RT23_MOUSE
ID RT23_MOUSE Reviewed; 177 AA.
AC Q8VE22; Q9CXH1;
DT 23-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=28S ribosomal protein S23, mitochondrial;
DE Short=MRP-S23;
DE Short=S23mt;
GN Name=Mrps23 {ECO:0000312|MGI:MGI:1928138};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000269|PubMed:16141072};
RC TISSUE=Head {ECO:0000269|PubMed:16141072};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland {ECO:0000269|PubMed:15489334};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-83, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
CC -!- SUBUNIT: Component of the mitochondrial ribosome small subunit (28S)
CC which comprises a 12S rRNA and about 30 distinct proteins.
CC {ECO:0000250|UniProtKB:Q2NL27}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q2NL27}.
CC -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC mS23 family. {ECO:0000305}.
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DR EMBL; AK014375; BAB29307.2; -; mRNA.
DR EMBL; BC019980; AAH19980.1; -; mRNA.
DR CCDS; CCDS25227.1; -.
DR RefSeq; NP_001278199.1; NM_001291270.1.
DR RefSeq; NP_001278200.1; NM_001291271.1.
DR RefSeq; NP_001278201.1; NM_001291272.1.
DR RefSeq; NP_001278202.1; NM_001291273.1.
DR RefSeq; NP_077136.2; NM_024174.6.
DR AlphaFoldDB; Q8VE22; -.
DR SMR; Q8VE22; -.
DR BioGRID; 211092; 15.
DR ComplexPortal; CPX-5301; 28S mitochondrial small ribosomal subunit.
DR STRING; 10090.ENSMUSP00000024486; -.
DR iPTMnet; Q8VE22; -.
DR PhosphoSitePlus; Q8VE22; -.
DR EPD; Q8VE22; -.
DR jPOST; Q8VE22; -.
DR MaxQB; Q8VE22; -.
DR PaxDb; Q8VE22; -.
DR PeptideAtlas; Q8VE22; -.
DR PRIDE; Q8VE22; -.
DR ProteomicsDB; 260942; -.
DR Antibodypedia; 18338; 133 antibodies from 22 providers.
DR Ensembl; ENSMUST00000024486; ENSMUSP00000024486; ENSMUSG00000023723.
DR GeneID; 64656; -.
DR KEGG; mmu:64656; -.
DR UCSC; uc007kvi.2; mouse.
DR CTD; 51649; -.
DR MGI; MGI:1928138; Mrps23.
DR VEuPathDB; HostDB:ENSMUSG00000023723; -.
DR eggNOG; ENOG502RZIC; Eukaryota.
DR GeneTree; ENSGT00390000009030; -.
DR InParanoid; Q8VE22; -.
DR OMA; RIRAKYY; -.
DR OrthoDB; 1115569at2759; -.
DR PhylomeDB; Q8VE22; -.
DR TreeFam; TF106116; -.
DR Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 64656; 12 hits in 74 CRISPR screens.
DR PRO; PR:Q8VE22; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8VE22; protein.
DR Bgee; ENSMUSG00000023723; Expressed in embryonic brain and 71 other tissues.
DR ExpressionAtlas; Q8VE22; baseline and differential.
DR Genevisible; Q8VE22; MM.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR GO; GO:0005763; C:mitochondrial small ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0031965; C:nuclear membrane; ISO:MGI.
DR GO; GO:0003735; F:structural constituent of ribosome; ISS:MGI.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR InterPro; IPR019520; Ribosomal_S23.
DR InterPro; IPR023611; Ribosomal_S23/S25_mit.
DR PANTHER; PTHR15925; PTHR15925; 1.
DR Pfam; PF10484; MRP-S23; 1.
PE 1: Evidence at protein level;
KW Acetylation; Mitochondrion; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3D9"
FT CHAIN 2..177
FT /note="28S ribosomal protein S23, mitochondrial"
FT /id="PRO_0000087706"
FT REGION 145..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..165
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3D9"
FT MOD_RES 83
FT /note="N6-succinyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
FT MOD_RES 102
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3D9"
SQ SEQUENCE 177 AA; 20348 MW; F974059661BDC1A7 CRC64;
MAGSRLETVG SVFSRTRDLM RAGVLKEKPL WYDIYKAFPP LREPVFRRPR LRYGKAKADI
QDIFYQEDQI RAKFFATYGS GQKAFDLFNP NFKSTCQRFV EKYTELQNLG ETDEEKLFVE
TGKALLAEGI ILRRVREART VSVRLQASSE GHEPQEDDDL AQRGQVKQEP ETAPSPP
