ID   RT25_MOUSE              Reviewed;         171 AA.
AC   Q9D125; Q9CYY8;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   27-APR-2001, sequence version 1.
DT   03-AUG-2022, entry version 142.
DE   RecName: Full=28S ribosomal protein S25, mitochondrial;
DE            Short=MRP-S25;
DE            Short=S25mt;
GN   Name=Mrps25; Synonyms=Rpms25;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Embryo;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PROTEIN SEQUENCE OF 12-18, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=OF1; TISSUE=Hippocampus;
RA   Lubec G., Sunyer B., Chen W.-Q.;
RL   Submitted (JAN-2009) to UniProtKB.
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Spleen, and
RC   Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBUNIT: Component of the mitochondrial ribosome small subunit (28S)
CC       which comprises a 12S rRNA and about 30 distinct proteins.
CC       {ECO:0000250|UniProtKB:P82669}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P82669}.
CC   -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC       mS25 family. {ECO:0000305}.
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DR   EMBL; AK004037; BAB23136.1; -; mRNA.
DR   EMBL; AK013196; BAB28705.1; -; mRNA.
DR   EMBL; BC022953; AAH22953.1; -; mRNA.
DR   CCDS; CCDS20373.1; -.
DR   RefSeq; NP_079854.2; NM_025578.4.
DR   AlphaFoldDB; Q9D125; -.
DR   SMR; Q9D125; -.
DR   BioGRID; 211094; 3.
DR   ComplexPortal; CPX-5301; 28S mitochondrial small ribosomal subunit.
DR   STRING; 10090.ENSMUSP00000114402; -.
DR   iPTMnet; Q9D125; -.
DR   PhosphoSitePlus; Q9D125; -.
DR   EPD; Q9D125; -.
DR   MaxQB; Q9D125; -.
DR   PaxDb; Q9D125; -.
DR   PRIDE; Q9D125; -.
DR   ProteomicsDB; 256636; -.
DR   Antibodypedia; 26653; 265 antibodies from 28 providers.
DR   DNASU; 64658; -.
DR   Ensembl; ENSMUST00000140438; ENSMUSP00000114402; ENSMUSG00000014551.
DR   GeneID; 64658; -.
DR   KEGG; mmu:64658; -.
DR   UCSC; uc009cyu.1; mouse.
DR   CTD; 64432; -.
DR   MGI; MGI:1928140; Mrps25.
DR   VEuPathDB; HostDB:ENSMUSG00000014551; -.
DR   eggNOG; KOG4079; Eukaryota.
DR   GeneTree; ENSGT00640000091558; -.
DR   HOGENOM; CLU_094727_0_0_1; -.
DR   InParanoid; Q9D125; -.
DR   OMA; QIMLFRN; -.
DR   OrthoDB; 1438394at2759; -.
DR   PhylomeDB; Q9D125; -.
DR   TreeFam; TF300292; -.
DR   Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR   Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR   BioGRID-ORCS; 64658; 25 hits in 73 CRISPR screens.
DR   ChiTaRS; Mrps25; mouse.
DR   PRO; PR:Q9D125; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; Q9D125; protein.
DR   Bgee; ENSMUSG00000014551; Expressed in ileal epithelium and 259 other tissues.
DR   Genevisible; Q9D125; MM.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR   GO; GO:0005763; C:mitochondrial small ribosomal subunit; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR   GO; GO:0003735; F:structural constituent of ribosome; ISO:MGI.
DR   GO; GO:0032543; P:mitochondrial translation; IC:MGI.
DR   InterPro; IPR040049; MRPS25.
DR   InterPro; IPR007741; Ribosome/NADH_DH.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR13274; PTHR13274; 1.
DR   Pfam; PF05047; L51_S25_CI-B8; 1.
DR   SMART; SM00916; L51_S25_CI-B8; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Mitochondrion; Reference proteome;
KW   Ribonucleoprotein; Ribosomal protein.
FT   CHAIN           1..171
FT                   /note="28S ribosomal protein S25, mitochondrial"
FT                   /id="PRO_0000087709"
FT   CONFLICT        60
FT                   /note="P -> S (in Ref. 1; BAB28705)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   171 AA;  19920 MW;  F7CD5B07163FB14A CRC64;
     MPMKGRFPIR RTLQYLGRGD VVFKESVKIM TVNYNTYGEL GEGARKFVFF NIPQIQYKNP
     WVQIMMFKNM TPSPFLRFYL DSGEQVLVDV ETKSNKEIME HIKKILGKKE ETLREEELEK
     QQRFHPGNFG PRKYCLRECM CEVEGQVPCP GLVPLPKEMT GKYKAALKAS T