ID   RTA_EBVG                Reviewed;         605 AA.
AC   Q3KSS7;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   23-FEB-2022, entry version 43.
DE   RecName: Full=Replication and transcription activator;
DE            Short=Rta;
DE   AltName: Full=Immediate-early protein Rta;
GN   ORFNames=BRLF1;
OS   Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus.
OX   NCBI_TaxID=10376;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16306603; DOI=10.1128/jvi.79.24.15323-15330.2005;
RA   Zeng M.-S., Li D.-J., Liu Q.-L., Song L.-B., Li M.-Z., Zhang R.-H.,
RA   Yu X.-J., Wang H.-M., Ernberg I., Zeng Y.-X.;
RT   "Genomic sequence analysis of Epstein-Barr virus strain GD1 from a
RT   nasopharyngeal carcinoma patient.";
RL   J. Virol. 79:15323-15330(2005).
CC   -!- FUNCTION: Immediate-early transcription factor that controls the
CC       initiation of viral lytic gene expression and lytic reactivation from
CC       latency. Triggers lytic replication, and initiates a cellular
CC       senescence program in epithelial cells. Up-regulates human
CC       DCR3/TNFRSF6B by directly binding to its receptor (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with human ATF7IP protein, leading to promote and
CC       regulate host genes in virus-infected cells. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the herpesviridae Rta family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY961628; AAY41122.1; -; Genomic_DNA.
DR   PDB; 6NCA; X-ray; 3.30 A; 1/2/3/4/5/6/7/8/U/V/W/X/Y/Z/u/v/w/x/y/z=109-117.
DR   PDBsum; 6NCA; -.
DR   SMR; Q3KSS7; -.
DR   IntAct; Q3KSS7; 5.
DR   MINT; Q3KSS7; -.
DR   PRIDE; Q3KSS7; -.
DR   Proteomes; UP000007641; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0019046; P:release from viral latency; IEA:UniProtKB-KW.
DR   InterPro; IPR004998; Herpes_TAF50.
DR   Pfam; PF03326; Herpes_TAF50; 2.
PE   1: Evidence at protein level;
KW   3D-structure; Activator; DNA-binding; Early protein;
KW   Host-virus interaction; Transcription; Transcription regulation;
KW   Viral latency; Viral reactivation from latency.
FT   CHAIN           1..605
FT                   /note="Replication and transcription activator"
FT                   /id="PRO_0000408272"
FT   REGION          307..381
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          447..501
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        322..337
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        338..357
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        481..495
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   605 AA;  66680 MW;  909499D0BAC653B1 CRC64;
     MRPKKDGLED FLRLTPEIKK QLGSLVSDYC NVLNKEFTAG SVEITLRSYK ICKAFINEAK
     AHGREWGGLM ATLNICNFWA ILRNNRVRRR AENAGNDACS IACPIVMRYV LDHLIVVTDR
     FFIQAPSNRV MIPATIGTAM YKLLKHSRVR AYTYSKVLGV DRAAIMASGK QVVEHLNRME
     KEGLLSSKFK AFCKWVFTYP VLEEMFQTMV SSKTGHLTDD VKDVRALIKT LPRASYSSHA
     GQRSYVSGVL PACLLSTKSK AVETPILVSG ADRMDEELMG NDGGASHTEA RYSESGQFHA
     FTDELESLPS PTMPLKPGAQ SADCGDSSSS SSDSGNSDTE QSEREEARAE APRLRAPKSR
     RTSRPNRGQT PCPSNAEEPE QPWIAAVHQE SDERPIFPHP SKPTFLPPVK RKKGLRDSRE
     GMFLPKPEAG SAISDVFEGR EVCQPKRIRP FHPPGSPWAN RPLPASLAPT PTGPVHEPVG
     SLTPAPVPKP LDPAPAVTPE ASHLLEDPDE ETSQAVKALR EMADTVIPQK EEAAICGQMD
     LNHPPPRGHL DELTTTLESM TEDLNLDSPL TPELNEILDT FLNDECLLHA MHISTGLSIF
     DTSLF