RT18A_BOVIN
ID RT18A_BOVIN Reviewed; 196 AA.
AC P82919; A6QLH4;
DT 19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 3.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=28S ribosomal protein S18a, mitochondrial;
DE Short=MRP-S18-a;
DE Short=Mrps18a;
DE Short=S18mt-a;
DE AltName: Full=28S ribosomal protein S18-3, mitochondrial;
DE Short=MRP-S18-3;
DE Flags: Precursor;
GN Name=MRPS18A;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000305};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hypothalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP PROTEIN SEQUENCE OF 35-47, SUBCELLULAR LOCATION, AND SUBUNIT.
RX PubMed=11402041; DOI=10.1074/jbc.m103236200;
RA Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A.,
RA Watanabe K.;
RT "Proteomic analysis of the mammalian mitochondrial ribosome. Identification
RT of protein components in the 28S small subunit.";
RL J. Biol. Chem. 276:33181-33195(2001).
RN [3] {ECO:0000305}
RP PROTEIN SEQUENCE OF 174-196, SUBCELLULAR LOCATION, AND SUBUNIT.
RC TISSUE=Liver;
RX PubMed=11279123; DOI=10.1074/jbc.m100727200;
RA Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.;
RT "The small subunit of the mammalian mitochondrial ribosome: identification
RT of the full complement of ribosomal proteins present.";
RL J. Biol. Chem. 276:19363-19374(2001).
RN [4] {ECO:0007744|PDB:3JD5}
RP STRUCTURE BY ELECTRON MICROSCOPY (7.00 ANGSTROMS), SUBCELLULAR LOCATION,
RP AND SUBUNIT.
RX PubMed=24799711; DOI=10.1073/pnas.1401657111;
RA Kaushal P.S., Sharma M.R., Booth T.M., Haque E.M., Tung C.S.,
RA Sanbonmatsu K.Y., Spremulli L.L., Agrawal R.K.;
RT "Cryo-EM structure of the small subunit of the mammalian mitochondrial
RT ribosome.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:7284-7289(2014).
CC -!- SUBUNIT: Component of the mitochondrial ribosome small subunit (28S)
CC which comprises a 12S rRNA and about 30 distinct proteins.
CC {ECO:0000269|PubMed:11279123, ECO:0000269|PubMed:11402041,
CC ECO:0000269|PubMed:24799711}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11279123,
CC ECO:0000269|PubMed:11402041, ECO:0000269|PubMed:24799711}.
CC -!- SIMILARITY: Belongs to the bacterial ribosomal protein bS18 family.
CC Mitochondrion-specific ribosomal protein mL66 subfamily. {ECO:0000305}.
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DR EMBL; BC147966; AAI47967.1; -; mRNA.
DR RefSeq; NP_001094699.1; NM_001101229.2.
DR PDB; 3JD5; EM; 7.00 A; R=1-196.
DR PDBsum; 3JD5; -.
DR AlphaFoldDB; P82919; -.
DR SMR; P82919; -.
DR CORUM; P82919; -.
DR IntAct; P82919; 1.
DR STRING; 9913.ENSBTAP00000051782; -.
DR PaxDb; P82919; -.
DR GeneID; 614102; -.
DR KEGG; bta:614102; -.
DR CTD; 55168; -.
DR eggNOG; KOG3162; Eukaryota.
DR InParanoid; P82919; -.
DR OrthoDB; 1619493at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
DR GO; GO:0005763; C:mitochondrial small ribosomal subunit; HDA:UniProtKB.
DR GO; GO:0070181; F:small ribosomal subunit rRNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; HDA:UniProtKB.
DR GO; GO:0032543; P:mitochondrial translation; HDA:UniProtKB.
DR Gene3D; 4.10.640.10; -; 1.
DR InterPro; IPR001648; Ribosomal_S18.
DR InterPro; IPR036870; Ribosomal_S18_sf.
DR PANTHER; PTHR13479; PTHR13479; 1.
DR Pfam; PF01084; Ribosomal_S18; 1.
DR SUPFAM; SSF46911; SSF46911; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Mitochondrion; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein; Transit peptide.
FT TRANSIT 1..34
FT /note="Mitochondrion"
FT /evidence="ECO:0000269|PubMed:11402041"
FT CHAIN 35..196
FT /note="28S ribosomal protein S18a, mitochondrial"
FT /id="PRO_0000111315"
SQ SEQUENCE 196 AA; 22281 MW; 0CAA7B308EAD5CF1 CRC64;
MAALNVLVSG CGRFLRGLLT GPTVTSWARP PARGFREVVE IQEGKTTIIE GRITGTPKES
PNPPNPSGQC PICRWNLKHK YSYEDVLLLS QFIRPHGGML PRSITGLCQE EHRKIEECVK
MAHRAGLLPN HRPKLPEGFF PKTRPRLNRY LTRWSPRSVK PIYNKGHRWN KVRMAVGSPL
LKDNVSYTGR PLVLYH