RTC1_CANAL
ID RTC1_CANAL Reviewed; 1088 AA.
AC Q5ACL4; A0A1D8PU94;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Restriction of telomere capping protein 1;
GN Name=RTC1; OrderedLocusNames=CAALFM_CR10510WA; ORFNames=CaO19.7629;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: May be involved in a process influencing telomere capping.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Vacuole {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat RTC1 family. {ECO:0000305}.
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DR EMBL; CP017630; AOW31700.1; -; Genomic_DNA.
DR RefSeq; XP_719389.1; XM_714296.1.
DR AlphaFoldDB; Q5ACL4; -.
DR SMR; Q5ACL4; -.
DR STRING; 237561.Q5ACL4; -.
DR PRIDE; Q5ACL4; -.
DR GeneID; 3639039; -.
DR KEGG; cal:CAALFM_CR10510WA; -.
DR CGD; CAL0000194538; orf19.7629.
DR VEuPathDB; FungiDB:CR_10510W_A; -.
DR eggNOG; KOG0269; Eukaryota.
DR HOGENOM; CLU_008512_0_0_1; -.
DR InParanoid; Q5ACL4; -.
DR OMA; GGRDGKC; -.
DR OrthoDB; 590848at2759; -.
DR Proteomes; UP000000559; Chromosome R.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0061700; C:GATOR2 complex; IBA:GO_Central.
DR GO; GO:0005774; C:vacuolar membrane; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0034198; P:cellular response to amino acid starvation; IBA:GO_Central.
DR GO; GO:0016239; P:positive regulation of macroautophagy; IBA:GO_Central.
DR GO; GO:1904263; P:positive regulation of TORC1 signaling; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR037590; WDR24.
DR InterPro; IPR001841; Znf_RING.
DR PANTHER; PTHR46200; PTHR46200; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding; Reference proteome; Repeat; Vacuole; WD repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..1088
FT /note="Restriction of telomere capping protein 1"
FT /id="PRO_0000408777"
FT REPEAT 131..170
FT /note="WD 1"
FT REPEAT 176..215
FT /note="WD 2"
FT REPEAT 222..266
FT /note="WD 3"
FT REPEAT 275..314
FT /note="WD 4"
FT REPEAT 367..417
FT /note="WD 5"
FT REPEAT 432..473
FT /note="WD 6"
FT REPEAT 502..546
FT /note="WD 7"
FT REPEAT 631..671
FT /note="WD 8"
FT ZN_FING 1040..1083
FT /note="RING-type; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 26..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 537..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 709..751
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 764..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 844..871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 709..731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 769..795
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 815..829
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1088 AA; 120975 MW; 4187B3E27DA916FB CRC64;
MSQSNSHGQS NLAKFAFNIY GTLSTNSSTP QSHEISPSSS LSSSRSKKQT SQYNTQDTNN
NRLSYYCDKE IISLSQLNCS LSIGGYSGDL QHHVVIGGKN YLRLLCVSES QQRIISGINL
LESKSIYNSR APNKLINVNT IKTFADTIAT GLSNGVVSIY KISPNGQSKV TGKYSDHNRT
INSLDFIESE NQLLSGSQDG TIKLWDLRSS STKPVMTVQA NLHSDPIRAC QYSPHSAVRN
KICVLSVHDS GALCKFDLRT KSGGKVYSPE KKWNLHTGPA LSLHIHPEKE LVVTGGRDKR
ISIFNYGERQ SRNTPQNLIN TYGPVVKVRW STYTNTEETA EEFEENKQAK PNTLYNYDIA
CSYLNDDPTI TIYNLGRKFI PKQIIHSKKP IQNFIWARNE TRSRKIWTIS KSSTFSSYNL
DRLEDSDVSR PIEDLNNIAM TWDNNNDFCA VSQARYDYDL ETYENGINET TEENFDAERN
YSLGNEELIH SQANSLTASP VDKPQLTRSL TFNPASSFST FSPVLVARAA TGFLQNDSAT
SSSSIPNMQV SSSRPKLTRN TSQTTQDSSS SQFASVLPPP SASQTYSSPQ YKKNNPPRFM
NNPAYVIPVS IPIPANDEYV FRKLSSESLV STPDGFTLVD VCLLNASVAA SVGNNRTSQI
WRLLAVSIQE EFESGIEPRR IYAFQPEAIN KLPQDVQETS TNANDTLHAE TTNSNFVESF
KSTSTSGSQF GKQSDKDERK LQSKNSSGNL MDMINKANRT NSFSATSFKF KEQERKEDES
QKAQSIKDEN ERASIHSKSA PISISSHPED LDDENMGSNN SAALKFSPPS VGVSIPSTRI
ISSSLASSPK SVRGPSGVKS HISRSRPSPP VQTWLKQKNL EVSNGSAMAS TSGLSLTLKR
NKTNEEGDQL TKAWKFKSLL RKSLDYATLQ GDIIFCSTAA LLFYDIVPEI ISQFECLEWL
GIYIEVLQRK RLFVNAINVI KCATADIQEK LQKLYCQDLS LRFYCSNCQA LLVNEKSKFS
GKGEFGYWYC DECSKLQSQC VYCNEPCKGL AVTVGLKCGH HGHFGCLKEW FIEDQNTECP
GGCGYQII
