ID   RTA_EBVB9               Reviewed;         605 AA.
AC   P03209; Q777E4;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   23-FEB-2022, entry version 97.
DE   RecName: Full=Replication and transcription activator;
DE            Short=Rta;
DE   AltName: Full=Immediate-early protein Rta;
GN   ORFNames=BRLF1;
OS   Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus.
OX   NCBI_TaxID=10377;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=6087149; DOI=10.1038/310207a0;
RA   Baer R., Bankier A.T., Biggin M.D., Deininger P.L., Farrell P.J.,
RA   Gibson T.J., Hatfull G., Hudson G.S., Satchwell S.C., Seguin C.,
RA   Tuffnell P.S., Barrell B.G.;
RT   "DNA sequence and expression of the B95-8 Epstein-Barr virus genome.";
RL   Nature 310:207-211(1984).
RN   [2]
RP   INTERACTION WITH HUMAN ATF7IP.
RX   PubMed=16314315; DOI=10.1093/nar/gki956;
RA   Chang L.-K., Chung J.-Y., Hong Y.-R., Ichimura T., Nakao M., Liu S.-T.;
RT   "Activation of Sp1-mediated transcription by Rta of Epstein-Barr virus via
RT   an interaction with MCAF1.";
RL   Nucleic Acids Res. 33:6528-6539(2005).
RN   [3]
RP   FUNCTION.
RX   PubMed=19098430; DOI=10.4161/cc.8.1.7411;
RA   Chen Y.L., Chen Y.J., Tsai W.H., Ko Y.C., Chen J.Y., Lin S.F.;
RT   "The Epstein-Barr virus replication and transcription activator, Rta/BRLF1,
RT   induces cellular senescence in epithelial cells.";
RL   Cell Cycle 8:58-65(2009).
RN   [4]
RP   FUNCTION.
RX   PubMed=17301127; DOI=10.1128/jvi.02448-06;
RA   Ho C.H., Hsu C.F., Fong P.F., Tai S.K., Hsieh S.L., Chen C.J.;
RT   "Epstein-Barr virus transcription activator Rta upregulates decoy receptor
RT   3 expression by binding to its promoter.";
RL   J. Virol. 81:4837-4847(2007).
RN   [5]
RP   REVIEW.
RX   PubMed=17089794; DOI=10.1007/978-3-540-34344-8_3;
RA   Staudt M.R., Dittmer D.P.;
RT   "The Rta/Orf50 transactivator proteins of the gamma-herpesviridae.";
RL   Curr. Top. Microbiol. Immunol. 312:71-100(2007).
CC   -!- FUNCTION: Immediate-early transcription factor that controls the
CC       initiation of viral lytic gene expression and lytic reactivation from
CC       latency. Triggers lytic replication, and initiates a cellular
CC       senescence program in epithelial cells. Up-regulates human
CC       DCR3/TNFRSF6B by directly binding to its receptor.
CC       {ECO:0000269|PubMed:17301127, ECO:0000269|PubMed:19098430}.
CC   -!- SUBUNIT: Interacts with human ATF7IP protein, leading to promote and
CC       regulate host genes in virus-infected cells.
CC       {ECO:0000269|PubMed:16314315}.
CC   -!- INTERACTION:
CC       P03209; Q3KSP5: LF2; Xeno; NbExp=2; IntAct=EBI-2621080, EBI-2621084;
CC   -!- SIMILARITY: Belongs to the herpesviridae Rta family. {ECO:0000305}.
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DR   EMBL; V01555; CAA24814.1; -; Genomic_DNA.
DR   EMBL; AJ507799; CAD53424.1; -; Genomic_DNA.
DR   PIR; A43043; QQBE29.
DR   RefSeq; YP_401674.1; NC_007605.1.
DR   BioGRID; 971769; 4.
DR   IntAct; P03209; 15.
DR   MINT; P03209; -.
DR   PRIDE; P03209; -.
DR   DNASU; 3783727; -.
DR   GeneID; 3783727; -.
DR   KEGG; vg:3783727; -.
DR   SIGNOR; P03209; -.
DR   Proteomes; UP000153037; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0050434; P:positive regulation of viral transcription; IDA:CACAO.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0019046; P:release from viral latency; IEA:UniProtKB-KW.
DR   InterPro; IPR004998; Herpes_TAF50.
DR   Pfam; PF03326; Herpes_TAF50; 2.
PE   1: Evidence at protein level;
KW   Activator; DNA-binding; Early protein; Host-virus interaction;
KW   Reference proteome; Transcription; Transcription regulation; Viral latency;
KW   Viral reactivation from latency.
FT   CHAIN           1..605
FT                   /note="Replication and transcription activator"
FT                   /id="PRO_0000116201"
FT   REGION          307..380
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          447..499
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        322..337
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        338..357
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        481..495
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   605 AA;  66595 MW;  B5B7DF0593FADB08 CRC64;
     MRPKKDGLED FLRLTPEIKK QLGSLVSDYC NVLNKEFTAG SVEITLRSYK ICKAFINEAK
     AHGREWGGLM ATLNICNFWA ILRNNRVRRR AENAGNDACS IACPIVMRYV LDHLIVVTDR
     FFIQAPSNRV MIPATIGTAM YKLLKHSRVR AYTYSKVLGV DRAAIMASGK QVVEHLNRME
     KEGLLSSKFK AFCKWVFTYP VLEEMFQTMV SSKTGHLTDD VKDVRALIKT LPRASYSSHA
     GQRSYVSGVL PACLLSTKSK AVETPILVSG ADRMDEELMG NDGGASHTEA RYSESGQFHA
     FTDELESLPS PTMPLKPGAQ SADCGDSSSS SSDSGNSDTE QSEREEARAE APRLRAPKSR
     RTSRPNRGQT PCPSNAAEPE QPWIAAVHQE SDERPIFPHP SKPTFLPPVK RKKGLRDSRE
     GMFLPKPEAG SAISDVFEGR EVCQPKRIRP FHPPGSPWAN RPLPASLAPT PTGPVHEPVG
     SLTPAPVPQP LDPAPAVTPE ASHLLEDPDE ETSQAVKALR EMADTVIPQK EEAAICGQMD
     LSHPPPRGHL DELTTTLESM TEDLNLDSPL TPELNEILDT FLNDECLLHA MHISTGLSIF
     DTSLF