RT17_MOUSE
ID RT17_MOUSE Reviewed; 120 AA.
AC Q9CQE3;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 27-APR-2001, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=28S ribosomal protein S17, mitochondrial;
DE Short=MRP-S17;
DE Short=S17mt;
DE Flags: Precursor;
GN Name=Mrps17; Synonyms=Rpms17;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11402041; DOI=10.1074/jbc.m103236200;
RA Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A.,
RA Watanabe K.;
RT "Proteomic analysis of the mammalian mitochondrial ribosome. Identification
RT of protein components in the 28S small subunit.";
RL J. Biol. Chem. 276:33181-33195(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, Pancreas, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Component of the mitochondrial ribosome small subunit (28S)
CC which comprises a 12S rRNA and about 30 distinct proteins.
CC {ECO:0000250|UniProtKB:P82916}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P82916}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS17 family.
CC {ECO:0000305}.
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DR EMBL; AB049951; BAB41004.1; -; mRNA.
DR EMBL; AK009568; BAB26365.1; -; mRNA.
DR EMBL; AK003008; BAB22509.1; -; mRNA.
DR EMBL; AK007356; BAB24983.1; -; mRNA.
DR EMBL; BC003890; AAH03890.1; -; mRNA.
DR CCDS; CCDS19697.1; -.
DR RefSeq; NP_079726.1; NM_025450.4.
DR RefSeq; XP_006504383.1; XM_006504320.2.
DR RefSeq; XP_006504384.1; XM_006504321.2.
DR RefSeq; XP_006504385.1; XM_006504322.2.
DR RefSeq; XP_006504386.1; XM_006504323.2.
DR RefSeq; XP_006504387.1; XM_006504324.3.
DR RefSeq; XP_011239147.1; XM_011240845.2.
DR AlphaFoldDB; Q9CQE3; -.
DR SMR; Q9CQE3; -.
DR BioGRID; 211333; 2.
DR ComplexPortal; CPX-5301; 28S mitochondrial small ribosomal subunit.
DR IntAct; Q9CQE3; 1.
DR MINT; Q9CQE3; -.
DR STRING; 10090.ENSMUSP00000114012; -.
DR iPTMnet; Q9CQE3; -.
DR PhosphoSitePlus; Q9CQE3; -.
DR EPD; Q9CQE3; -.
DR MaxQB; Q9CQE3; -.
DR PaxDb; Q9CQE3; -.
DR PeptideAtlas; Q9CQE3; -.
DR PRIDE; Q9CQE3; -.
DR ProteomicsDB; 260739; -.
DR DNASU; 66258; -.
DR Ensembl; ENSMUST00000042191; ENSMUSP00000040281; ENSMUSG00000034211.
DR Ensembl; ENSMUST00000118420; ENSMUSP00000112993; ENSMUSG00000034211.
DR Ensembl; ENSMUST00000119576; ENSMUSP00000112779; ENSMUSG00000034211.
DR Ensembl; ENSMUST00000119604; ENSMUSP00000114012; ENSMUSG00000034211.
DR Ensembl; ENSMUST00000119985; ENSMUSP00000112762; ENSMUSG00000034211.
DR Ensembl; ENSMUST00000121339; ENSMUSP00000114125; ENSMUSG00000034211.
DR Ensembl; ENSMUST00000121813; ENSMUSP00000114059; ENSMUSG00000034211.
DR GeneID; 66258; -.
DR KEGG; mmu:66258; -.
DR UCSC; uc008ztb.1; mouse.
DR CTD; 51373; -.
DR MGI; MGI:1913508; Mrps17.
DR VEuPathDB; HostDB:ENSMUSG00000034211; -.
DR eggNOG; KOG3447; Eukaryota.
DR GeneTree; ENSGT00530000064130; -.
DR HOGENOM; CLU_073626_5_0_1; -.
DR InParanoid; Q9CQE3; -.
DR OMA; TVHAKWI; -.
DR OrthoDB; 1515865at2759; -.
DR PhylomeDB; Q9CQE3; -.
DR TreeFam; TF326484; -.
DR Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 66258; 16 hits in 76 CRISPR screens.
DR ChiTaRS; Mrps17; mouse.
DR PRO; PR:Q9CQE3; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q9CQE3; protein.
DR Bgee; ENSMUSG00000034211; Expressed in interventricular septum and 276 other tissues.
DR ExpressionAtlas; Q9CQE3; baseline and differential.
DR Genevisible; Q9CQE3; MM.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR GO; GO:0005763; C:mitochondrial small ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003735; F:structural constituent of ribosome; ISS:UniProtKB.
DR GO; GO:0032543; P:mitochondrial translation; ISS:UniProtKB.
DR Gene3D; 2.40.50.140; -; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR000266; Ribosomal_S17/S11.
DR InterPro; IPR039193; S17mt.
DR PANTHER; PTHR24088; PTHR24088; 1.
DR Pfam; PF00366; Ribosomal_S17; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW RNA-binding; rRNA-binding; Transit peptide.
FT TRANSIT 1..20
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 21..120
FT /note="28S ribosomal protein S17, mitochondrial"
FT /id="PRO_0000030624"
SQ SEQUENCE 120 AA; 13382 MW; 98D6C28EDC3065AD CRC64;
MSIVRSSVHA KWVVGKVIGT AMIKTAKVRA TRLVLDPYLL KYFNKRKTYF AHDALQQCSV
GDIVLLRALP VPRSKHVKHE LAEIIFKVGR VIDPVTGKPC AGTAYLESPL SEPREELKVS
