ID   RTC1_VANPO              Reviewed;        1313 AA.
AC   A7TR10;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Restriction of telomere capping protein 1;
GN   Name=RTC1; ORFNames=Kpol_1038p20;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: May be involved in a process influencing telomere capping.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Vacuole {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat RTC1 family. {ECO:0000305}.
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DR   EMBL; DS480467; EDO15313.1; -; Genomic_DNA.
DR   RefSeq; XP_001643171.1; XM_001643121.1.
DR   AlphaFoldDB; A7TR10; -.
DR   STRING; 436907.A7TR10; -.
DR   PRIDE; A7TR10; -.
DR   EnsemblFungi; EDO15313; EDO15313; Kpol_1038p20.
DR   GeneID; 5543372; -.
DR   KEGG; vpo:Kpol_1038p20; -.
DR   eggNOG; KOG0269; Eukaryota.
DR   HOGENOM; CLU_008512_0_0_1; -.
DR   InParanoid; A7TR10; -.
DR   OMA; GGRDGKC; -.
DR   OrthoDB; 590848at2759; -.
DR   PhylomeDB; A7TR10; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0005773; C:vacuole; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0032008; P:positive regulation of TOR signaling; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR037590; WDR24.
DR   InterPro; IPR001841; Znf_RING.
DR   PANTHER; PTHR46200; PTHR46200; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 3.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   Metal-binding; Reference proteome; Repeat; Vacuole; WD repeat; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..1313
FT                   /note="Restriction of telomere capping protein 1"
FT                   /id="PRO_0000408788"
FT   REPEAT          180..221
FT                   /note="WD 1"
FT   REPEAT          229..269
FT                   /note="WD 2"
FT   REPEAT          339..378
FT                   /note="WD 3"
FT   REPEAT          442..484
FT                   /note="WD 4"
FT   REPEAT          711..752
FT                   /note="WD 5"
FT   REPEAT          795..837
FT                   /note="WD 6"
FT   REPEAT          1100..1143
FT                   /note="WD 7"
FT   REPEAT          1190..1229
FT                   /note="WD 8"
FT   ZN_FING         1267..1309
FT                   /note="RING-type; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          38..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1313 AA;  147070 MW;  A0CC5F21C756C7A7 CRC64;
     MSNYSCPRTH NKSNMSGRNE VKPISFSRGS FQIHHYSNSI HSPSLDGSPR QNFSQKYSFG
     SINSSNSSYD RSRDPSSVEQ QLMREKSQAL LKRKSSPMPK SSGLLYSTHT NKELSSIDKI
     NDPSSNALIC AGKAHLGYYK FSSNDNNKIT LVHEFTQGFS SGSSQLNSLN PNLNKRRRQI
     KLSTIADVKS GFQKYNNYIA VCNNSTIISI YDINKNDNID NPLVTSFSEH SRAVNSFDFN
     MTQTSLLISG GQDGQIKIWD LRSNSLSGSN KPDLNINAAS DSIRDVKWMP GYNFSSFNQS
     YDGKQTGNSE YKFASIHDSG LLLKFDIRQP NQVEKKINAH TGPGLCLNWH PNQDYIATGG
     RDGKCCIWYI GDVVNDAPVT SLGSMTPNTL HTSNVNYYQS NATSLALPEM TINTGFPVTK
     LKFRPAYEKN VMDSLLAISS MGEEAEVNIY SLCRKFIPKH VLLTTSPSQG LVWWDKSLIF
     NTDRSNRING WDIDLEPTVL DNLPKALATW RDIDGNGLLV IDQDSGTYTA NEEYIPLVFD
     KRRRQSHRLL NPSINDNNSI TKTKYLDSIK KANSNTIISP TSVEKTGNIK QPNLHSNKSI
     IGMTSPMYMT QFMPPTNSPS PLNEPLEFKG IQSPLIVALD FPHILNNMRL SKITSKKHLS
     KSSDIAAIKE SPIQVFQYLA RELEFSFSKD RKLDSRSSII KRKSISDDSG SQVDVIKKIG
     FTDTTKWTNL INRKTDGEIA EKSSDRISAL STSSESIKND IDEKSEHSKN NAYLNLEKKL
     SHGTHGMPED AIEAQHKVDI LIELVTICSH NASVYSYIDD VPNFKIWTLI KDSLLWDLKD
     ITGIEEAINS NDSIEIKDKF QYFENLDHER ALKNSSSQTQ FSDIPSEIES FVTENPEALT
     SASLELDNDI EEGTKESKRP ISNLQQQLKA ENTAVMDTPS DVFVTATTDG GHFRDNSKVT
     RDENKIETND NTNLLNIGKV NTENAIKIDS ESVIEDVAPG SKSIEIPTLT RGRTRTSFID
     TFMTNPLHNM ERPDRSLLLA QDSAASLNDQ SSPISKVSSI KSSSNVPHSL NSMIKLSQGK
     MHSRTRSIGK SPIKLSGFLS PKERSLSLPL ENILKKNKSA EKVAHNDQFR PPWETGKLLK
     QLFNQAVETG NILLAINIIT LFQDLYNITT IDVVKSSLLQ FVEILHRYEL FEIATALLKY
     CSWNNILEGN GGNSTVQLFC DKCGKLIVNE FSKTNFNEEL KRTGNKDSMK KFGYWYCDAC
     KKPNSLCVLC EKPMKKLVMC VLACGHEGHF QCLRDWFLNE GMNECPAGDI QVI