RTC1_ASHGO
ID RTC1_ASHGO Reviewed; 1361 AA.
AC Q75AV6;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 2.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Restriction of telomere capping protein 1;
GN Name=RTC1; OrderedLocusNames=ADL186C;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: May be involved in a process influencing telomere capping.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Vacuole {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat RTC1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE016817; AAS51734.2; -; Genomic_DNA.
DR RefSeq; NP_983910.2; NM_209263.2.
DR AlphaFoldDB; Q75AV6; -.
DR STRING; 33169.AAS51734; -.
DR EnsemblFungi; AAS51734; AAS51734; AGOS_ADL186C.
DR GeneID; 4620052; -.
DR KEGG; ago:AGOS_ADL186C; -.
DR eggNOG; KOG0269; Eukaryota.
DR HOGENOM; CLU_008512_0_0_1; -.
DR InParanoid; Q75AV6; -.
DR OMA; GGRDGKC; -.
DR Proteomes; UP000000591; Chromosome IV.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0061700; C:GATOR2 complex; IBA:GO_Central.
DR GO; GO:0005774; C:vacuolar membrane; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0034198; P:cellular response to amino acid starvation; IBA:GO_Central.
DR GO; GO:0016239; P:positive regulation of macroautophagy; IBA:GO_Central.
DR GO; GO:1904263; P:positive regulation of TORC1 signaling; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR037590; WDR24.
DR InterPro; IPR001841; Znf_RING.
DR PANTHER; PTHR46200; PTHR46200; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding; Reference proteome; Repeat; Vacuole; WD repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..1361
FT /note="Restriction of telomere capping protein 1"
FT /id="PRO_0000408776"
FT REPEAT 180..221
FT /note="WD 1"
FT REPEAT 229..269
FT /note="WD 2"
FT REPEAT 277..315
FT /note="WD 3"
FT REPEAT 337..376
FT /note="WD 4"
FT REPEAT 405..452
FT /note="WD 5"
FT REPEAT 455..493
FT /note="WD 6"
FT REPEAT 849..890
FT /note="WD 7"
FT REPEAT 1146..1192
FT /note="WD 8"
FT REPEAT 1240..1278
FT /note="WD 9"
FT ZN_FING 1314..1356
FT /note="RING-type; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 1..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 564..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 896..916
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 953..982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1091..1113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..74
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..102
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..593
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 958..982
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1361 AA; 150385 MW; D6248E4EEEFBB62E CRC64;
MGARRESGLH SFLNRKTPPT ADMQQGSGGT RPQPFSRFTY GSKSAQSSGG MGGQVACSPK
GRGSQRSLLS SNFPFMESVF EDRTAAPQRT PTPRDERSEY FGEAEGSSGL RSSLQCNREL
ASLDKINDAQ ARMVVVAGKS HLGLYKFDEA YRMQQVHDYM TPGSLGGGTK FSSSMRRNMR
KISTISDVKA GFHHHKNYIA ICGTSTSVSI YDINRASAKD SPLITTLSEH SRSINSVDFN
MGQTHLLISG GQDGCIKVWD LRSHSYKVNR SDLNFNSGSD SVRDVKWMPT YDFASLGADT
SLCSSGRSNK FASVHDSGLL LTFDMRQPNQ VERKINAHSG PGLCMHWHPH MDYIISGGRD
GKCALWYVGD KVNSMVSVPQ GHNSATSYSI NTAPITTGYL ETVINTSHPV SKLKFRPKYV
HNMLNSLIAT SSMGEDSDVT IYSLARKHIP QNILTTAAPS LGFVWWNEDI VFNIDKQSVI
SAWDIRYEPT LLDNLPKGIV KWRDMDGSGL VFVAQEKGTY SMDNGGVTDS VGKGAANRMS
NTTLNSTNNM GRDQEVFTYS FQQQYKHQDQ EAADRESDHD KELEKERETE VDQHYHYLRE
QEREHHQEYQ EWEHEPFGRH DDHQGNPQTD FYSHAYSDRP MLSKALSTYS SKIASPILSY
YGAQTLSHHT SIVSNSPSIS GAALEYPGGI ESPIMITLDL PQVFGSVRAS RLADRKTSKN
KGNAPAVRES AVDIFKYLVR ELELCHVQER NDPKSISVDD RSKSLDDTEL KIQLMENIGL
SEHNTWATLI RSTTSMDTND PAGSHTQGHS KLVDMVKLQG SNILSPDNSD MEDDLGDKLD
EMGTARLQEN VNHLVGLIFL STHNAETYAS VNDLQNFKIW MLIRDSLLND LKEAADGSTG
RRDASGGAAN SDKNGIYTTT STVNHARQDS ITSNFSSFEP SDISRSDGEE KLNLGRLSEQ
NLKATNQNTT AKLDDTRKLA SSSSLNSSEP LLLLEGGNQA KEQSIGLSDL KTCLKERYTA
SNESVLDIEE ESSATVAYSS KQANTECSSS IPIRKTEART SFIDTIMTNL RSPGLSHLDV
DNDAIFGKGK TSTSLGSGAS KRSSMHSTDS YHKRPYSSPI TYSKITTAAQ KAKLGLADHD
GLPNRGSISF LANIDAAHAD KLLLGKLGLA SSPDDGKLLP PWDTGRLIQQ LYRYSVETGN
IILTVCIILL FQTMYKVTST RIVKSTLAEF ITILHRYEMF EISAHLLKNC PWDDILGAGS
GQSTVRLFCE NCGKLIVNEH SKTILSKRHQ AGESNMTNFG YWYCDSCRKP NSLCVYCEQP
MKKLALSFLN CGHGGHFECL QQWFLDEGMS ECPSGCSGVL L
