RTC1_LACTC
ID RTC1_LACTC Reviewed; 1290 AA.
AC C5DJV1;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=Restriction of telomere capping protein 1;
GN Name=RTC1; OrderedLocusNames=KLTH0F19338g;
OS Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS (Yeast) (Kluyveromyces thermotolerans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Lachancea.
OX NCBI_TaxID=559295;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284;
RX PubMed=19525356; DOI=10.1101/gr.091546.109;
RG The Genolevures Consortium;
RA Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT "Comparative genomics of protoploid Saccharomycetaceae.";
RL Genome Res. 19:1696-1709(2009).
CC -!- FUNCTION: May be involved in a process influencing telomere capping.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Vacuole {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat RTC1 family. {ECO:0000305}.
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DR EMBL; CU928170; CAR24590.1; -; Genomic_DNA.
DR RefSeq; XP_002555027.1; XM_002554981.1.
DR AlphaFoldDB; C5DJV1; -.
DR SMR; C5DJV1; -.
DR STRING; 559295.C5DJV1; -.
DR EnsemblFungi; CAR24590; CAR24590; KLTH0F19338g.
DR GeneID; 8293263; -.
DR KEGG; lth:KLTH0F19338g; -.
DR eggNOG; KOG0269; Eukaryota.
DR HOGENOM; CLU_008512_0_0_1; -.
DR InParanoid; C5DJV1; -.
DR OMA; GGRDGKC; -.
DR OrthoDB; 590848at2759; -.
DR Proteomes; UP000002036; Chromosome F.
DR GO; GO:0005773; C:vacuole; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032008; P:positive regulation of TOR signaling; IEA:InterPro.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR037590; WDR24.
DR InterPro; IPR001841; Znf_RING.
DR PANTHER; PTHR46200; PTHR46200; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding; Reference proteome; Repeat; Vacuole; WD repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..1290
FT /note="Restriction of telomere capping protein 1"
FT /id="PRO_0000408785"
FT REPEAT 162..203
FT /note="WD 1"
FT REPEAT 211..251
FT /note="WD 2"
FT REPEAT 259..314
FT /note="WD 3"
FT REPEAT 318..357
FT /note="WD 4"
FT REPEAT 397..444
FT /note="WD 5"
FT REPEAT 447..485
FT /note="WD 6"
FT REPEAT 778..819
FT /note="WD 7"
FT REPEAT 821..842
FT /note="WD 8"
FT REPEAT 1079..1119
FT /note="WD 9"
FT REPEAT 1166..1205
FT /note="WD 10"
FT ZN_FING 1243..1285
FT /note="RING-type; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 1..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 732..774
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 856..924
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 960..984
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1004..1034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..772
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 856..884
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1016..1034
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1290 AA; 142913 MW; 86AA2BF319A19012 CRC64;
MSRSQSPSLN DGLSTSNSRH SSSHSRFSLH KAFPQLSGNA SFNGTSPKTK LPSRFSGGSN
PPYMDSLKEQ ESSSSSSRSN FRRANYVNPG RIRSSGLKYS LQAPKELSSI DKINDPASRS
IVISGKNHLG LYRFREDYGK LELTLDLFNI DQKAASLRTT TRKTSTISDV KAGFHNYKNY
VAICGTSTSV SIYDINRANL VDGPASMVLS KHTRSINSVD FNMAQTSLLI SGSQDGCIKV
WDLRSSQGRK NKSDLTINSG SDSVRDVKWM PTYDFPNNDD VVAGPSNRSH RFASIHDSGL
LLTYDLRQPS QAEKRINAHS GPGLCLSWHP TLDYIMTGGR DGKCCLWNMG SKPLNPASFQ
NIHHNSSFST SAASSFTQGF SANSVTNFIN SPEAVVNTAH PLTKLKFRPS AIPEVFDSVI
ALSSLGENSD VSLYSLSRSY IPKNVLTTNS PSCGFVWWNE NLIFNIDKQN MVTGWDLGKE
PTVLDNLPKN KIAWRDIEGD GLVFLAQDKG GYESGGPDGM SVSTETRNFS QSRLSTTTMS
NLFPSHTMRQ NSSVSSFPAL NTHSNSGANL GDRPSLPRTV TSYSKGAYTQ TYGSYNTHSS
HHNSAASASA SSIATELGSE HVLSPRMISL DLPHILNSIR SAKIENYAKK PSRPGSAAFK
DSPVEVFKFL SRELKFSYMH DRNFNKPENL TDQDDLAQSV DDNDLKSHLI TRFGFSENNT
WTKFIKKSNS PEKDAAVENG TKVNEASIEK VTNSPNDTGS DELSSISKLS TEPKKSDLAE
RNITAIRQRV KHFIELVSMC DHNAEIYLYI DDLSNFKIWM MMRDSLLWEL KQITDSLETD
GGSLLSESLL VNPDVTRHSN GARKQSMASD YSSFSTSEVG STTGVQALPE FRGPHSLSTP
PRATTSFGAK EPSSLKKRES TIDENLSETE IEAKGLPKED IKNLRNQISK HQIGDEVAIE
DEEEDKFEEK SSAGTDASNK NIPIIPSERK VSFVDQFINS MRSPKTLHGD FETDGSRMAN
SASTKRSSQP SFSSSLAGLI TRRLSDQSPK TKPKDLIYSK SSGSIAKNSS DLFDFQNVEG
NNSPRVLTQK SKISMLLKGL KKSETAPPWD ASRLIKKIFE QSVATGNVLL TISIILLFQT
TFKVTSTTVV KNALSEFINI LHKYELFEIA ANLLKFCPWD DILEAGNGQC TVRIYCERCK
KLLVNESSKE KFTEEWKRTG RQEVMKRFGY WYCDNCSKRN TLCVLCEQPL KKLTFCVLNC
GHEGHPECFK KWFMNEEMSE CPSGCSGFLL
