RTBDN_MOUSE
ID RTBDN_MOUSE Reviewed; 247 AA.
AC Q8QZY4; Q6T898;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Retbindin;
DE Flags: Precursor;
GN Name=Rtbdn;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Eye;
RA Phelps M.A., Swaan P.W.;
RT "Characterization of mouse retbindin.";
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye;
RA Wistow G., Wyatt K.;
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND LACK OF
RP GLYCOSYLATION.
RX PubMed=25542898; DOI=10.1074/jbc.m114.624189;
RA Kelley R.A., Al-Ubaidi M.R., Naash M.I.;
RT "Retbindin is an extracellular riboflavin-binding protein found at the
RT photoreceptor/retinal pigment epithelium interface.";
RL J. Biol. Chem. 290:5041-5052(2015).
CC -!- FUNCTION: Riboflavin-binding protein which might have a role in retinal
CC flavin transport. {ECO:0000269|PubMed:25542898}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix, interphotoreceptor matrix {ECO:0000269|PubMed:25542898}. Cell
CC membrane {ECO:0000269|PubMed:25542898}; Peripheral membrane protein
CC {ECO:0000269|PubMed:25542898}.
CC -!- TISSUE SPECIFICITY: Expressed in the peripheral retina where it
CC localizes to the inter-photoreceptor matrix (at protein level). May be
CC produced by rod photoreceptors (at protein level).
CC {ECO:0000269|PubMed:25542898}.
CC -!- PTM: Not N-glycosylated. {ECO:0000269|PubMed:25542898}.
CC -!- SIMILARITY: Belongs to the folate receptor family. {ECO:0000305}.
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DR EMBL; AY428631; AAR87849.1; -; mRNA.
DR EMBL; AY527275; AAS20324.1; -; mRNA.
DR EMBL; AY527276; AAS20325.1; -; mRNA.
DR EMBL; BC022744; AAH22744.1; -; mRNA.
DR EMBL; BC023051; AAH23051.1; -; mRNA.
DR EMBL; BC027079; AAH27079.1; -; mRNA.
DR CCDS; CCDS22485.1; -.
DR RefSeq; NP_659178.1; NM_144929.2.
DR RefSeq; XP_006530928.1; XM_006530865.3.
DR AlphaFoldDB; Q8QZY4; -.
DR SMR; Q8QZY4; -.
DR STRING; 10090.ENSMUSP00000070558; -.
DR PhosphoSitePlus; Q8QZY4; -.
DR PaxDb; Q8QZY4; -.
DR PRIDE; Q8QZY4; -.
DR Antibodypedia; 65265; 53 antibodies from 14 providers.
DR DNASU; 234542; -.
DR Ensembl; ENSMUST00000067472; ENSMUSP00000070558; ENSMUSG00000048617.
DR Ensembl; ENSMUST00000109740; ENSMUSP00000105362; ENSMUSG00000048617.
DR Ensembl; ENSMUST00000121880; ENSMUSP00000113982; ENSMUSG00000048617.
DR GeneID; 234542; -.
DR KEGG; mmu:234542; -.
DR UCSC; uc009mog.1; mouse.
DR CTD; 83546; -.
DR MGI; MGI:2443686; Rtbdn.
DR VEuPathDB; HostDB:ENSMUSG00000048617; -.
DR eggNOG; ENOG502RYYP; Eukaryota.
DR GeneTree; ENSGT00950000183144; -.
DR HOGENOM; CLU_081745_0_0_1; -.
DR InParanoid; Q8QZY4; -.
DR OMA; MACRGHT; -.
DR OrthoDB; 1534387at2759; -.
DR PhylomeDB; Q8QZY4; -.
DR TreeFam; TF337710; -.
DR BioGRID-ORCS; 234542; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Rtbdn; mouse.
DR PRO; PR:Q8QZY4; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8QZY4; protein.
DR Bgee; ENSMUSG00000048617; Expressed in retinal neural layer and 39 other tissues.
DR ExpressionAtlas; Q8QZY4; baseline and differential.
DR Genevisible; Q8QZY4; MM.
DR GO; GO:0031362; C:anchored component of external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0019897; C:extrinsic component of plasma membrane; IDA:UniProtKB.
DR GO; GO:0033165; C:interphotoreceptor matrix; IDA:UniProtKB.
DR GO; GO:1902444; F:riboflavin binding; IDA:UniProtKB.
DR GO; GO:0032217; F:riboflavin transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR InterPro; IPR004269; Folate_rcpt.
DR InterPro; IPR018143; Folate_rcpt-like.
DR PANTHER; PTHR10517; PTHR10517; 1.
DR Pfam; PF03024; Folate_rec; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; Extracellular matrix; Membrane;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..31
FT /evidence="ECO:0000255"
FT CHAIN 32..247
FT /note="Retbindin"
FT /id="PRO_0000043175"
FT DISULFID 99..169
FT /evidence="ECO:0000250|UniProtKB:P15328"
FT DISULFID 106..146
FT /evidence="ECO:0000250|UniProtKB:P15328"
FT DISULFID 139..183
FT /evidence="ECO:0000250|UniProtKB:P15328"
FT DISULFID 152..165
FT /evidence="ECO:0000250|UniProtKB:P15328"
FT CONFLICT 82
FT /note="V -> E (in Ref. 1; AAR87849)"
FT /evidence="ECO:0000305"
FT CONFLICT 186
FT /note="V -> A (in Ref. 1; AAR87849)"
FT /evidence="ECO:0000305"
FT CONFLICT 209
FT /note="P -> T (in Ref. 1; AAR87849)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 247 AA; 26559 MW; 888DB7451A81D8E1 CRC64;
MAHEGHSQHS GLVWALRPIL AWIFLVACGW SHPLQTRSWG HPGLAAKVRT GQLQPAGHPQ
SSVLPSYPRI QVPGSQTPPV PVPCCTAEID RPESLLESCG APSPECEFFL GQLQGALRDR
FHPQLFGARP VQPLCPELCQ IWFTTCQADF ICGPTWLQSS GERGCEPSCR TYGQTFANAT
DLCHSVLGHV LRVAAPGSSH CLNVSISSPG ARRRPRAWIS NVVGSGSGSG SGDSPEPMFG
FQYVSLP
