ID   RTA1_AJECA              Reviewed;         312 AA.
AC   B2KWI0;
DT   20-JUN-2018, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   25-MAY-2022, entry version 18.
DE   RecName: Full=Lipid-translocating exporter-like protein RTA1 {ECO:0000305|PubMed:18404210};
DE   AltName: Full=Siderophore biosynthesis cluster protein RTA1 {ECO:0000303|PubMed:18404210};
GN   Name=RTA1 {ECO:0000303|PubMed:18404210};
OS   Ajellomyces capsulatus (Darling's disease fungus) (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=5037;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND INDUCTION.
RC   STRAIN=ATCC 26032 / G217B;
RX   PubMed=18404210; DOI=10.1371/journal.ppat.1000044;
RA   Hwang L.H., Mayfield J.A., Rine J., Sil A.;
RT   "Histoplasma requires SID1, a member of an iron-regulated siderophore gene
RT   cluster, for host colonization.";
RL   PLoS Pathog. 4:E1000044-E1000044(2008).
CC   -!- FUNCTION: Lipid-translocating exporter-like protein; part of the gene
CC       cluster that mediates the biosynthesis of hydroxamate-containing
CC       siderophores that play a critical role in virulence via intracellular
CC       iron acquisition during macrophage infection (PubMed:18404210).
CC       {ECO:0000269|PubMed:18404210}.
CC   -!- PATHWAY: Siderophore biosynthesis. {ECO:0000305|PubMed:18404210}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- INDUCTION: Expression seems not to be induced during iron deprivation
CC       (PubMed:18404210). {ECO:0000269|PubMed:18404210}.
CC   -!- SIMILARITY: Belongs to the lipid-translocating exporter (LTE) (TC
CC       9.A.26.1) family. {ECO:0000305}.
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DR   EMBL; EU253975; ACC64453.1; -; Genomic_DNA.
DR   AlphaFoldDB; B2KWI0; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR007568; RTA1.
DR   PANTHER; PTHR31465; PTHR31465; 1.
DR   Pfam; PF04479; RTA1; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..312
FT                   /note="Lipid-translocating exporter-like protein RTA1"
FT                   /id="PRO_0000444419"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        223..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        258
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        304
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   312 AA;  34277 MW;  ADCC1F28B6530136 CRC64;
     MSPESKKITA HGSTSMPLSR TSKPQKFTIP LTVGAIFSVI GFLQRFFLAS GKGDVQSLYT
     LSTMFILGAG PTYAGADYFI CGRLFSFVPS AAPMSPIRVV RTFITFDVLA EVCVWTGAGL
     LAGAHTDTAA RYKIGLNLIR AAMITQAFLF TSFVAILASF HVRVCALRAE WSVTSNGGTG
     RRFMMVVHSL YASSIFIIIR SAYHIAGHSF RTNEQPFLIC EASLMLLNTA MFNVFHPGHI
     LPIDSRVYVG IDGQERANET IEGAFTDSRP LLQKILDPLD VKGLFSRDKK RWHDPTAELE
     MDINSTLYAA LT