RT15_BOVIN
ID RT15_BOVIN Reviewed; 256 AA.
AC P82913; E1BBB4;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2017, sequence version 3.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=28S ribosomal protein S15, mitochondrial;
DE Short=MRP-S15;
DE Short=S15mt;
DE Flags: Precursor;
GN Name=MRPS15; Synonyms=RPMS15;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford;
RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT "A whole-genome assembly of the domestic cow, Bos taurus.";
RL Genome Biol. 10:R42.01-R42.10(2009).
RN [2]
RP PROTEIN SEQUENCE OF 53-59, SUBCELLULAR LOCATION, AND SUBUNIT.
RX PubMed=11402041; DOI=10.1074/jbc.m103236200;
RA Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A.,
RA Watanabe K.;
RT "Proteomic analysis of the mammalian mitochondrial ribosome. Identification
RT of protein components in the 28S small subunit.";
RL J. Biol. Chem. 276:33181-33195(2001).
RN [3]
RP PROTEIN SEQUENCE OF 74-98; 152-161; 176-197 AND 208-226, SUBCELLULAR
RP LOCATION, AND SUBUNIT.
RC TISSUE=Liver;
RX PubMed=11279123; DOI=10.1074/jbc.m100727200;
RA Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.;
RT "The small subunit of the mammalian mitochondrial ribosome: identification
RT of the full complement of ribosomal proteins present.";
RL J. Biol. Chem. 276:19363-19374(2001).
RN [4] {ECO:0007744|PDB:3JD5}
RP STRUCTURE BY ELECTRON MICROSCOPY (7.00 ANGSTROMS), SUBCELLULAR LOCATION,
RP AND SUBUNIT.
RX PubMed=24799711; DOI=10.1073/pnas.1401657111;
RA Kaushal P.S., Sharma M.R., Booth T.M., Haque E.M., Tung C.S.,
RA Sanbonmatsu K.Y., Spremulli L.L., Agrawal R.K.;
RT "Cryo-EM structure of the small subunit of the mammalian mitochondrial
RT ribosome.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:7284-7289(2014).
CC -!- SUBUNIT: Component of the mitochondrial ribosome small subunit (28S)
CC which comprises a 12S rRNA and about 30 distinct proteins
CC (PubMed:11279123, PubMed:11402041, PubMed:24799711). Interacts with
CC METTL17 (By similarity). {ECO:0000250|UniProtKB:Q9DC71,
CC ECO:0000269|PubMed:11279123, ECO:0000269|PubMed:11402041,
CC ECO:0000269|PubMed:24799711}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11279123,
CC ECO:0000269|PubMed:11402041, ECO:0000269|PubMed:24799711}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS15 family.
CC {ECO:0000305}.
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DR EMBL; DAAA02009202; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PDB; 3JD5; EM; 7.00 A; O=1-256.
DR PDB; 6NEQ; EM; 3.32 A; O=1-256.
DR PDB; 6NF8; EM; 3.48 A; O=1-256.
DR PDBsum; 3JD5; -.
DR PDBsum; 6NEQ; -.
DR PDBsum; 6NF8; -.
DR AlphaFoldDB; P82913; -.
DR SMR; P82913; -.
DR CORUM; P82913; -.
DR IntAct; P82913; 2.
DR STRING; 9913.ENSBTAP00000033158; -.
DR PRIDE; P82913; -.
DR eggNOG; KOG2815; Eukaryota.
DR TreeFam; TF319038; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
DR GO; GO:0005763; C:mitochondrial small ribosomal subunit; IDA:UniProtKB.
DR GO; GO:0003735; F:structural constituent of ribosome; HDA:UniProtKB.
DR GO; GO:0032543; P:mitochondrial translation; HDA:UniProtKB.
DR CDD; cd00353; Ribosomal_S15p_S13e; 1.
DR HAMAP; MF_01343_B; Ribosomal_S15_B; 1.
DR InterPro; IPR000589; Ribosomal_S15.
DR InterPro; IPR005290; Ribosomal_S15_bac-type.
DR InterPro; IPR009068; S15_NS1_RNA-bd.
DR Pfam; PF00312; Ribosomal_S15; 1.
DR SMART; SM01387; Ribosomal_S15; 1.
DR SUPFAM; SSF47060; SSF47060; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Mitochondrion; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein; Transit peptide.
FT TRANSIT 1..53
FT /note="Mitochondrion"
FT /evidence="ECO:0000269|PubMed:11402041"
FT CHAIN 54..256
FT /note="28S ribosomal protein S15, mitochondrial"
FT /id="PRO_0000115659"
FT REGION 226..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 73..75
FT /evidence="ECO:0007829|PDB:6NEQ"
FT STRAND 76..80
FT /evidence="ECO:0007829|PDB:6NEQ"
FT STRAND 82..84
FT /evidence="ECO:0007829|PDB:6NF8"
FT HELIX 86..91
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 94..96
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 99..111
FT /evidence="ECO:0007829|PDB:6NEQ"
FT TURN 112..114
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 124..144
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 149..170
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 174..183
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 200..234
FT /evidence="ECO:0007829|PDB:6NEQ"
SQ SEQUENCE 256 AA; 29190 MW; 63D6EB64776E2740 CRC64;
MLRAAWRALS SIRTQAVTQP PVLGLPGGGC AKLLSVQRDL PSSLILQAAR GYATQKPVQQ
SQEDDPPPSM LLKDYQNVPG IEKVDDVVKR LISLEMANKK EMLKIKKEQL MSKVVENPKD
TSSLEAQIVA LTVKIRSYEE HMQKHQKDKA HKRYLLMSID KRQKMLKNLR KTNYPVFEKT
CKELGIEYTF PPPYHRKIHR RLATKKALCI RVFQEVQKLK KQKRALKTAA AAAQKQGQRN
PESPSEARSE AIKETQ
