RTC1_CANGA
ID RTC1_CANGA Reviewed; 1336 AA.
AC Q6FVJ1;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 123.
DE RecName: Full=Restriction of telomere capping protein 1;
GN Name=RTC1; OrderedLocusNames=CAGL0E01485g;
OS Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS Y-65) (Yeast) (Torulopsis glabrata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC Nakaseomyces/Candida clade.
OX NCBI_TaxID=284593;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: May be involved in a process influencing telomere capping.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Vacuole {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat RTC1 family. {ECO:0000305}.
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DR EMBL; CR380951; CAG58672.1; -; Genomic_DNA.
DR RefSeq; XP_445753.1; XM_445753.1.
DR AlphaFoldDB; Q6FVJ1; -.
DR STRING; 5478.XP_445753.1; -.
DR EnsemblFungi; CAG58672; CAG58672; CAGL0E01485g.
DR GeneID; 2887438; -.
DR KEGG; cgr:CAGL0E01485g; -.
DR CGD; CAL0128954; CAGL0E01485g.
DR VEuPathDB; FungiDB:CAGL0E01485g; -.
DR eggNOG; KOG0269; Eukaryota.
DR HOGENOM; CLU_008512_0_0_1; -.
DR InParanoid; Q6FVJ1; -.
DR OMA; GGRDGKC; -.
DR Proteomes; UP000002428; Chromosome E.
DR GO; GO:0097042; C:extrinsic component of fungal-type vacuolar membrane; IEA:EnsemblFungi.
DR GO; GO:0035859; C:Seh1-associated complex; IEA:EnsemblFungi.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:1904263; P:positive regulation of TORC1 signaling; IEA:EnsemblFungi.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR037590; WDR24.
DR InterPro; IPR001841; Znf_RING.
DR PANTHER; PTHR46200; PTHR46200; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 2.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding; Reference proteome; Repeat; Vacuole; WD repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..1336
FT /note="Restriction of telomere capping protein 1"
FT /id="PRO_0000408780"
FT REPEAT 233..274
FT /note="WD 1"
FT REPEAT 282..322
FT /note="WD 2"
FT REPEAT 331..372
FT /note="WD 3"
FT REPEAT 394..433
FT /note="WD 4"
FT REPEAT 472..519
FT /note="WD 5"
FT REPEAT 522..560
FT /note="WD 6"
FT REPEAT 864..905
FT /note="WD 7"
FT REPEAT 1135..1180
FT /note="WD 8"
FT REPEAT 1227..1266
FT /note="WD 9"
FT ZN_FING 1289..1331
FT /note="RING-type; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 107..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 941..973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1009..1054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1096..1115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1133..1167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1022..1041
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1336 AA; 148995 MW; 3D12FD06268CE716 CRC64;
MNFSPNKNMP AGSGGNGQDR VLHRTSSSAG KNAMKGVFSQ PHLSGANSST HMYIHDSAVR
PKLTAKYSYG STYAVGSQWY DFSSSNRGPS NSYGSSYEDK FIMGNANRRR TGTPYQGNQF
HGTHNHAHSH SQYSSSPHIS SSRSKSSQKS DAKKSTIKFH HRTNNEISSI DKVNDPSMQG
LICAGKTHLG YYKFSTVDNS MTCVHDFITS NNRNTPKGNS WILPNLSKRT KGAKISNIAD
VKCGFHNYSN VIAICNNSTD ISLYDLNRTT PAEDPMIQIL SGHTRAINSF DFNMSQTNLI
ISGGQDGCVK VWDIRSDSMK RQGRSDLNIK TANDSIRDVK WMPSHNFASL PSSADGKSLN
ISSPGYTFAS IHDTGVLLKY DLRQTTQVDK KINAHSGPGL CLNWHPHQDY IATGGRDGKC
SLWYVGDRRS TDQSPYSTTF LSSNATTNTS SIGIGYPGNP VASTFIPETT INTGSPITKL
KFRPNYDKIA LNSLIALSSM GDEAEVNIYS LARKYIPKHL LTTGKPSLGL VWWNSNLIFN
VDSAGYINGW DITNEPTVLD ELPKNIVRWR DVDGSGLLFL NQDTGSYEVS DQDELIDLHT
FQKQSSSTVK GDTATPGIGL MANIKRGLSH NNVSHFPTER PIPKRSAFSN ISKVPISSST
QSSVNKSSTS LSTLATQDEL LENKFLKSPL VIPFELPEAY QYSRESKIME LNKRSYIPKV
SSVRGSNIEV FKFLARELEF SFRQDKNNED DAELSRQQSV NEENIRSDLM KRFDISENAT
WANIVKDKSN KTRERANSIS IKQSPIVLSD ESEIKSPTIQ KLESGDNNVK YESNITKEIQ
QEKTKNFNPE YRINLLLELV ESSNHNASVY SIIDDLPNFK IWMLIRDSLL WDIKMYSSFS
ENETPEELTG GQLEYPLTNT RKQSLVSDLS RLGTSELSSD YAEHPHAYHG KSDYSSDASE
GIKSPVSKLG EQLKGEESNK FVLGRRLSSM SPKRSPDIPK LAAALKIHRQ RNENNRESEI
ESSAIEEEEE DEEEDDDKFN DDEDFKGPAT TKDNTIHSIP ILNKREARTS FIDTFMTNEN
SPDAFHNVPY LNKNQSPGYG YSSPKNKNGP SHSFANTPSK LAFLKKLSPR TMSSHSVTRA
PSSDWHVEHD PTLQVPPPEK KGAPDNLPPW NTTKLLRQIH ANALEMGNVI LAVNVLILFQ
DVYNIAPISI VKESVVHFVR LLHQYELFEI AAAILKYCPW DDLLGPEGDQ STVEIFCERC
GELITNEQGK DLPHGYWYCQ ACSRTNTLCV VCNTPLRKLT MAALKCGHEG HFECFTQWFI
TEGMSECPAG CTAALL
