RT26_HUMAN
ID RT26_HUMAN Reviewed; 205 AA.
AC Q9BYN8; Q96Q58;
DT 01-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=28S ribosomal protein S26, mitochondrial;
DE Short=MRP-S26;
DE Short=S26mt;
DE AltName: Full=28S ribosomal protein S13, mitochondrial;
DE Short=MRP-S13;
DE Short=S13mt;
DE AltName: Full=Mitochondrial small ribosomal subunit protein mS26 {ECO:0000303|PubMed:25838379};
DE Flags: Precursor;
GN Name=MRPS26; Synonyms=C20orf193, RPMS13;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE OF 162-192.
RX PubMed=11543634; DOI=10.1006/geno.2001.6622;
RA Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S.,
RA Watanabe K., Tanaka T.;
RT "The human mitochondrial ribosomal protein genes: mapping of 54 genes to
RT the chromosomes and implications for human disorders.";
RL Genomics 77:65-70(2001).
RN [4]
RP IDENTIFICATION.
RX PubMed=11279123; DOI=10.1074/jbc.m100727200;
RA Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.;
RT "The small subunit of the mammalian mitochondrial ribosome: identification
RT of the full complement of ribosomal proteins present.";
RL J. Biol. Chem. 276:19363-19374(2001).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
RN [7]
RP STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS), SUBUNIT, AND SUBCELLULAR
RP LOCATION.
RX PubMed=25838379; DOI=10.1126/science.aaa1193;
RA Amunts A., Brown A., Toots J., Scheres S.H., Ramakrishnan V.;
RT "Ribosome. The structure of the human mitochondrial ribosome.";
RL Science 348:95-98(2015).
CC -!- SUBUNIT: Component of the mitochondrial small ribosomal subunit (mt-
CC SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small
CC (28S) and a large (39S) subunit. The 28S small subunit contains a 12S
CC ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large
CC subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial
CC valine transfer RNA (mt-tRNA(Val)), which plays an integral structural
CC role, and 52 different proteins. {ECO:0000269|PubMed:25838379}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379}.
CC -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC mS26 family. {ECO:0000305}.
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DR EMBL; AL121905; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC013018; AAH13018.1; -; mRNA.
DR EMBL; AB051354; BAB54943.1; -; Genomic_DNA.
DR CCDS; CCDS13043.1; -.
DR RefSeq; NP_110438.1; NM_030811.3.
DR PDB; 3J9M; EM; 3.50 A; AU=1-205.
DR PDB; 6NU2; EM; 3.90 A; AU=27-199.
DR PDB; 6NU3; EM; 4.40 A; AU=1-205.
DR PDB; 6RW4; EM; 2.97 A; U=1-205.
DR PDB; 6RW5; EM; 3.14 A; U=1-205.
DR PDB; 6VLZ; EM; 2.97 A; AU=1-205.
DR PDB; 6VMI; EM; 2.96 A; AU=1-205.
DR PDB; 6ZM5; EM; 2.89 A; AU=1-205.
DR PDB; 6ZM6; EM; 2.59 A; AU=1-205.
DR PDB; 6ZS9; EM; 4.00 A; AU=1-205.
DR PDB; 6ZSA; EM; 4.00 A; AU=1-205.
DR PDB; 6ZSB; EM; 4.50 A; AU=1-205.
DR PDB; 6ZSC; EM; 3.50 A; AU=1-205.
DR PDB; 6ZSD; EM; 3.70 A; AU=1-205.
DR PDB; 6ZSE; EM; 5.00 A; AU=1-205.
DR PDB; 6ZSG; EM; 4.00 A; AU=1-205.
DR PDB; 7A5F; EM; 4.40 A; U6=1-205.
DR PDB; 7A5G; EM; 4.33 A; U6=1-205.
DR PDB; 7A5I; EM; 3.70 A; U6=1-205.
DR PDB; 7A5K; EM; 3.70 A; U6=1-205.
DR PDB; 7L08; EM; 3.49 A; AU=1-205.
DR PDB; 7OG4; EM; 3.80 A; AU=1-205.
DR PDBsum; 3J9M; -.
DR PDBsum; 6NU2; -.
DR PDBsum; 6NU3; -.
DR PDBsum; 6RW4; -.
DR PDBsum; 6RW5; -.
DR PDBsum; 6VLZ; -.
DR PDBsum; 6VMI; -.
DR PDBsum; 6ZM5; -.
DR PDBsum; 6ZM6; -.
DR PDBsum; 6ZS9; -.
DR PDBsum; 6ZSA; -.
DR PDBsum; 6ZSB; -.
DR PDBsum; 6ZSC; -.
DR PDBsum; 6ZSD; -.
DR PDBsum; 6ZSE; -.
