RT24_HUMAN
ID RT24_HUMAN Reviewed; 167 AA.
AC Q96EL2; A4D1U9; P82668; Q96Q23; Q9P047;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=28S ribosomal protein S24, mitochondrial;
DE Short=MRP-S24;
DE Short=S24mt;
DE AltName: Full=Mitochondrial small ribosomal subunit protein uS3m {ECO:0000303|PubMed:25838379};
DE AltName: Full=bMRP-47;
DE Short=bMRP47;
DE Flags: Precursor;
GN Name=MRPS24; ORFNames=HSPC335;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Umbilical cord blood;
RX PubMed=9653160; DOI=10.1073/pnas.95.14.8175;
RA Mao M., Fu G., Wu J.-S., Zhang Q.-H., Zhou J., Kan L.-X., Huang Q.-H.,
RA He K.-L., Gu B.-W., Han Z.-G., Shen Y., Gu J., Yu Y.-P., Xu S.-H.,
RA Wang Y.-X., Chen S.-J., Chen Z.;
RT "Identification of genes expressed in human CD34(+) hematopoietic
RT stem/progenitor cells by expressed sequence tags and efficient full-length
RT cDNA cloning.";
RL Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 75-112.
RX PubMed=11543634; DOI=10.1006/geno.2001.6622;
RA Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S.,
RA Watanabe K., Tanaka T.;
RT "The human mitochondrial ribosomal protein genes: mapping of 54 genes to
RT the chromosomes and implications for human disorders.";
RL Genomics 77:65-70(2001).
RN [6]
RP IDENTIFICATION.
RX PubMed=10938081; DOI=10.1074/jbc.m003596200;
RA Koc E.C., Burkhart W., Blackburn K., Moseley A., Koc H., Spremulli L.L.;
RT "A proteomics approach to the identification of mammalian mitochondrial
RT small subunit ribosomal proteins.";
RL J. Biol. Chem. 275:32585-32591(2000).
RN [7]
RP IDENTIFICATION.
RX PubMed=11402041; DOI=10.1074/jbc.m103236200;
RA Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A.,
RA Watanabe K.;
RT "Proteomic analysis of the mammalian mitochondrial ribosome. Identification
RT of protein components in the 28S small subunit.";
RL J. Biol. Chem. 276:33181-33195(2001).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
RN [10]
RP STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS), SUBUNIT, AND SUBCELLULAR
RP LOCATION.
RX PubMed=25838379; DOI=10.1126/science.aaa1193;
RA Amunts A., Brown A., Toots J., Scheres S.H., Ramakrishnan V.;
RT "Ribosome. The structure of the human mitochondrial ribosome.";
RL Science 348:95-98(2015).
CC -!- SUBUNIT: Component of the mitochondrial small ribosomal subunit (mt-
CC SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small
CC (28S) and a large (39S) subunit. The 28S small subunit contains a 12S
CC ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large
CC subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial
CC valine transfer RNA (mt-tRNA(Val)), which plays an integral structural
CC role, and 52 different proteins. {ECO:0000269|PubMed:25838379}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS3 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF29013.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF161453; AAF29013.1; ALT_FRAME; mRNA.
DR EMBL; CH236951; EAL24009.1; -; Genomic_DNA.
DR EMBL; CH471073; EAW94173.1; -; Genomic_DNA.
DR EMBL; BC012167; AAH12167.1; -; mRNA.
DR EMBL; BC054865; AAH54865.1; -; mRNA.
DR EMBL; AB061207; BAB54957.1; -; Genomic_DNA.
DR CCDS; CCDS5473.1; -.
DR RefSeq; NP_114403.1; NM_032014.2.
DR PDB; 3J9M; EM; 3.50 A; AC=1-167.
DR PDB; 6NU2; EM; 3.90 A; AC=36-167.
DR PDB; 6NU3; EM; 4.40 A; AC=1-167.
DR PDB; 6RW4; EM; 2.97 A; C=1-167.
DR PDB; 6RW5; EM; 3.14 A; C=1-167.
DR PDB; 6VLZ; EM; 2.97 A; AC=1-167.
DR PDB; 6VMI; EM; 2.96 A; AC=1-167.
DR PDB; 6ZM5; EM; 2.89 A; AC=1-167.
DR PDB; 6ZM6; EM; 2.59 A; AC=1-167.
DR PDB; 6ZS9; EM; 4.00 A; AC=1-167.
DR PDB; 6ZSA; EM; 4.00 A; AC=1-167.
DR PDB; 6ZSB; EM; 4.50 A; AC=1-167.
DR PDB; 6ZSC; EM; 3.50 A; AC=1-167.
DR PDB; 6ZSD; EM; 3.70 A; AC=1-167.
DR PDB; 6ZSE; EM; 5.00 A; AC=1-167.
DR PDB; 6ZSG; EM; 4.00 A; AC=1-167.
DR PDB; 7A5F; EM; 4.40 A; C6=1-167.
DR PDB; 7A5G; EM; 4.33 A; C6=1-167.
DR PDB; 7A5I; EM; 3.70 A; C6=1-167.
DR PDB; 7A5K; EM; 3.70 A; C6=1-167.
DR PDB; 7L08; EM; 3.49 A; AC=1-167.
DR PDB; 7OG4; EM; 3.80 A; AC=1-167.
DR PDBsum; 3J9M; -.
DR PDBsum; 6NU2; -.
