RT15_MOUSE
ID RT15_MOUSE Reviewed; 258 AA.
AC Q9DC71; Q7TMG9; Q8C7F1; Q9CVE0; Q9CWX1;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 04-MAY-2001, sequence version 2.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=28S ribosomal protein S15, mitochondrial;
DE Short=MRP-S15;
DE Short=S15mt;
DE Flags: Precursor;
GN Name=Mrps15; Synonyms=Rpms15;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11402041; DOI=10.1074/jbc.m103236200;
RA Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A.,
RA Watanabe K.;
RT "Proteomic analysis of the mammalian mitochondrial ribosome. Identification
RT of protein components in the 28S small subunit.";
RL J. Biol. Chem. 276:33181-33195(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryonic stem cell, Heart, Liver, and Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II, and FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Kidney, and Liver;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP INTERACTION WITH METTL17.
RX PubMed=31487196; DOI=10.1096/fj.201901331r;
RA Shi Z., Xu S., Xing S., Yao K., Zhang L., Xue L., Zhou P., Wang M., Yan G.,
RA Yang P., Liu J., Hu Z., Lan F.;
RT "Mettl17, a regulator of mitochondrial ribosomal RNA modifications, is
RT required for the translation of mitochondrial coding genes.";
RL FASEB J. 33:13040-13050(2019).
CC -!- SUBUNIT: Component of the mitochondrial ribosome small subunit (28S)
CC which comprises a 12S rRNA and about 30 distinct proteins (By
CC similarity). Interacts with METTL17 (PubMed:31487196).
CC {ECO:0000250|UniProtKB:P82913, ECO:0000269|PubMed:31487196}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P82913}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS15 family.
CC {ECO:0000305}.
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DR EMBL; AB049947; BAB41000.1; -; mRNA.
DR EMBL; AK003126; BAB22586.1; -; mRNA.
DR EMBL; AK010330; BAB26857.1; -; mRNA.
DR EMBL; AK008623; BAB25785.1; -; mRNA.
DR EMBL; AK050396; BAC34235.1; -; mRNA.
DR EMBL; BC029193; AAH29193.1; -; mRNA.
DR EMBL; BC055861; AAH55861.1; -; mRNA.
DR CCDS; CCDS18641.1; -.
DR RefSeq; NP_079820.2; NM_025544.2.
DR AlphaFoldDB; Q9DC71; -.
DR SMR; Q9DC71; -.
DR BioGRID; 211451; 13.
DR ComplexPortal; CPX-5301; 28S mitochondrial small ribosomal subunit.
DR IntAct; Q9DC71; 2.
DR MINT; Q9DC71; -.
DR STRING; 10090.ENSMUSP00000030675; -.
DR iPTMnet; Q9DC71; -.
DR PhosphoSitePlus; Q9DC71; -.
DR EPD; Q9DC71; -.
DR jPOST; Q9DC71; -.
DR MaxQB; Q9DC71; -.
DR PaxDb; Q9DC71; -.
DR PeptideAtlas; Q9DC71; -.
DR PRIDE; Q9DC71; -.
DR ProteomicsDB; 261001; -.
DR Antibodypedia; 31697; 189 antibodies from 27 providers.
DR Ensembl; ENSMUST00000030675; ENSMUSP00000030675; ENSMUSG00000028861.
DR GeneID; 66407; -.
DR KEGG; mmu:66407; -.
DR UCSC; uc008usf.1; mouse.
DR CTD; 64960; -.
DR MGI; MGI:1913657; Mrps15.
DR VEuPathDB; HostDB:ENSMUSG00000028861; -.
DR eggNOG; KOG2815; Eukaryota.
DR GeneTree; ENSGT00390000001737; -.
DR HOGENOM; CLU_094627_0_0_1; -.
DR InParanoid; Q9DC71; -.
DR OMA; KRHLLMS; -.
DR OrthoDB; 1539741at2759; -.
DR PhylomeDB; Q9DC71; -.
DR TreeFam; TF319038; -.
DR Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 66407; 25 hits in 73 CRISPR screens.
DR ChiTaRS; Mrps15; mouse.
DR PRO; PR:Q9DC71; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9DC71; protein.
DR Bgee; ENSMUSG00000028861; Expressed in facial nucleus and 261 other tissues.
DR Genevisible; Q9DC71; MM.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR GO; GO:0005761; C:mitochondrial ribosome; IDA:MGI.
DR GO; GO:0005763; C:mitochondrial small ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0003735; F:structural constituent of ribosome; ISS:UniProtKB.
DR GO; GO:0032543; P:mitochondrial translation; ISS:UniProtKB.
DR CDD; cd00353; Ribosomal_S15p_S13e; 1.
DR HAMAP; MF_01343_B; Ribosomal_S15_B; 1.
DR InterPro; IPR000589; Ribosomal_S15.
DR InterPro; IPR005290; Ribosomal_S15_bac-type.
DR InterPro; IPR009068; S15_NS1_RNA-bd.
DR Pfam; PF00312; Ribosomal_S15; 1.
DR SMART; SM01387; Ribosomal_S15; 1.
DR SUPFAM; SSF47060; SSF47060; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW Transit peptide.
FT TRANSIT 1..57
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 58..258
FT /note="28S ribosomal protein S15, mitochondrial"
FT /id="PRO_0000030615"
FT REGION 229..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 139
FT /note="N -> D (in Ref. 2; BAC34235)"
FT /evidence="ECO:0000305"
FT CONFLICT 180
FT /note="E -> G (in Ref. 2; BAB26857)"
FT /evidence="ECO:0000305"
FT CONFLICT 241
FT /note="E -> G (in Ref. 1; BAB41000 and 2; BAB22586)"
FT /evidence="ECO:0000305"
FT CONFLICT 251
FT /note="V -> L (in Ref. 3; AAH55861)"
FT /evidence="ECO:0000305"
FT CONFLICT 257
FT /note="V -> M (in Ref. 2; BAB26857)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 258 AA; 29464 MW; 98FF04FA2EE78D96 CRC64;
MLRAAWRALS SVRAQAVTRA PVPALRGGSS ASLLSARCGL QPPSLLRAAR AYAAVQKPVQ
PKQDDEPPSS AFIKEYKDII PNIEKVDDVV KRILSLEMAS RKEKLKIKQE QLMNKIVENP
EDSRTLEAQI IALTVRIRNY EEHMQKHRKD KAHKRHLLMS IDRRKKLLKI LRQTNYDVFE
KTCKELGVEY TLPPLHFQKV HRRFLAKKAL CIRVYQEVQK LKKQKRALKA AAAAAKKEKN
EGVPENPSNA VPEKTQVN
