RT31_MOUSE
ID RT31_MOUSE Reviewed; 384 AA.
AC Q61733; Q3TSP5; Q8VEH4; Q9D045;
DT 19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=28S ribosomal protein S31, mitochondrial;
DE Short=MRP-S31;
DE Short=S31mt;
DE AltName: Full=Imogen 38;
DE Flags: Precursor;
GN Name=Mrps31; Synonyms=Imogn38;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Pancreatic islet;
RX PubMed=8567980; DOI=10.1172/jci118448;
RA Arden S.D., Roep B.O., Neophytou P.I., Usac E.F., Duinkerken G.,
RA de Vries R.R.P., Hutton J.C.;
RT "Imogen 38: a novel 38-kD islet mitochondrial autoantigen recognized by T
RT cells from a newly diagnosed type 1 diabetic patient.";
RL J. Clin. Invest. 97:551-561(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Embryo, and Medulla oblongata;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland, and Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Component of the mitochondrial ribosome small subunit (28S)
CC which comprises a 12S rRNA and about 30 distinct proteins.
CC {ECO:0000250|UniProtKB:P82925}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P82925}.
CC -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC mS31 family. {ECO:0000305}.
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DR EMBL; Z46966; CAA87087.1; -; mRNA.
DR EMBL; AK005110; BAB23825.1; -; mRNA.
DR EMBL; AK011825; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK161913; BAE36630.1; -; mRNA.
DR EMBL; BC018475; AAH18475.1; -; mRNA.
DR EMBL; BC027430; AAH27430.1; -; mRNA.
DR CCDS; CCDS22176.1; -.
DR RefSeq; NP_065585.1; NM_020560.2.
DR AlphaFoldDB; Q61733; -.
DR SMR; Q61733; -.
DR BioGRID; 208251; 13.
DR ComplexPortal; CPX-5301; 28S mitochondrial small ribosomal subunit.
DR IntAct; Q61733; 2.
DR MINT; Q61733; -.
DR STRING; 10090.ENSMUSP00000033934; -.
DR iPTMnet; Q61733; -.
DR PhosphoSitePlus; Q61733; -.
DR EPD; Q61733; -.
DR MaxQB; Q61733; -.
DR PaxDb; Q61733; -.
DR PeptideAtlas; Q61733; -.
DR PRIDE; Q61733; -.
DR ProteomicsDB; 260862; -.
DR Antibodypedia; 23335; 166 antibodies from 26 providers.
DR DNASU; 57312; -.
DR Ensembl; ENSMUST00000033934; ENSMUSP00000033934; ENSMUSG00000031533.
DR GeneID; 57312; -.
DR KEGG; mmu:57312; -.
DR UCSC; uc009ldb.2; mouse.
DR CTD; 10240; -.
DR MGI; MGI:1913153; Mrps31.
DR VEuPathDB; HostDB:ENSMUSG00000031533; -.
DR eggNOG; ENOG502QSX9; Eukaryota.
DR GeneTree; ENSGT00390000010017; -.
DR HOGENOM; CLU_052666_0_0_1; -.
DR InParanoid; Q61733; -.
DR OMA; FDEGYDN; -.
DR OrthoDB; 1584591at2759; -.
DR PhylomeDB; Q61733; -.
DR TreeFam; TF324305; -.
DR Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 57312; 10 hits in 72 CRISPR screens.
DR ChiTaRS; Mrps31; mouse.
DR PRO; PR:Q61733; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q61733; protein.
DR Bgee; ENSMUSG00000031533; Expressed in ileal epithelium and 265 other tissues.
DR Genevisible; Q61733; MM.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR GO; GO:0005763; C:mitochondrial small ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IDA:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0019904; F:protein domain specific binding; ISO:MGI.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR InterPro; IPR026299; MRP-S31.
DR PANTHER; PTHR13231; PTHR13231; 1.
DR Pfam; PF15433; MRP-S31; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW Transit peptide.
FT TRANSIT 1..54
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 55..384
FT /note="28S ribosomal protein S31, mitochondrial"
FT /id="PRO_0000030595"
FT REGION 101..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 34
FT /note="A -> V (in Ref. 3; AAH18475)"
FT /evidence="ECO:0000305"
FT CONFLICT 95
FT /note="M -> I (in Ref. 3; AAH18475)"
FT /evidence="ECO:0000305"
FT CONFLICT 250..252
FT /note="DKA -> VKE (in Ref. 3; AAH18475)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 384 AA; 43881 MW; A7D594D131A024E6 CRC64;
MLHRIPAFLR PRPFSGLPLS CGNRDVSVAV LPAAQSGAVR TENNIQRHFC TSRSICSKKV
DQSVPANEIS QKAAESQGRG KETLKKDLLD IIKDMKVDLS TANVKTPKPR GRKPSASLEA
TVDRLQKAPE DPPKKRNEFL SPELVAAASA VADSLPFDKQ TTKSELLRQL QQHEEELRAQ
KDREKRRISF THIISNMKIA KSPSGRASTR PQHQIQFDED MDSSLKQEKP TDFRKRKYLF
KGKRLSIFAD KAFADEPPEP EASPSLWEIE FAKQLASVAD QPFENGFEEM IQWTKEGKLW
EFPVNNEAGL DDDGSEFHEH IFLDKYLEDF PKQGPIRLFM ELVTCGLSKN PYLSVKQKVE
HIEWFRNYFN EKRDILKENN IAFT
