RT17_HUMAN
ID RT17_HUMAN Reviewed; 130 AA.
AC Q9Y2R5; Q86X15;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 181.
DE RecName: Full=28S ribosomal protein S17, mitochondrial;
DE Short=MRP-S17;
DE Short=S17mt;
DE AltName: Full=Mitochondrial small ribosomal subunit protein uS17m {ECO:0000303|PubMed:25838379};
DE Flags: Precursor;
GN Name=MRPS17; Synonyms=RPMS17; ORFNames=HSPC011;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Umbilical cord blood;
RX PubMed=9653160; DOI=10.1073/pnas.95.14.8175;
RA Mao M., Fu G., Wu J.-S., Zhang Q.-H., Zhou J., Kan L.-X., Huang Q.-H.,
RA He K.-L., Gu B.-W., Han Z.-G., Shen Y., Gu J., Yu Y.-P., Xu S.-H.,
RA Wang Y.-X., Chen S.-J., Chen Z.;
RT "Identification of genes expressed in human CD34(+) hematopoietic
RT stem/progenitor cells by expressed sequence tags and efficient full-length
RT cDNA cloning.";
RL Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11402041; DOI=10.1074/jbc.m103236200;
RA Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A.,
RA Watanabe K.;
RT "Proteomic analysis of the mammalian mitochondrial ribosome. Identification
RT of protein components in the 28S small subunit.";
RL J. Biol. Chem. 276:33181-33195(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=11279123; DOI=10.1074/jbc.m100727200;
RA Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.;
RT "The small subunit of the mammalian mitochondrial ribosome: identification
RT of the full complement of ribosomal proteins present.";
RL J. Biol. Chem. 276:19363-19374(2001).
RN [5] {ECO:0007744|PDB:3J9M}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS), SUBCELLULAR LOCATION,
RP AND SUBUNIT.
RX PubMed=25838379; DOI=10.1126/science.aaa1193;
RA Amunts A., Brown A., Toots J., Scheres S.H., Ramakrishnan V.;
RT "Ribosome. The structure of the human mitochondrial ribosome.";
RL Science 348:95-98(2015).
CC -!- SUBUNIT: Component of the mitochondrial small ribosomal subunit (mt-
CC SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small
CC (28S) and a large (39S) subunit. The 28S small subunit contains a 12S
CC ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large
CC subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial
CC valine transfer RNA (mt-tRNA(Val)), which plays an integral structural
CC role, and 52 different proteins. {ECO:0000269|PubMed:25838379}.
CC -!- INTERACTION:
CC Q9Y2R5; P28799: GRN; NbExp=3; IntAct=EBI-1046443, EBI-747754;
CC Q9Y2R5; O76024: WFS1; NbExp=3; IntAct=EBI-1046443, EBI-720609;
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS17 family.
CC {ECO:0000305}.
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DR EMBL; AF077035; AAD27768.1; -; mRNA.
DR EMBL; AB049950; BAB41003.1; -; mRNA.
DR EMBL; BC047445; AAH47445.2; -; mRNA.
DR EMBL; BC054031; AAH54031.1; -; mRNA.
DR CCDS; CCDS5520.1; -.
DR RefSeq; NP_057053.1; NM_015969.2.
DR PDB; 3J9M; EM; 3.50 A; AN=1-130.
DR PDB; 6NU2; EM; 3.90 A; AN=5-111.
DR PDB; 6NU3; EM; 4.40 A; AN=1-130.
DR PDB; 6RW4; EM; 2.97 A; N=1-130.
DR PDB; 6RW5; EM; 3.14 A; N=1-130.
DR PDB; 6VLZ; EM; 2.97 A; AN=1-130.
DR PDB; 6VMI; EM; 2.96 A; AN=1-130.
DR PDB; 6ZM5; EM; 2.89 A; AN=1-130.
DR PDB; 6ZM6; EM; 2.59 A; AN=1-130.
DR PDB; 6ZS9; EM; 4.00 A; AN=1-130.
DR PDB; 6ZSA; EM; 4.00 A; AN=1-130.
DR PDB; 6ZSB; EM; 4.50 A; AN=1-130.
DR PDB; 6ZSC; EM; 3.50 A; AN=1-130.
DR PDB; 6ZSD; EM; 3.70 A; AN=1-130.
DR PDB; 6ZSE; EM; 5.00 A; AN=1-130.
DR PDB; 6ZSG; EM; 4.00 A; AN=1-130.
DR PDB; 7A5F; EM; 4.40 A; N6=1-130.
DR PDB; 7A5G; EM; 4.33 A; N6=1-130.
DR PDB; 7A5I; EM; 3.70 A; N6=1-130.
DR PDB; 7A5K; EM; 3.70 A; N6=1-130.
DR PDB; 7L08; EM; 3.49 A; AN=1-130.
DR PDB; 7OG4; EM; 3.80 A; AN=1-130.
DR PDBsum; 3J9M; -.
DR PDBsum; 6NU2; -.
DR PDBsum; 6NU3; -.
DR PDBsum; 6RW4; -.
DR PDBsum; 6RW5; -.
DR PDBsum; 6VLZ; -.
DR PDBsum; 6VMI; -.
DR PDBsum; 6ZM5; -.
