ID   RTBDN_CANLF             Reviewed;         223 AA.
AC   Q4TUC0;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Retbindin;
DE   Flags: Precursor;
GN   Name=RTBDN;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Retina;
RA   Wistow G.;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Riboflavin-binding protein which might have a role in retinal
CC       flavin transport. {ECO:0000250|UniProtKB:Q8QZY4}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix, interphotoreceptor matrix {ECO:0000250|UniProtKB:Q8QZY4}. Cell
CC       membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8QZY4}.
CC   -!- PTM: Not N-glycosylated. {ECO:0000250|UniProtKB:Q8QZY4}.
CC   -!- SIMILARITY: Belongs to the folate receptor family. {ECO:0000305}.
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DR   EMBL; DQ058011; AAY57282.1; -; mRNA.
DR   RefSeq; NP_001020132.1; NM_001024961.1.
DR   RefSeq; XP_005632379.1; XM_005632322.2.
DR   RefSeq; XP_005632380.1; XM_005632323.2.
DR   RefSeq; XP_013977209.1; XM_014121734.1.
DR   AlphaFoldDB; Q4TUC0; -.
DR   SMR; Q4TUC0; -.
DR   STRING; 9612.ENSCAFP00000025269; -.
DR   PaxDb; Q4TUC0; -.
DR   Ensembl; ENSCAFT00030035359; ENSCAFP00030030839; ENSCAFG00030019215.
DR   Ensembl; ENSCAFT00040044490; ENSCAFP00040038852; ENSCAFG00040023897.
DR   Ensembl; ENSCAFT00845028091; ENSCAFP00845022103; ENSCAFG00845015774.
DR   GeneID; 476698; -.
DR   KEGG; cfa:476698; -.
DR   CTD; 83546; -.
DR   VEuPathDB; HostDB:ENSCAFG00845015774; -.
DR   eggNOG; ENOG502RYYP; Eukaryota.
DR   GeneTree; ENSGT00950000183144; -.
DR   HOGENOM; CLU_081745_0_0_1; -.
DR   InParanoid; Q4TUC0; -.
DR   OrthoDB; 1534387at2759; -.
DR   Proteomes; UP000002254; Chromosome 20.
DR   Bgee; ENSCAFG00000017154; Expressed in jejunum and 6 other tissues.
DR   GO; GO:0031362; C:anchored component of external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0033165; C:interphotoreceptor matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:1902444; F:riboflavin binding; IBA:GO_Central.
DR   GO; GO:0032217; F:riboflavin transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR   InterPro; IPR004269; Folate_rcpt.
DR   InterPro; IPR018143; Folate_rcpt-like.
DR   PANTHER; PTHR10517; PTHR10517; 1.
DR   Pfam; PF03024; Folate_rec; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; Extracellular matrix; Membrane;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..223
FT                   /note="Retbindin"
FT                   /id="PRO_0000043173"
FT   DISULFID        73..143
FT                   /evidence="ECO:0000250|UniProtKB:P15328"
FT   DISULFID        80..120
FT                   /evidence="ECO:0000250|UniProtKB:P15328"
FT   DISULFID        113..157
FT                   /evidence="ECO:0000250|UniProtKB:P15328"
FT   DISULFID        126..139
FT                   /evidence="ECO:0000250|UniProtKB:P15328"
SQ   SEQUENCE   223 AA;  23859 MW;  A182BE692735F2EF CRC64;
     MANRGHTQPR ALAWALGLTL VWILLGACGG SRPLPALSRR HHRLAADLGT GQLHLAEMDT
     PEASGPGMVS EHCGKPSPGC ESFLGHLQVA LHNRFRLLLL GIRQAQPLCS ELCDIWFATC
     ESDITCGPTW LPLLEKRGCE PRCTTYEQTF ADGADLCRSV LGYALPVAAP GADHCLNISI
     SVLPGSRQER KAQEVTFPRS RRSRTWILDA PGSGSGSGSG SGP