ID   RT4I1_BOVIN             Reviewed;         396 AA.
AC   Q0VC50;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Reticulon-4-interacting protein 1, mitochondrial;
DE   Flags: Precursor;
GN   Name=RTN4IP1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in the regulation of retinal ganglion cell (RGC)
CC       neurite outgrowth, and hence in the development of the inner retina and
CC       optic nerve. Appears to be a potent inhibitor of regeneration following
CC       spinal cord injury. {ECO:0000250|UniProtKB:Q924D0}.
CC   -!- SUBUNIT: Interacts with RTN4, UQCRC1 and UQCRC2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC       {ECO:0000250|UniProtKB:Q8WWV3}. Note=Colocalizes with the endoplasmic
CC       reticulum HSPA5 at spots corresponding to contacts with mitochondria.
CC       {ECO:0000250|UniProtKB:Q8WWV3}.
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. Quinone oxidoreductase subfamily. {ECO:0000305}.
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DR   EMBL; BC120354; AAI20355.1; -; mRNA.
DR   RefSeq; NP_001068743.1; NM_001075275.1.
DR   RefSeq; XP_005210889.1; XM_005210832.3.
DR   RefSeq; XP_005210890.1; XM_005210833.3.
DR   RefSeq; XP_010806762.1; XM_010808460.2.
DR   AlphaFoldDB; Q0VC50; -.
DR   SMR; Q0VC50; -.
DR   STRING; 9913.ENSBTAP00000023334; -.
DR   PaxDb; Q0VC50; -.
DR   PRIDE; Q0VC50; -.
DR   Ensembl; ENSBTAT00000075533; ENSBTAP00000059531; ENSBTAG00000017554.
DR   Ensembl; ENSBTAT00000080271; ENSBTAP00000067725; ENSBTAG00000017554.
DR   GeneID; 506626; -.
DR   KEGG; bta:506626; -.
DR   CTD; 84816; -.
DR   VEuPathDB; HostDB:ENSBTAG00000017554; -.
DR   VGNC; VGNC:34205; RTN4IP1.
DR   eggNOG; KOG1198; Eukaryota.
DR   GeneTree; ENSGT00880000138028; -.
DR   HOGENOM; CLU_026673_3_3_1; -.
DR   InParanoid; Q0VC50; -.
DR   OMA; TSWQALK; -.
DR   OrthoDB; 727365at2759; -.
DR   TreeFam; TF313919; -.
DR   Proteomes; UP000009136; Chromosome 9.
DR   Bgee; ENSBTAG00000017554; Expressed in oocyte and 105 other tissues.
DR   ExpressionAtlas; Q0VC50; baseline and differential.
DR   GO; GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0050773; P:regulation of dendrite development; ISS:UniProtKB.
DR   CDD; cd08248; RTN4I1; 1.
DR   InterPro; IPR013154; ADH_N.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR   InterPro; IPR037397; RTN4I1.
DR   Pfam; PF08240; ADH_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; SSF50129; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Neurogenesis;
KW   Reference proteome; Transit peptide.
FT   TRANSIT         1..40
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           41..396
FT                   /note="Reticulon-4-interacting protein 1, mitochondrial"
FT                   /id="PRO_0000327931"
SQ   SEQUENCE   396 AA;  43583 MW;  339868294B042D4D CRC64;
     MGFLKTCVFR RNACTAVCFW RSQVVQKPSV RKISTTSPRS TVMPAWVIDK YGSNEVLRFT
     QNMMIPMIHY PNEVIIKVHA ASINPIDVNM RSGYGATALN MKRDPLHVKI KGEEFPLTLG
     RDVSGVVMEC GLDVRYFKPG DEVWAAVPPW KQGTLSEFVV VSGNEVSHKP RSLTHTQAAS
     LPYVALTAWS AINKVGGLND RNCTGKRVLI LGASGGVGTF AIQVMKAWDA HVTAVCSQDA
     SELVRKLGAD DVIDYKSGNV EAQLKSSKPF DFILDNVGGS TETWALKFLK KWSGATYVTL
     VTPFLLNMDR LGIADGMLQT GVTVGSKTLK HFWQGVHYRW AFFMASGPCL DDIAELVEAG
     KIQPVIEKTF PFSKVPEAFL KVERGHARGK TVINVV