DR PDBsum; 6ZSG; -.
DR PDBsum; 7A5F; -.
DR PDBsum; 7A5G; -.
DR PDBsum; 7A5I; -.
DR PDBsum; 7A5K; -.
DR PDBsum; 7L08; -.
DR PDBsum; 7OG4; -.
DR AlphaFoldDB; Q9BYN8; -.
DR SMR; Q9BYN8; -.
DR BioGRID; 122356; 433.
DR ComplexPortal; CPX-5225; 28S mitochondrial small ribosomal subunit.
DR CORUM; Q9BYN8; -.
DR IntAct; Q9BYN8; 77.
DR MINT; Q9BYN8; -.
DR STRING; 9606.ENSP00000369682; -.
DR GlyGen; Q9BYN8; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9BYN8; -.
DR MetOSite; Q9BYN8; -.
DR PhosphoSitePlus; Q9BYN8; -.
DR BioMuta; MRPS26; -.
DR DMDM; 28201886; -.
DR EPD; Q9BYN8; -.
DR jPOST; Q9BYN8; -.
DR MassIVE; Q9BYN8; -.
DR MaxQB; Q9BYN8; -.
DR PaxDb; Q9BYN8; -.
DR PeptideAtlas; Q9BYN8; -.
DR PRIDE; Q9BYN8; -.
DR ProteomicsDB; 79673; -.
DR TopDownProteomics; Q9BYN8; -.
DR Antibodypedia; 48846; 102 antibodies from 24 providers.
DR DNASU; 64949; -.
DR Ensembl; ENST00000380325.4; ENSP00000369682.3; ENSG00000125901.6.
DR GeneID; 64949; -.
DR KEGG; hsa:64949; -.
DR MANE-Select; ENST00000380325.4; ENSP00000369682.3; NM_030811.4; NP_110438.1.
DR UCSC; uc002whs.4; human.
DR CTD; 64949; -.
DR GeneCards; MRPS26; -.
DR HGNC; HGNC:14045; MRPS26.
DR HPA; ENSG00000125901; Low tissue specificity.
DR MIM; 611988; gene.
DR neXtProt; NX_Q9BYN8; -.
DR OpenTargets; ENSG00000125901; -.
DR PharmGKB; PA31014; -.
DR VEuPathDB; HostDB:ENSG00000125901; -.
DR eggNOG; KOG4691; Eukaryota.
DR GeneTree; ENSGT00390000008453; -.
DR HOGENOM; CLU_104778_0_0_1; -.
DR InParanoid; Q9BYN8; -.
DR OMA; RKPRWLP; -.
DR OrthoDB; 1623955at2759; -.
DR PhylomeDB; Q9BYN8; -.
DR TreeFam; TF316309; -.
DR PathwayCommons; Q9BYN8; -.
DR Reactome; R-HSA-5368286; Mitochondrial translation initiation.
DR Reactome; R-HSA-5389840; Mitochondrial translation elongation.
DR Reactome; R-HSA-5419276; Mitochondrial translation termination.
DR SignaLink; Q9BYN8; -.
DR SIGNOR; Q9BYN8; -.
DR BioGRID-ORCS; 64949; 302 hits in 1076 CRISPR screens.
DR ChiTaRS; MRPS26; human.
DR GeneWiki; MRPS26; -.
DR GenomeRNAi; 64949; -.
DR Pharos; Q9BYN8; Tdark.
DR PRO; PR:Q9BYN8; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9BYN8; protein.
DR Bgee; ENSG00000125901; Expressed in adenohypophysis and 182 other tissues.
DR Genevisible; Q9BYN8; HS.
DR GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
DR GO; GO:0005763; C:mitochondrial small ribosomal subunit; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR InterPro; IPR026140; MRPS26.
DR PANTHER; PTHR21035; PTHR21035; 1.
DR Pfam; PF14943; MRP-S26; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Mitochondrion; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein; Transit peptide.
FT TRANSIT 1..27
FT /note="Mitochondrion"
FT /evidence="ECO:0000250"
FT CHAIN 28..205
FT /note="28S ribosomal protein S26, mitochondrial"
FT /id="PRO_0000030591"
SQ SEQUENCE 205 AA; 24212 MW; F40EF470813840EF CRC64;
MLRALSRLGA GTPCRPRAPL VLPARGRKTR HDPLAKSKIE RVNMPPAVDP AEFFVLMERY
QHYRQTVRAL RMEFVSEVQR KVHEARAGVL AERKALKDAA EHRELMAWNQ AENRRLHELR
IARLRQEERE QEQRQALEQA RKAEEVQAWA QRKEREVLQL QEEVKNFITR ENLEARVEAA
LDSRKNYNWA ITREGLVVRP QRRDS
