RT18C_MOUSE
ID RT18C_MOUSE Reviewed; 143 AA.
AC Q8R2L5; Q3UKN5; Q9D100;
DT 19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=28S ribosomal protein S18c, mitochondrial;
DE Short=MRP-S18-c;
DE Short=Mrps18-c;
DE Short=S18mt-c;
DE AltName: Full=28S ribosomal protein S18-1, mitochondrial;
DE Short=MRP-S18-1;
DE Flags: Precursor;
GN Name=Mrps18c;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Component of the mitochondrial ribosome small subunit (28S)
CC which comprises a 12S rRNA and about 30 distinct proteins.
CC {ECO:0000250|UniProtKB:P82917}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P82917}.
CC -!- SIMILARITY: Belongs to the bacterial ribosomal protein bS18 family.
CC {ECO:0000305}.
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DR EMBL; AK004139; BAB23188.1; -; mRNA.
DR EMBL; AK145935; BAE26766.1; -; mRNA.
DR EMBL; BC028442; AAH28442.1; -; mRNA.
DR CCDS; CCDS19468.1; -.
DR RefSeq; NP_081102.1; NM_026826.1.
DR AlphaFoldDB; Q8R2L5; -.
DR SMR; Q8R2L5; -.
DR ComplexPortal; CPX-5301; 28S mitochondrial small ribosomal subunit.
DR STRING; 10090.ENSMUSP00000016977; -.
DR iPTMnet; Q8R2L5; -.
DR PhosphoSitePlus; Q8R2L5; -.
DR EPD; Q8R2L5; -.
DR MaxQB; Q8R2L5; -.
DR PaxDb; Q8R2L5; -.
DR PeptideAtlas; Q8R2L5; -.
DR PRIDE; Q8R2L5; -.
DR ProteomicsDB; 262720; -.
DR Antibodypedia; 56067; 115 antibodies from 21 providers.
DR DNASU; 68735; -.
DR Ensembl; ENSMUST00000016977; ENSMUSP00000016977; ENSMUSG00000016833.
DR GeneID; 68735; -.
DR KEGG; mmu:68735; -.
DR UCSC; uc008yib.1; mouse.
DR CTD; 51023; -.
DR MGI; MGI:1915985; Mrps18c.
DR VEuPathDB; HostDB:ENSMUSG00000016833; -.
DR eggNOG; KOG3162; Eukaryota.
DR GeneTree; ENSGT00390000003791; -.
DR HOGENOM; CLU_139337_2_0_1; -.
DR InParanoid; Q8R2L5; -.
DR OMA; GYHKDLD; -.
DR OrthoDB; 1592020at2759; -.
DR PhylomeDB; Q8R2L5; -.
DR TreeFam; TF315059; -.
DR Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 68735; 17 hits in 73 CRISPR screens.
DR ChiTaRS; Mrps18c; mouse.
DR PRO; PR:Q8R2L5; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q8R2L5; protein.
DR Bgee; ENSMUSG00000016833; Expressed in dorsal pancreas and 274 other tissues.
DR ExpressionAtlas; Q8R2L5; baseline and differential.
DR Genevisible; Q8R2L5; MM.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR GO; GO:0005763; C:mitochondrial small ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0070181; F:small ribosomal subunit rRNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR Gene3D; 4.10.640.10; -; 1.
DR InterPro; IPR001648; Ribosomal_S18.
DR InterPro; IPR018275; Ribosomal_S18_CS.
DR InterPro; IPR036870; Ribosomal_S18_sf.
DR PANTHER; PTHR13479; PTHR13479; 1.
DR Pfam; PF01084; Ribosomal_S18; 1.
DR SUPFAM; SSF46911; SSF46911; 1.
DR TIGRFAMs; TIGR00165; S18; 1.
DR PROSITE; PS00057; RIBOSOMAL_S18; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW Transit peptide.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..143
FT /note="28S ribosomal protein S18c, mitochondrial"
FT /id="PRO_0000030630"
FT CONFLICT 37
FT /note="R -> Q (in Ref. 1; BAB23188)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 143 AA; 16275 MW; DD5926769541F2B6 CRC64;
MAALVALCSG IGRKNLTTAA GCFTDRGTQA VSVIWRRCFS QFEQVTSNED LPVPMENPYK
EPLKKCVLCE KRVDYKNVQL LSQFISPFTG CIYGRHITGL CGKKQREITK AIKRAQKMGF
MPVTYKDPAY LKDPRVCNIR YRE
