RT22_MOUSE
ID RT22_MOUSE Reviewed; 359 AA.
AC Q9CXW2; Q3U3T2; Q8VDG9; Q9D185;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 27-APR-2001, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=28S ribosomal protein S22, mitochondrial;
DE Short=MRP-S22;
DE Short=S22mt;
GN Name=Mrps22; Synonyms=Rpms22;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Embryo, and Embryonic head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP DISRUPTION PHENOTYPE.
RX PubMed=29566152; DOI=10.1093/hmg/ddy098;
RA Chen A., Tiosano D., Guran T., Baris H.N., Bayram Y., Mory A.,
RA Shapiro-Kulnane L., Hodges C.A., Akdemir Z.C., Turan S., Jhangiani S.N.,
RA van den Akker F., Hoppel C.L., Salz H.K., Lupski J.R., Buchner D.A.;
RT "Mutations in the mitochondrial ribosomal protein MRPS22 lead to primary
RT ovarian insufficiency.";
RL Hum. Mol. Genet. 27:1913-1926(2018).
CC -!- SUBUNIT: Component of the mitochondrial ribosome small subunit (28S)
CC which comprises a 12S rRNA and about 30 distinct proteins.
CC {ECO:0000250|UniProtKB:P82649}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P82649}.
CC -!- DISRUPTION PHENOTYPE: Heterozygous MRPS22 knockout mice are fertile and
CC show no overt abnormalities. Homozygous MRPS22 knockout results in
CC embryonic lethality. {ECO:0000269|PubMed:29566152}.
CC -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC mS22 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH21882.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK003836; BAB23027.2; -; mRNA.
DR EMBL; AK013925; BAB29061.1; -; mRNA.
DR EMBL; AK154600; BAE32703.1; -; mRNA.
DR EMBL; BC021882; AAH21882.1; ALT_INIT; mRNA.
DR EMBL; BC051198; AAH51198.1; -; mRNA.
DR CCDS; CCDS23427.1; -.
DR RefSeq; NP_079761.1; NM_025485.3.
DR AlphaFoldDB; Q9CXW2; -.
DR SMR; Q9CXW2; -.
DR BioGRID; 211091; 12.
DR ComplexPortal; CPX-5301; 28S mitochondrial small ribosomal subunit.
DR IntAct; Q9CXW2; 2.
DR MINT; Q9CXW2; -.
DR STRING; 10090.ENSMUSP00000035034; -.
DR iPTMnet; Q9CXW2; -.
DR PhosphoSitePlus; Q9CXW2; -.
DR EPD; Q9CXW2; -.
DR jPOST; Q9CXW2; -.
DR MaxQB; Q9CXW2; -.
DR PaxDb; Q9CXW2; -.
DR PeptideAtlas; Q9CXW2; -.
DR PRIDE; Q9CXW2; -.
DR ProteomicsDB; 257047; -.
DR Antibodypedia; 1600; 189 antibodies from 26 providers.
DR Ensembl; ENSMUST00000035034; ENSMUSP00000035034; ENSMUSG00000032459.
DR GeneID; 64655; -.
DR KEGG; mmu:64655; -.
DR UCSC; uc009rdn.3; mouse.
DR CTD; 56945; -.
DR MGI; MGI:1928137; Mrps22.
DR VEuPathDB; HostDB:ENSMUSG00000032459; -.
DR eggNOG; KOG3890; Eukaryota.
DR GeneTree; ENSGT00390000006095; -.
DR HOGENOM; CLU_053702_1_0_1; -.
DR InParanoid; Q9CXW2; -.
DR OMA; TTKRMNQ; -.
DR OrthoDB; 845271at2759; -.
DR PhylomeDB; Q9CXW2; -.
DR TreeFam; TF312882; -.
DR Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 64655; 23 hits in 74 CRISPR screens.
DR ChiTaRS; Mrps22; mouse.
DR PRO; PR:Q9CXW2; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q9CXW2; protein.
DR Bgee; ENSMUSG00000032459; Expressed in primary oocyte and 259 other tissues.
DR Genevisible; Q9CXW2; MM.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR GO; GO:0005763; C:mitochondrial small ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:MGI.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR InterPro; IPR019374; Ribosomal_S22_mit.
DR PANTHER; PTHR13071; PTHR13071; 1.
DR Pfam; PF10245; MRP-S22; 1.
PE 1: Evidence at protein level;
KW Acetylation; Mitochondrion; Phosphoprotein; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..359
FT /note="28S ribosomal protein S22, mitochondrial"
FT /id="PRO_0000087704"
FT REGION 40..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 54
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P82650"
FT MOD_RES 210
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P82650"
SQ SEQUENCE 359 AA; 41192 MW; C258AD152738F1C7 CRC64;
MAAVRTPLSL WRFQLGSRRA RRVCTRATAQ RHPDALLATR PQPFEVGQPR RLLSSEAESG
SSEVKKPAFM DEEVQRILTK ITGLDLQKTF RPAIQPLKPP TYKLMTQAQL EEATRLAVEA
AKVRLKMPPV LEERKPINDV LAEDKILEGT ETNKYVFTDI SYNIPHRERF IVVREPSGTL
RKASWEERDR VIQIYFPKEG RRVLPPVIFK DENLKTMYSQ DRHADVLNLC VAQFEPDSAE
YIKVHHQTYE DIDRHGKYEL LRSTRHFGGM AWYFVNKKKI DGLLIDQIQR DLVDDATSLV
QLYHMLHPDG QSAQEAKEQA AEGVDLIKVF AKTEAQRGAY IELALQTYQE IVTSHSAAS