DR PDBsum; 6NU3; -.
DR PDBsum; 6RW4; -.
DR PDBsum; 6RW5; -.
DR PDBsum; 6VLZ; -.
DR PDBsum; 6VMI; -.
DR PDBsum; 6ZM5; -.
DR PDBsum; 6ZM6; -.
DR PDBsum; 6ZS9; -.
DR PDBsum; 6ZSA; -.
DR PDBsum; 6ZSB; -.
DR PDBsum; 6ZSC; -.
DR PDBsum; 6ZSD; -.
DR PDBsum; 6ZSE; -.
DR PDBsum; 6ZSG; -.
DR PDBsum; 7A5F; -.
DR PDBsum; 7A5G; -.
DR PDBsum; 7A5I; -.
DR PDBsum; 7A5K; -.
DR PDBsum; 7L08; -.
DR PDBsum; 7OG4; -.
DR AlphaFoldDB; Q96EL2; -.
DR SMR; Q96EL2; -.
DR BioGRID; 122357; 283.
DR ComplexPortal; CPX-5225; 28S mitochondrial small ribosomal subunit.
DR CORUM; Q96EL2; -.
DR IntAct; Q96EL2; 45.
DR MINT; Q96EL2; -.
DR STRING; 9606.ENSP00000318158; -.
DR GlyGen; Q96EL2; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q96EL2; -.
DR PhosphoSitePlus; Q96EL2; -.
DR BioMuta; MRPS24; -.
DR EPD; Q96EL2; -.
DR jPOST; Q96EL2; -.
DR MassIVE; Q96EL2; -.
DR MaxQB; Q96EL2; -.
DR PaxDb; Q96EL2; -.
DR PeptideAtlas; Q96EL2; -.
DR PRIDE; Q96EL2; -.
DR ProteomicsDB; 76423; -.
DR TopDownProteomics; Q96EL2; -.
DR Antibodypedia; 44496; 117 antibodies from 24 providers.
DR DNASU; 64951; -.
DR Ensembl; ENST00000317534.6; ENSP00000318158.5; ENSG00000062582.14.
DR GeneID; 64951; -.
DR KEGG; hsa:64951; -.
DR MANE-Select; ENST00000317534.6; ENSP00000318158.5; NM_032014.3; NP_114403.1.
DR UCSC; uc003tit.2; human.
DR CTD; 64951; -.
DR GeneCards; MRPS24; -.
DR HGNC; HGNC:14510; MRPS24.
DR HPA; ENSG00000062582; Tissue enhanced (skeletal).
DR MIM; 611986; gene.
DR neXtProt; NX_Q96EL2; -.
DR OpenTargets; ENSG00000062582; -.
DR PharmGKB; PA31012; -.
DR VEuPathDB; HostDB:ENSG00000062582; -.
DR eggNOG; ENOG502RXU1; Eukaryota.
DR GeneTree; ENSGT00390000011179; -.
DR HOGENOM; CLU_134150_0_0_1; -.
DR InParanoid; Q96EL2; -.
DR OMA; PPHFIAH; -.
DR OrthoDB; 1365248at2759; -.
DR PhylomeDB; Q96EL2; -.
DR TreeFam; TF324311; -.
DR PathwayCommons; Q96EL2; -.
DR Reactome; R-HSA-5368286; Mitochondrial translation initiation.
DR Reactome; R-HSA-5389840; Mitochondrial translation elongation.
DR Reactome; R-HSA-5419276; Mitochondrial translation termination.
DR SignaLink; Q96EL2; -.
DR SIGNOR; Q96EL2; -.
DR BioGRID-ORCS; 64951; 390 hits in 1090 CRISPR screens.
DR GeneWiki; MRPS24; -.
DR GenomeRNAi; 64951; -.
DR Pharos; Q96EL2; Tdark.
DR PRO; PR:Q96EL2; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q96EL2; protein.
DR Bgee; ENSG00000062582; Expressed in gastrocnemius and 99 other tissues.
DR ExpressionAtlas; Q96EL2; baseline and differential.
DR Genevisible; Q96EL2; HS.
DR GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
DR GO; GO:0005763; C:mitochondrial small ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR GO; GO:0003735; F:structural constituent of ribosome; ISS:UniProtKB.
DR GO; GO:0032543; P:mitochondrial translation; ISS:UniProtKB.
DR InterPro; IPR026146; MRPS24.
DR PANTHER; PTHR21244; PTHR21244; 1.
DR Pfam; PF14955; MRP-S24; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Mitochondrion; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein; Transit peptide.
FT TRANSIT 1..35
FT /note="Mitochondrion"
FT /evidence="ECO:0000250"
FT CHAIN 36..167
FT /note="28S ribosomal protein S24, mitochondrial"
FT /id="PRO_0000273066"
FT VARIANT 97
FT /note="W -> R (in dbSNP:rs670573)"
FT /id="VAR_030077"
SQ SEQUENCE 167 AA; 19015 MW; D48DCB3803CFB37E CRC64;
MAASVCSGLL GPRVLSWSRE LPCAWRALHT SPVCAKNRAA RVRVSKGDKP VTYEEAHAPH
YIAHRKGWLS LHTGNLDGED HAAERTVEDV FLRKFMWGTF PGCLADQLVL KRRGNQLEIC
AVVLRQLSPH KYYFLVGYSE TLLSYFYKCP VRLHLQTVPS KVVYKYL
