RTC1_LODEL
ID RTC1_LODEL Reviewed; 1163 AA.
AC A5E6M3;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Restriction of telomere capping protein 1;
GN Name=RTC1; ORFNames=LELG_05262;
OS Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC Lodderomyces.
OX NCBI_TaxID=379508;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL
RC YB-4239;
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA Birren B.W., Kellis M., Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- FUNCTION: May be involved in a process influencing telomere capping.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Vacuole {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat RTC1 family. {ECO:0000305}.
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DR EMBL; CH981532; EDK47081.1; -; Genomic_DNA.
DR RefSeq; XP_001523416.1; XM_001523366.1.
DR AlphaFoldDB; A5E6M3; -.
DR SMR; A5E6M3; -.
DR STRING; 379508.A5E6M3; -.
DR PRIDE; A5E6M3; -.
DR EnsemblFungi; EDK47081; EDK47081; LELG_05262.
DR GeneID; 5230638; -.
DR KEGG; lel:LELG_05262; -.
DR VEuPathDB; FungiDB:LELG_05262; -.
DR eggNOG; KOG0269; Eukaryota.
DR HOGENOM; CLU_008512_0_0_1; -.
DR InParanoid; A5E6M3; -.
DR OMA; GGRDGKC; -.
DR OrthoDB; 590848at2759; -.
DR Proteomes; UP000001996; Unassembled WGS sequence.
DR GO; GO:0005773; C:vacuole; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032008; P:positive regulation of TOR signaling; IEA:InterPro.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR037590; WDR24.
DR InterPro; IPR001841; Znf_RING.
DR PANTHER; PTHR46200; PTHR46200; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding; Reference proteome; Repeat; Vacuole; WD repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..1163
FT /note="Restriction of telomere capping protein 1"
FT /id="PRO_0000408786"
FT REPEAT 129..169
FT /note="WD 1"
FT REPEAT 175..214
FT /note="WD 2"
FT REPEAT 221..265
FT /note="WD 3"
FT REPEAT 274..313
FT /note="WD 4"
FT REPEAT 346..392
FT /note="WD 5"
FT ZN_FING 1114..1157
FT /note="RING-type; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 24..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 525..606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 833..881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..560
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 841..881
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1163 AA; 127473 MW; 8688B462438BDF27 CRC64;
MAQDSQGQQQ SLAKFAFNIY GTLGTPQSSN SPSANSSISS HKSSKRLSKN QLSNSYSRRL
TYNAERDVQA IGQLNCGIQI SHHISGNEPS HHAVIGGKNY LRLLCLNRDQ QQVLQEIDLL
DVKSIYRSRN PNKISSVNTI KTRENTIACG MSNGTISMYK VSPYGKGTLH AMLSDHRRTV
NSIDFIDSTD HIISGSQDGS IKLWDLRASP TKPVFNLQAN LHNDPIRACQ YSPHSVVRNK
TCILSVHDSG ALCKFDLRSG SGSNMYSPDR KWNLHAGPVL SLHIHPEKEY VATGGRDHKI
CVFNYSEGRS LRTTPENIIN TYGSILKVRW SSYLVNQGGR AGDGGGMGSM HTSTSFGDST
LALTNYDLAC LYLNDDPTVT IYNLNRKYIP KQIINPYSQK AISNFMWAQN EIQGRRIWTL
NKANQFMAYD LDSNFDTDIK RPLDDLPPIG MSWNDNDDFI WVNQAKDEFE ANFESMCDDE
QFLTDTAAAA TATSTAFTAS TSTNTAIAAE RASSFDLEDH DHKMAGSSLG TSPIERPSLT
RSYTHNPMSQ FMTKSPSPIL RSGTGVLDMT SPPSAGSALS TSTYTPRPKL ARNPSQTTQG
SAGSFGSTPA SSSFAIKYKS GASGPGVSGV PGGPGVPGVP GGPIGGSLRL NSMVKSPFAF
PVELPFNDEE AFKFLATEYL VTTPEGFTLA DTCLMNASVA HEVGAYQSSQ VWRVLAISLS
DEKTMNAAAA RMKTRTTLDN KNHVDEPDSA NADHFNAATN MSATTDPNIT AVSHTKHDQE
EDVDSFALKS IQSDLDNVVG SYNSNSTLSI KYGRNINPLS SVSSHGIAYH GNDVHSRTNS
MHHSRANSFN NTHSVRAGSS GADDHLSVHS QSNPLAIDST TSKRGDYELE NTNLMNSIFL
RSSPNSIGFG SSRSYSSLAS SPIDARRALP ERQVPPEPLE LNHDTSLILE KKQSNHSPKL
PKRSGLSIAL KNDDHHDCEN DYEDGTEAWS FKSLLKGALE YAASQGEITF VSTIAILFYE
LARDIITFDQ CLGWLGEYVE ILQRKCLFVE ATKIINFAPL DVAEKLKTLY AADTIRLYCS
HCLKLLTNEK SKRQTHGEFG YWYCDECLQR QLNCVFCNEP CKGLVVAISL KCGHRGHFGC
LKEWFIDEQN VECPGGCDVP IVV
