro; IPR027486; Ribosomal_S10_dom.
DR InterPro; IPR036838; Ribosomal_S10_dom_sf.
DR PANTHER; PTHR13334; PTHR13334; 1.
DR Pfam; PF00338; Ribosomal_S10; 1.
DR SMART; SM01403; Ribosomal_S10; 1.
DR SUPFAM; SSF54999; SSF54999; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Mitochondrion; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein.
FT CHAIN 1..173
FT /note="28S ribosomal protein S10, mitochondrial"
FT /id="PRO_0000146682"
FT VAR_SEQ 1..12
FT /note="MKMHMKHLDLYS -> ML (in isoform A)"
FT /evidence="ECO:0000303|PubMed:12537569"
FT /id="VSP_013575"
SQ SEQUENCE 173 AA; 20031 MW; AEDB01EB41DD3623 CRC64;
MKMHMKHLDL YSQAIKTLRW TQPMRALSTV NTSSGVQGNL SPAAPAPEPD KLYSKLEIEL
RGIDPAVLKS YTWFATTAAE HLGIEKGKCW SPRKAHHERM TLLKSVHIYK KHRVQYEVRT
HFRYMNFHKL TGSTLDTFLE YIERNLPEGV ALQASRTELQ EIPEHLRQPP EQV
