BCN92_DROME
ID BCN92_DROME Reviewed; 92 AA.
AC O46098; Q9U5X3;
DT 28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Protein bcn92 {ECO:0000312|FlyBase:FBgn0013432};
GN Name=bcn92 {ECO:0000312|FlyBase:FBgn0013432};
GN Synonyms=Isd11 {ECO:0000303|PubMed:29491838,
GN ECO:0000312|FlyBase:FBgn0013432};
GN ORFNames=CG3717 {ECO:0000312|FlyBase:FBgn0013432};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|EMBL:AAL49164.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Oregon-R;
RX PubMed=10731137; DOI=10.1126/science.287.5461.2220;
RA Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D., Barrell B.G.,
RA Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Borkova D., Minana B., Kafatos F.C.,
RA Louis C., Siden-Kiamos I., Bolshakov S., Papagiannakis G., Spanos L.,
RA Cox S., Madueno E., de Pablos B., Modolell J., Peter A., Schoettler P.,
RA Werner M., Mourkioti F., Beinert N., Dowe G., Schaefer U., Jaeckle H.,
RA Bucheton A., Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S.,
RA McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C.,
RA Glover D.M.;
RT "From sequence to chromosome: the tip of the X chromosome of D.
RT melanogaster.";
RL Science 287:2220-2222(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-67.
RX PubMed=7705632; DOI=10.1093/genetics/139.1.321;
RA Cirera S., Martin-Campos J.M., Segarra C., Aguade M.;
RT "Molecular characterization of the breakpoints of an inversion fixed
RT between Drosophila melanogaster and D. subobscura.";
RL Genetics 139:321-326(1995).
RN [6]
RP INTERACTION WITH NFS1; ISCU AND FH, AND SUBCELLULAR LOCATION.
RX PubMed=29491838; DOI=10.3389/fphys.2018.00050;
RA Marelja Z., Leimkuehler S., Missirlis F.;
RT "Iron Sulfur and Molybdenum Cofactor Enzymes Regulate the Drosophila Life
RT Cycle by Controlling Cell Metabolism.";
RL Front. Physiol. 9:50-50(2018).
CC -!- SUBUNIT: Interacts with Nfs1 (PubMed:29491838). Might form a complex
CC with Nfs1, IscU and fh (Probable). {ECO:0000269|PubMed:29491838,
CC ECO:0000305|PubMed:29491838}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:29491838}.
CC -!- SIMILARITY: Belongs to the complex I LYR family. {ECO:0000305}.
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DR EMBL; AE014298; AAF45733.1; -; Genomic_DNA.
DR EMBL; Z98269; CAB10976.1; -; Genomic_DNA.
DR EMBL; AY071542; AAL49164.1; -; mRNA.
DR EMBL; Z46608; CAB56152.1; -; Genomic_DNA.
DR PIR; T13609; T13609.
DR RefSeq; NP_477059.2; NM_057711.3.
DR AlphaFoldDB; O46098; -.
DR SMR; O46098; -.
DR BioGRID; 57727; 4.
DR STRING; 7227.FBpp0070415; -.
DR PaxDb; O46098; -.
DR PRIDE; O46098; -.
DR DNASU; 31186; -.
DR EnsemblMetazoa; FBtr0070431; FBpp0070415; FBgn0013432.
DR GeneID; 31186; -.
DR KEGG; dme:Dmel_CG3717; -.
DR UCSC; CG3717-RA; d. melanogaster.
DR CTD; 31186; -.
DR FlyBase; FBgn0013432; bcn92.
DR VEuPathDB; VectorBase:FBgn0013432; -.
DR eggNOG; KOG3801; Eukaryota.
DR GeneTree; ENSGT00940000170978; -.
DR HOGENOM; CLU_120076_3_1_1; -.
DR InParanoid; O46098; -.
DR OMA; AYNYRMY; -.
DR OrthoDB; 1561410at2759; -.
DR PhylomeDB; O46098; -.
DR Reactome; R-DME-1362409; Mitochondrial iron-sulfur cluster biogenesis.
DR BioGRID-ORCS; 31186; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 31186; -.
DR PRO; PR:O46098; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0013432; Expressed in head capsule and 22 other tissues.
DR ExpressionAtlas; O46098; baseline and differential.
DR Genevisible; O46098; DM.
DR GO; GO:1990221; C:L-cysteine desulfurase complex; IPI:FlyBase.
DR GO; GO:0005739; C:mitochondrion; IDA:FlyBase.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IDA:FlyBase.
DR CDD; cd20264; Complex1_LYR_LYRM4; 1.
DR InterPro; IPR008011; Complex1_LYR_dom.
DR InterPro; IPR045297; Complex1_LYR_LYRM4.
DR Pfam; PF05347; Complex1_LYR; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Mitochondrion; Reference proteome.
FT CHAIN 1..92
FT /note="Protein bcn92"
FT /id="PRO_0000174312"
FT COILED 48..68
FT /evidence="ECO:0000255"
SQ SEQUENCE 92 AA; 10962 MW; 95EBE6BE1B3AE820 CRC64;
MSTRRQAITL YRNLLRESEK LPSYNFRMYA ARKIRDTFRA NRSTRDFAEI DRQMAEGQQN
LELIRRQVII GHLYSADKLV IENKKTLKPS DD
