ID   BCN02_PAEPO             Reviewed;          39 AA.
AC   P86393;
DT   19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT   19-JAN-2010, sequence version 1.
DT   25-MAY-2022, entry version 23.
DE   RecName: Full=Bacteriocin SRCAM 602 {ECO:0000303|PubMed:15690798};
OS   Paenibacillus polymyxa (Bacillus polymyxa).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX   NCBI_TaxID=1406;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR
RP   LOCATION, AND MASS SPECTROMETRY.
RC   STRAIN=NRRL B-30509 {ECO:0000269|PubMed:15690798};
RX   PubMed=15690798; DOI=10.4315/0362-028x-68.1.11;
RA   Svetoch E.A., Stern N.J., Eruslanov B.V., Kovalev Y.N., Volodina L.I.,
RA   Perelygin V.V., Mitsevich E.V., Mitsevich I.P., Pokhilenko V.D.,
RA   Borzenkov V.N., Levchuk V.P., Svetoch O.E., Kudriavtseva T.Y.;
RT   "Isolation of Bacillus circulans and Paenibacillus polymyxa strains
RT   inhibitory to Campylobacter jejuni and characterization of associated
RT   bacteriocins.";
RL   J. Food Prot. 68:11-17(2005).
CC   -!- FUNCTION: Bacteriocin with antibacterial activity against C.jejuni.
CC       {ECO:0000269|PubMed:15690798}.
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       pH dependence:
CC         Stable from pH 3.0-9.0, inactivated at pH 10.0.
CC         {ECO:0000269|PubMed:15690798};
CC       Temperature dependence:
CC         Thermostable, activity is retained after incubation at 100 degrees
CC         Celsius for 15 minutes. {ECO:0000269|PubMed:15690798};
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15690798}.
CC   -!- MASS SPECTROMETRY: Mass=3864; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:15690798};
CC   -!- MISCELLANEOUS: Antimicrobial activity is lost upon treatment with beta-
CC       chymotrypsin, proteinase K and papain, but not when treated with
CC       lysozyme or lipase. {ECO:0000269|PubMed:15690798}.
CC   -!- SIMILARITY: Belongs to the bacteriocin class IIA/YGNGV family.
CC       {ECO:0000255}.
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DR   AlphaFoldDB; P86393; -.
DR   SMR; P86393; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.130; -; 1.
DR   InterPro; IPR002633; Bacteriocin_IIa.
DR   InterPro; IPR023388; Bacteriocin_IIa_dom_sf.
DR   Pfam; PF01721; Bacteriocin_II; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Bacteriocin; Direct protein sequencing;
KW   Secreted.
FT   CHAIN           1..39
FT                   /note="Bacteriocin SRCAM 602"
FT                   /id="PRO_0000390699"
SQ   SEQUENCE   39 AA;  4630 MW;  7F641BD4004E27F2 CRC64;
     ATYYGNGLYC NKQKHYTWVD WNKASREIGK ITVNGWVQH