ID   RT63_MOUSE              Reviewed;         102 AA.
AC   Q9CQF8;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Ribosomal protein 63, mitochondrial;
DE   AltName: Full=Mitochondrial ribosomal protein 63;
DE   AltName: Full=Mitochondrial ribosomal protein L57;
DE   AltName: Full=mMRP63;
GN   Name=Mrpl57; Synonyms=Mrp63;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11402041; DOI=10.1074/jbc.m103236200;
RA   Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A.,
RA   Watanabe K.;
RT   "Proteomic analysis of the mammalian mitochondrial ribosome. Identification
RT   of protein components in the 28S small subunit.";
RL   J. Biol. Chem. 276:33181-33195(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Embryo, and Heart;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Heart, Kidney, Liver, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- MISCELLANEOUS: Identified only in the intact 55S subunit. It is unknown
CC       whether it belongs to the 28S or to the 39S subunit. May localize at
CC       the subunit interface and dissociate from the 55S mitoribosome during
CC       subunit separation.
CC   -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC       mL63 family. {ECO:0000305}.
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DR   EMBL; AK003130; BAB22590.1; -; mRNA.
DR   EMBL; AK010282; BAB26818.1; -; mRNA.
DR   EMBL; AK011558; BAB27696.1; -; mRNA.
DR   EMBL; AB049958; BAB41011.1; -; mRNA.
DR   EMBL; BC049555; AAH49555.1; -; mRNA.
DR   EMBL; BC055723; AAH55723.1; -; mRNA.
DR   CCDS; CCDS27161.1; -.
DR   RefSeq; NP_080677.1; NM_026401.2.
DR   RefSeq; XP_006519541.1; XM_006519478.1.
DR   AlphaFoldDB; Q9CQF8; -.
DR   SMR; Q9CQF8; -.
DR   ComplexPortal; CPX-5302; 39S mitochondrial large ribosomal subunit.
DR   STRING; 10090.ENSMUSP00000022538; -.
DR   PhosphoSitePlus; Q9CQF8; -.
DR   EPD; Q9CQF8; -.
DR   MaxQB; Q9CQF8; -.
DR   PaxDb; Q9CQF8; -.
DR   PeptideAtlas; Q9CQF8; -.
DR   PRIDE; Q9CQF8; -.
DR   ProteomicsDB; 262723; -.
DR   Antibodypedia; 49702; 19 antibodies from 7 providers.
DR   DNASU; 67840; -.
DR   Ensembl; ENSMUST00000022538; ENSMUSP00000022538; ENSMUSG00000021967.
DR   GeneID; 67840; -.
DR   KEGG; mmu:67840; -.
DR   UCSC; uc007udq.1; mouse.
DR   CTD; 78988; -.
DR   MGI; MGI:1915090; Mrpl57.
DR   VEuPathDB; HostDB:ENSMUSG00000021967; -.
DR   eggNOG; ENOG502S44A; Eukaryota.
DR   GeneTree; ENSGT00390000008171; -.
DR   HOGENOM; CLU_175792_1_0_1; -.
DR   InParanoid; Q9CQF8; -.
DR   OMA; QEFGHAA; -.
DR   OrthoDB; 1622855at2759; -.
DR   PhylomeDB; Q9CQF8; -.
DR   TreeFam; TF324466; -.
DR   Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR   Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR   BioGRID-ORCS; 67840; 26 hits in 74 CRISPR screens.
DR   ChiTaRS; Mrpl57; mouse.
DR   PRO; PR:Q9CQF8; -.
DR   Proteomes; UP000000589; Chromosome 14.
DR   RNAct; Q9CQF8; protein.
DR   Bgee; ENSMUSG00000021967; Expressed in bone fossa and 253 other tissues.
DR   Genevisible; Q9CQF8; MM.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR   GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISO:MGI.
DR   GO; GO:0005761; C:mitochondrial ribosome; IDA:MGI.
DR   GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR   GO; GO:0003735; F:structural constituent of ribosome; IDA:MGI.
DR   GO; GO:0032543; P:mitochondrial translation; ISS:UniProtKB.
DR   GO; GO:0006412; P:translation; IDA:MGI.
DR   InterPro; IPR016576; Ribosomal_MRP63_mit.
DR   PANTHER; PTHR14520; PTHR14520; 1.
DR   Pfam; PF14978; MRP-63; 1.
DR   PIRSF; PIRSF011124; MRP63; 1.
PE   1: Evidence at protein level;
KW   Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT   CHAIN           1..102
FT                   /note="Ribosomal protein 63, mitochondrial"
FT                   /id="PRO_0000253542"
SQ   SEQUENCE   102 AA;  11952 MW;  918D9774AEA7C774 CRC64;
     MFLTAVLLRG RIPGRQWIGK HRRPRTVSFQ AKESMIRRLE VEAENHYWLS MPYMTAEQEC
     GHAAERRAQA FEAIKAAATS KFPKHRYIAD QLDHLNISKK WS