RTC1_KLULA
ID RTC1_KLULA Reviewed; 1321 AA.
AC Q6CME1;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 119.
DE RecName: Full=Restriction of telomere capping protein 1;
GN Name=RTC1; OrderedLocusNames=KLLA0E20967g;
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: May be involved in a process influencing telomere capping.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Vacuole {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat RTC1 family. {ECO:0000305}.
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DR EMBL; CR382125; CAG99985.1; -; Genomic_DNA.
DR RefSeq; XP_454898.1; XM_454898.1.
DR AlphaFoldDB; Q6CME1; -.
DR STRING; 28985.XP_454898.1; -.
DR EnsemblFungi; CAG99985; CAG99985; KLLA0_E20967g.
DR GeneID; 2894643; -.
DR KEGG; kla:KLLA0_E20967g; -.
DR eggNOG; KOG0269; Eukaryota.
DR HOGENOM; CLU_008512_0_0_1; -.
DR InParanoid; Q6CME1; -.
DR OMA; GGRDGKC; -.
DR Proteomes; UP000000598; Chromosome E.
DR GO; GO:0097042; C:extrinsic component of fungal-type vacuolar membrane; IEA:EnsemblFungi.
DR GO; GO:0035859; C:Seh1-associated complex; IEA:EnsemblFungi.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:1904263; P:positive regulation of TORC1 signaling; IEA:EnsemblFungi.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR037590; WDR24.
DR InterPro; IPR001841; Znf_RING.
DR PANTHER; PTHR46200; PTHR46200; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding; Reference proteome; Repeat; Vacuole; WD repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..1321
FT /note="Restriction of telomere capping protein 1"
FT /id="PRO_0000408784"
FT REPEAT 109..148
FT /note="WD 1"
FT REPEAT 174..215
FT /note="WD 2"
FT REPEAT 223..263
FT /note="WD 3"
FT REPEAT 271..323
FT /note="WD 4"
FT REPEAT 327..366
FT /note="WD 5"
FT REPEAT 403..450
FT /note="WD 6"
FT REPEAT 453..491
FT /note="WD 7"
FT REPEAT 797..837
FT /note="WD 8"
FT REPEAT 1108..1151
FT /note="WD 9"
FT ZN_FING 1274..1316
FT /note="RING-type; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 1..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 546..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 893..917
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 957..1069
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..78
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 975..993
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1006..1022
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1034..1069
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1321 AA; 147003 MW; DD644CF8EFB04AA3 CRC64;
MFKRGSNRAT SSSQGQQPEN PPSLKYQSSS SRYSFHRQYN TGFGTSPFRI SPKYKPDSRT
PFSFDGTGNV GPESSLNEEE SNARWRPSES SFDKRRTFHG AKYSLSIGKE VSSIDKINSP
ESRSLIIAGK SHLGIYTFDE DSKTITNVHD FLQTAKTNTG ITKNTSSTLR RTTKKISTIS
DVKAGFYNHK NYVAICGTST SVAIYDINKT SAIDNPVVTS LSEHTRSINS VDFNMVQTSL
LISGGQDGCI KIWDLRSPKI STTRSDVSIN TGSDSIRDVK WMPSYEFSND TNGLSNRHFK
FASVHDSGLL LKFDLRQPNQ AEKKINAHSG PALCLNWHPH QDYIISGGRD GKCCLWYVGD
KSNQVGNISS TNLNSSNPAT HNLSSSYPLG LSNTLAFPEL TINTARSMNK LKFRPKYETN
VFNSLIGTSS MGEDSDVSVY SLARKYIPKN VIASSAPSVG FVWWDDDTIF NIDKQNTVTG
WDISHEPTVL DNLPKNTIKW RDLDGDGILF LDQKPGGYLS QEETVLTPGS GENRKMPFTH
RMSSATANSF TGGNNPNITS NTSSSAASFS KNPTLGMSQL HQGNVLGERS TMSKHAQSVN
SKFSPSVNSS PWTNPYSSPH HNSIVSGSES ALHAVNDSFL QSPYLIGLDF PHILNTIRNT
RLAEFNRKVE SAALLELKSS PTEVFKFLAR ELKFSYKYNS IETKDNGREL DSSSTHGSVD
SKTNLMEKLG LSENNTWTHL IKYTKSHDSD EVISKGTELK TPVSDKSANI EKSATNHKAE
TNQDENSSCI NSSNQVKTKN LIELITLCDK NAEIYIMLED FSNYKIWLLM RDSLLWDLKV
LTESMAVDVT ADQEVNDQSS IDQPWKKNDS FTSLKEARQA SVASGYSSYS ATDLSSSVNT
NNRHSFNEPT HLTQTPPVSH LKAQLQGSKE TTTISRADSI QNSLQNDIIE IRKLRQSHGD
RAELAIDEEE EGEEREELTK RAFEEDENNK QFINIPRRES GPSALMPSPS HVSSQSEIPS
NPENHHQPRR PRTSFIDSFM SQLRSPGSSN VDADRESTGS KKSSMPSFSS SAATFLNSKK
SQNANHNKLK SATEVSDILE SEFATQKSWN GSVAKTTTQM SGITALMNET KKLENTITPP
WSSRRLIHQL YEQSVASGNI LLTMAILLLF QDMFQLVDTE TVKNSIAEFT ELLHRYELFE
IAAELMKNCP YEDISSSSAG FSSIQLFCDK CNKPLVNESS KEKIIKERLE GNSSAMSRFG
YWYCDSCSKR NTLCCFCNKP MKSLAISMLN CGHEGHFECL KKWFFDENMD VCPLGCPAIL
F