DR PDBsum; 6ZM6; -.
DR PDBsum; 6ZS9; -.
DR PDBsum; 6ZSA; -.
DR PDBsum; 6ZSB; -.
DR PDBsum; 6ZSC; -.
DR PDBsum; 6ZSD; -.
DR PDBsum; 6ZSE; -.
DR PDBsum; 6ZSG; -.
DR PDBsum; 7A5F; -.
DR PDBsum; 7A5G; -.
DR PDBsum; 7A5I; -.
DR PDBsum; 7A5K; -.
DR PDBsum; 7L08; -.
DR PDBsum; 7OG4; -.
DR AlphaFoldDB; Q9Y2R5; -.
DR SMR; Q9Y2R5; -.
DR BioGRID; 119506; 221.
DR ComplexPortal; CPX-5225; 28S mitochondrial small ribosomal subunit.
DR CORUM; Q9Y2R5; -.
DR IntAct; Q9Y2R5; 32.
DR MINT; Q9Y2R5; -.
DR STRING; 9606.ENSP00000285298; -.
DR iPTMnet; Q9Y2R5; -.
DR PhosphoSitePlus; Q9Y2R5; -.
DR BioMuta; MRPS17; -.
DR DMDM; 13633951; -.
DR EPD; Q9Y2R5; -.
DR jPOST; Q9Y2R5; -.
DR MassIVE; Q9Y2R5; -.
DR MaxQB; Q9Y2R5; -.
DR PaxDb; Q9Y2R5; -.
DR PeptideAtlas; Q9Y2R5; -.
DR PRIDE; Q9Y2R5; -.
DR ProteomicsDB; 85880; -.
DR TopDownProteomics; Q9Y2R5; -.
DR Antibodypedia; 66312; 63 antibodies from 19 providers.
DR DNASU; 51373; -.
DR Ensembl; ENST00000285298.9; ENSP00000285298.4; ENSG00000239789.6.
DR GeneID; 51373; -.
DR KEGG; hsa:51373; -.
DR MANE-Select; ENST00000285298.9; ENSP00000285298.4; NM_015969.3; NP_057053.1.
DR UCSC; uc003trd.4; human.
DR CTD; 51373; -.
DR DisGeNET; 51373; -.
DR GeneCards; MRPS17; -.
DR HGNC; HGNC:14047; MRPS17.
DR HPA; ENSG00000239789; Low tissue specificity.
DR MIM; 611980; gene.
DR neXtProt; NX_Q9Y2R5; -.
DR OpenTargets; ENSG00000239789; -.
DR PharmGKB; PA31002; -.
DR VEuPathDB; HostDB:ENSG00000239789; -.
DR eggNOG; KOG3447; Eukaryota.
DR GeneTree; ENSGT00530000064130; -.
DR InParanoid; Q9Y2R5; -.
DR OrthoDB; 1515865at2759; -.
DR PhylomeDB; Q9Y2R5; -.
DR TreeFam; TF326484; -.
DR PathwayCommons; Q9Y2R5; -.
DR Reactome; R-HSA-5368286; Mitochondrial translation initiation.
DR Reactome; R-HSA-5389840; Mitochondrial translation elongation.
DR Reactome; R-HSA-5419276; Mitochondrial translation termination.
DR SignaLink; Q9Y2R5; -.
DR SIGNOR; Q9Y2R5; -.
DR BioGRID-ORCS; 51373; 128 hits in 1081 CRISPR screens.
DR ChiTaRS; MRPS17; human.
DR GeneWiki; MRPS17; -.
DR GenomeRNAi; 51373; -.
DR Pharos; Q9Y2R5; Tdark.
DR PRO; PR:Q9Y2R5; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q9Y2R5; protein.
DR Bgee; ENSG00000239789; Expressed in gastrocnemius and 101 other tissues.
DR ExpressionAtlas; Q9Y2R5; baseline and differential.
DR Genevisible; Q9Y2R5; HS.
DR GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
DR GO; GO:0005763; C:mitochondrial small ribosomal subunit; IDA:UniProtKB.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003735; F:structural constituent of ribosome; HDA:UniProtKB.
DR GO; GO:0032543; P:mitochondrial translation; HDA:UniProtKB.
DR GO; GO:0006412; P:translation; NAS:UniProtKB.
DR Gene3D; 2.40.50.140; -; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR000266; Ribosomal_S17/S11.
DR InterPro; IPR039193; S17mt.
DR PANTHER; PTHR24088; PTHR24088; 1.
DR Pfam; PF00366; Ribosomal_S17; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Mitochondrion; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein; RNA-binding; rRNA-binding; Transit peptide.
FT TRANSIT 1..20
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 21..130
FT /note="28S ribosomal protein S17, mitochondrial"
FT /id="PRO_0000030623"
SQ SEQUENCE 130 AA; 14502 MW; 5346917E78F7C6C3 CRC64;
MSVVRSSVHA RWIVGKVIGT KMQKTAKVRV TRLVLDPYLL KYFNKRKTYF AHDALQQCTV
GDIVLLRALP VPRAKHVKHE LAEIVFKVGK VIDPVTGKPC AGTTYLESPL SSETTQLSKN
LEELNISSAQ
