ID   RTA1_LEPMJ              Reviewed;         521 AA.
AC   E5AE43;
DT   10-APR-2019, integrated into UniProtKB/Swiss-Prot.
DT   08-FEB-2011, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Lipid-translocating exporter-like protein RTA1 {ECO:0000303|PubMed:23396262};
DE   AltName: Full=Phomenoic acid biosynthesis cluster protein RTA1 {ECO:0000303|PubMed:23396262};
GN   Name=RTA1 {ECO:0000303|PubMed:23396262}; ORFNames=LEMA_P002690;
OS   Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8)
OS   (Blackleg fungus) (Phoma lingam).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Leptosphaeriaceae;
OC   Leptosphaeria; Leptosphaeria maculans species complex.
OX   NCBI_TaxID=985895;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8;
RX   PubMed=21326234; DOI=10.1038/ncomms1189;
RA   Rouxel T., Grandaubert J., Hane J.K., Hoede C., van de Wouw A.P.,
RA   Couloux A., Dominguez V., Anthouard V., Bally P., Bourras S.,
RA   Cozijnsen A.J., Ciuffetti L.M., Degrave A., Dilmaghani A., Duret L.,
RA   Fudal I., Goodwin S.B., Gout L., Glaser N., Linglin J., Kema G.H.J.,
RA   Lapalu N., Lawrence C.B., May K., Meyer M., Ollivier B., Poulain J.,
RA   Schoch C.L., Simon A., Spatafora J.W., Stachowiak A., Turgeon B.G.,
RA   Tyler B.M., Vincent D., Weissenbach J., Amselem J., Quesneville H.,
RA   Oliver R.P., Wincker P., Balesdent M.-H., Howlett B.J.;
RT   "Effector diversification within compartments of the Leptosphaeria maculans
RT   genome affected by Repeat-Induced Point mutations.";
RL   Nat. Commun. 2:202-202(2011).
RN   [2]
RP   IDENTIFICATION, FUNCTION, AND INDUCTION.
RX   PubMed=23396262; DOI=10.1016/j.fgb.2013.01.008;
RA   Elliott C.E., Callahan D.L., Schwenk D., Nett M., Hoffmeister D.,
RA   Howlett B.J.;
RT   "A gene cluster responsible for biosynthesis of phomenoic acid in the plant
RT   pathogenic fungus, Leptosphaeria maculans.";
RL   Fungal Genet. Biol. 53:50-58(2013).
CC   -!- FUNCTION: Lipid-translocating exporter-like protein; part of the gene
CC       cluster that mediates the biosynthesis of phomenoic acid, a long chain
CC       aliphatic carboxylic acid that does not appear to be essential for
CC       pathogenicity but may play a role in allowing to outcompete other fungi
CC       in the environmental niche via its antifungal properties.
CC       {ECO:0000269|PubMed:23396262}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- INDUCTION: Expression is positively regulated by the phomenoic acid
CC       biosynthesis cluster-specific transcription regulator C6TF.
CC       {ECO:0000269|PubMed:23396262}.
CC   -!- SIMILARITY: Belongs to the lipid-translocating exporter (LTE) (TC
CC       9.A.26.1) family. {ECO:0000305}.
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DR   EMBL; FP929139; CBY01482.1; -; Genomic_DNA.
DR   RefSeq; XP_003844961.1; XM_003844913.1.
DR   AlphaFoldDB; E5AE43; -.
DR   EnsemblFungi; CBY01482; CBY01482; LEMA_P002690.1.
DR   GeneID; 13290523; -.
DR   eggNOG; ENOG502RNSS; Eukaryota.
DR   HOGENOM; CLU_522814_0_0_1; -.
DR   InParanoid; E5AE43; -.
DR   OrthoDB; 889422at2759; -.
DR   Proteomes; UP000002668; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR007568; RTA1.
DR   PANTHER; PTHR31465; PTHR31465; 1.
DR   Pfam; PF04479; RTA1; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..521
FT                   /note="Lipid-translocating exporter-like protein RTA1"
FT                   /id="PRO_0000446535"
FT   TRANSMEM        186..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        249..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        292..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        332..352
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        371..391
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        418..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          493..521
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   521 AA;  58112 MW;  96C9A8877B232357 CRC64;
     MNAYAYTACL GIYGSTPNNE QLVLGSPDQL QRNKPRFRLI VLPHAPAASP FYPPWRSFAP
     DWEGQGARPM DHFKVGNLRF QLETHRIDEH STFGKLFGHA PSPSQSCVSF QKKSDRAEPL
     LLARCSAASW SCIHPPTVLY FVAYQLEYPF AARFSATKIS PIQDKMVATS DVPIVGSLYV
     YAPNKGAPIF FTIAFAISTI LHSWQCHRYK AWKLIWLQPA CAALFTLGYA LREYGAYNYL
     YDGTEKAPLA LFILSQICIY LGPPLLELAN YHILGRVFHY VPYAAPFNPG RVTAFFGGLM
     AIVEGLSGSG VSLTANAKAK ESTKKTGHNL LLVALALQVC VIFIFVYLSV LFHRRCIKAK
     VPAQSKAVKS TLMTLYLSMA LIFIRCVFRL VEMATSSTSV DITSMERLMK LSPVLRNEAY
     FYAFEASLML INSFLWNVQH PGPHLPGDTH IYLAQDGTEV EGEGDGSEDR PLLLNMANTL
     MFGLLYRDDK DHTHSQPQEL YENPNGNGHK KFRLGNGGRA T