RT28_MOUSE
ID RT28_MOUSE Reviewed; 186 AA.
AC Q9CY16; Q8R2K6;
DT 26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=28S ribosomal protein S28, mitochondrial;
DE Short=MRP-S28;
DE Short=S28mt;
DE Flags: Precursor;
GN Name=Mrps28;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryonic liver;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Kidney, Liver, and Pancreas;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Component of the mitochondrial ribosome small subunit (28S)
CC which comprises a 12S rRNA and about 30 distinct proteins.
CC {ECO:0000250|UniProtKB:P82928}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P82928}.
CC -!- SIMILARITY: Belongs to the bacterial ribosomal protein bS1 family.
CC {ECO:0000305}.
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DR EMBL; AK011036; BAB27349.1; -; mRNA.
DR EMBL; BC028530; AAH28530.1; -; mRNA.
DR CCDS; CCDS17233.1; -.
DR RefSeq; NP_079710.3; NM_025434.3.
DR AlphaFoldDB; Q9CY16; -.
DR SMR; Q9CY16; -.
DR BioGRID; 211312; 1.
DR ComplexPortal; CPX-5301; 28S mitochondrial small ribosomal subunit.
DR STRING; 10090.ENSMUSP00000038305; -.
DR iPTMnet; Q9CY16; -.
DR PhosphoSitePlus; Q9CY16; -.
DR EPD; Q9CY16; -.
DR jPOST; Q9CY16; -.
DR MaxQB; Q9CY16; -.
DR PaxDb; Q9CY16; -.
DR PeptideAtlas; Q9CY16; -.
DR PRIDE; Q9CY16; -.
DR ProteomicsDB; 260861; -.
DR Antibodypedia; 12414; 102 antibodies from 22 providers.
DR DNASU; 66230; -.
DR Ensembl; ENSMUST00000042148; ENSMUSP00000038305; ENSMUSG00000040269.
DR GeneID; 66230; -.
DR KEGG; mmu:66230; -.
DR UCSC; uc008ooq.2; mouse.
DR CTD; 28957; -.
DR MGI; MGI:1913480; Mrps28.
DR VEuPathDB; HostDB:ENSMUSG00000040269; -.
DR eggNOG; KOG4078; Eukaryota.
DR GeneTree; ENSGT00390000001057; -.
DR HOGENOM; CLU_109102_2_0_1; -.
DR InParanoid; Q9CY16; -.
DR OMA; LPEDNQT; -.
DR OrthoDB; 1566742at2759; -.
DR PhylomeDB; Q9CY16; -.
DR TreeFam; TF315097; -.
DR Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 66230; 14 hits in 73 CRISPR screens.
DR ChiTaRS; Mrps28; mouse.
DR PRO; PR:Q9CY16; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q9CY16; protein.
DR Bgee; ENSMUSG00000040269; Expressed in floor plate of midbrain and 248 other tissues.
DR Genevisible; Q9CY16; MM.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR GO; GO:0005763; C:mitochondrial small ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0032543; P:mitochondrial translation; ISS:UniProtKB.
DR InterPro; IPR019375; Ribosomal_S28_mit.
DR PANTHER; PTHR13447; PTHR13447; 1.
DR Pfam; PF10246; MRP-S35; 1.
PE 1: Evidence at protein level;
KW Acetylation; Mitochondrion; Phosphoprotein; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein; Transit peptide.
FT TRANSIT 1..70
FT /note="Mitochondrion"
FT /evidence="ECO:0000250"
FT CHAIN 71..186
FT /note="28S ribosomal protein S28, mitochondrial"
FT /id="PRO_0000087715"
FT REGION 29..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 72
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 132
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y2Q9"
FT CONFLICT 60
FT /note="S -> L (in Ref. 1; AAH28530)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 186 AA; 20520 MW; 74EFA7A6611823B4 CRC64;
MAALCRSHAG TAGSRFLRAL VFSKPLRNAS TESGSESATH DSSAPRARSG GFASALERHS
DLQRKAELRL ESPKPVESFA SMLRHSPLTQ LGPAKDKLVI GRIFHIVEDD LYIDFGGKFH
CVCKRPDVDG EKYQRGTRVR LRLLDLELTS RFLGGTTDTT ILEADAVLLG LQEIRDSKSR
EEQPSK
