RT12_ARATH
ID RT12_ARATH Reviewed; 125 AA.
AC P92532; A7KNK5; F4IL88; Q8RUS9;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 04-MAY-2001, sequence version 2.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Ribosomal protein S12, mitochondrial;
GN Name=RPS12; OrderedLocusNames=AtMg00980 {ECO:0000312|Araport:ATMG00980};
GN and
GN OrderedLocusNames=At2g07675 {ECO:0000312|Araport:AT2G07675};
OS Arabidopsis thaliana (Mouse-ear cress).
OG Mitochondrion.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. C24;
RX PubMed=8988169; DOI=10.1038/ng0197-57;
RA Unseld M., Marienfeld J.R., Brandt P., Brennicke A.;
RT "The mitochondrial genome of Arabidopsis thaliana contains 57 genes in
RT 366,924 nucleotides.";
RL Nat. Genet. 15:57-61(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. C24, cv. Columbia, and cv. Landsberg erecta;
RX PubMed=21951689; DOI=10.1186/1741-7007-9-64;
RA Davila J.I., Arrieta-Montiel M.P., Wamboldt Y., Cao J., Hagmann J.,
RA Shedge V., Xu Y.Z., Weigel D., Mackenzie S.A.;
RT "Double-strand break repair processes drive evolution of the mitochondrial
RT genome in Arabidopsis.";
RL BMC Biol. 9:64-64(2011).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (AT2G07675).
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [4]
RP GENOME REANNOTATION (AT2G07675).
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 18-118, AND RNA EDITING.
RC STRAIN=cv. Columbia, and cv. Landsberg erecta; TISSUE=Rosette leaf;
RX PubMed=17565941; DOI=10.1534/genetics.107.073585;
RA Bentolila S., Elliott L.E., Hanson M.R.;
RT "Genetic architecture of mitochondrial editing in Arabidopsis thaliana.";
RL Genetics 178:1693-1708(2008).
RN [6]
RP RNA EDITING.
RX PubMed=10611383; DOI=10.1073/pnas.96.26.15324;
RA Giege P., Brennicke A.;
RT "RNA editing in Arabidopsis mitochondria effects 441 C to U changes in
RT ORFs.";
RL Proc. Natl. Acad. Sci. U.S.A. 96:15324-15329(1999).
CC -!- FUNCTION: Protein S12 is involved in the translation initiation step.
CC -!- SUBCELLULAR LOCATION: Mitochondrion.
CC -!- RNA EDITING: Modified_positions=35 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 49 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 66 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 74 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 90 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 95 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941};
CC -!- MISCELLANEOUS: A stretch of 270 kb of the mitochondrial genome is
CC duplicated within the centromere of chromosome 2 resulting in the
CC duplication of the gene. The expression of this duplicated gene
CC (At2g07675) is not demonstrated. It is also probably not RNA edited and
CC therefore differs in all the positions known to be edited.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS12 family.
CC {ECO:0000305}.
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DR EMBL; Y08501; CAA69838.3; ALT_SEQ; Genomic_DNA.
DR EMBL; JF729200; AEK01266.1; ALT_SEQ; Genomic_DNA.
DR EMBL; JF729201; AEK01295.1; ALT_SEQ; Genomic_DNA.
DR EMBL; JF729202; AEK01323.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC007143; AAM15421.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC007730; AAM15516.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC06070.1; ALT_SEQ; Genomic_DNA.
DR EMBL; EF488948; ABS50660.1; -; mRNA.
DR EMBL; EF488949; ABS50661.1; -; mRNA.
DR RefSeq; NP_085552.2; NC_001284.2.
DR RefSeq; NP_178773.1; NM_126732.2.
DR PDB; 6XYW; EM; 3.86 A; Bk=1-125.
DR PDBsum; 6XYW; -.
DR AlphaFoldDB; P92532; -.
DR SMR; P92532; -.
DR BioGRID; 566539; 1.
DR IntAct; P92532; 1.
DR STRING; 3702.AT2G07675.1; -.
DR PaxDb; P92532; -.
DR PeptideAtlas; P92532; -.
DR PRIDE; P92532; -.
DR GeneID; 815348; -.
DR KEGG; ath:AT2G07675; -.
DR Araport; AT2G07675; -.
DR Araport; ATMG00980; -.
DR eggNOG; KOG1750; Eukaryota.
DR HOGENOM; CLU_104295_1_2_1; -.
DR InParanoid; P92532; -.
DR OrthoDB; 1542634at2759; -.
DR PhylomeDB; P92532; -.
DR PRO; PR:P92532; -.
DR Proteomes; UP000006548; Chromosome 2.
DR Proteomes; UP000006548; Mitochondrion (cv. C24).
DR ExpressionAtlas; P92532; baseline and differential.
DR Genevisible; P92532; AT.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005840; C:ribosome; IBA:GO_Central.
DR GO; GO:0015935; C:small ribosomal subunit; IEA:InterPro.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IBA:GO_Central.
DR CDD; cd03368; Ribosomal_S12; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR HAMAP; MF_00403_B; Ribosomal_S12_B; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR006032; Ribosomal_S12/S23.
DR InterPro; IPR005679; Ribosomal_S12_bac.
DR PANTHER; PTHR11652; PTHR11652; 1.
DR Pfam; PF00164; Ribosom_S12_S23; 1.
DR PIRSF; PIRSF002133; Ribosomal_S12/S23; 1.
DR PRINTS; PR01034; RIBOSOMALS12.
DR SUPFAM; SSF50249; SSF50249; 1.
DR TIGRFAMs; TIGR00981; rpsL_bact; 1.
DR PROSITE; PS00055; RIBOSOMAL_S12; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Mitochondrion; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein; RNA editing.
FT CHAIN 1..125
FT /note="Ribosomal protein S12, mitochondrial"
FT /id="PRO_0000146433"
SQ SEQUENCE 125 AA; 14248 MW; 0C0593BCFA098B06 CRC64;
MPTFNQLIRH GREEKRRTDR TRALDKCPQK TGVCLRVSTR TPKKPNSALR KIAKVRLSNR
HDIFAYIPGE GHNLQEHSTV LIRGGRVKDL PGVKFHCIRG VKDLMGIPGR RRGRSKYGAE
KPKSI
