ID   RTC1_ZYGRC              Reviewed;        1273 AA.
AC   C5DSV0;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Restriction of telomere capping protein 1;
GN   Name=RTC1; OrderedLocusNames=ZYRO0C03190g;
OS   Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568
OS   / NRRL Y-229) (Candida mogii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Zygosaccharomyces.
OX   NCBI_TaxID=559307;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2623 / CBS 732 / BCRC 21506 / NBRC 1130 / NCYC 568 / NRRL
RC   Y-229;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: May be involved in a process influencing telomere capping.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Vacuole {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat RTC1 family. {ECO:0000305}.
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DR   EMBL; CU928175; CAR26861.1; -; Genomic_DNA.
DR   RefSeq; XP_002495794.1; XM_002495749.1.
DR   AlphaFoldDB; C5DSV0; -.
DR   STRING; 559307.C5DSV0; -.
DR   EnsemblFungi; CAR26861; CAR26861; ZYRO0C03190g.
DR   GeneID; 8202989; -.
DR   KEGG; zro:ZYRO0C03190g; -.
DR   HOGENOM; CLU_008512_0_0_1; -.
DR   InParanoid; C5DSV0; -.
DR   Proteomes; UP000008536; Chromosome C.
DR   GO; GO:0005773; C:vacuole; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0032008; P:positive regulation of TOR signaling; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR037590; WDR24.
DR   InterPro; IPR001841; Znf_RING.
DR   PANTHER; PTHR46200; PTHR46200; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 3.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   Metal-binding; Reference proteome; Repeat; Vacuole; WD repeat; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..1273
FT                   /note="Restriction of telomere capping protein 1"
FT                   /id="PRO_0000408793"
FT   REPEAT          119..164
FT                   /note="WD 1"
FT   REPEAT          166..207
FT                   /note="WD 2"
FT   REPEAT          215..255
FT                   /note="WD 3"
FT   REPEAT          327..366
FT                   /note="WD 4"
FT   REPEAT          448..486
FT                   /note="WD 5"
FT   REPEAT          639..679
FT                   /note="WD 6"
FT   REPEAT          784..824
FT                   /note="WD 7"
FT   REPEAT          1058..1101
FT                   /note="WD 8"
FT   ZN_FING         1225..1267
FT                   /note="RING-type; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          69..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          521..559
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          741..777
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          839..861
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          880..971
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        528..559
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        746..777
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        880..897
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        899..913
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1273 AA;  140762 MW;  E36A7D1C24EB7EF6 CRC64;
     MNNRPIPRNQ ASSSLGRNDL KPGLFGRSSF RVQHYSGTNG ISPIGSSPRT KISPRYSFAS
     SFATSESSLR ESSYFDERPP VQDTGVPKSS GLYYSRASPK ELSSIDRIND SSFNGIVCAG
     KTHLGLYKFS PQDKSIDCMH DFVSAGNDGN RGSNVQMGLG KRSKRTKLST IADVKAGFHN
     HKNYVAICSN STVLSIYDIN KTGSIDNPLV TNCSQHVRSV NSFDFNMVQT NLIISGGQDS
     CIKIWDLRSS RSRTLSRADV NINTASDSIR DVKWMPHPTA CRSASQNDLR SGVGGAAGYK
     FASIHDSGLL LKFDLRQPNQ VEKRINAHSG PGLCLNWHPY QDYISTGGRD GKCCLWYVGD
     GKPGTDFLQA GNTSVNTPHS MTSNLPTNLS VVPDMTINCG FPVTKLKVRP CYEKNVLNSL
     VSMSSMAEDF GVSIYSLARK YIPKYNLSTS SASLGFVWWD DNLIFNIDKD NRINGWYLDR
     EPTVLDNMPK IVTRWRDIEG NGLLFIDQDR GGYQVNDEVP ANIEESKKPP NQRVSINSLS
     GTAGGGNSGG GSNSGMIGSI KKGISQTGLT SFAGERPALS KTGLNFSNKS LATQSMNNSH
     SNSFSSYAGA GPGPLNEVAD YSGIESPFLM TIDLPYILNN MRVSQLPPER KSLYSPEVQA
     IRESPVKVFK FLAKELEFSY MQEGRSGEMK NATQLSNVNE DTTKKDLMVK FGISEKSTWT
     ALVNKKNEAV EAISKKSVST KEGSESLIES DGESSAKSHE SDDNSSDADK KENAKDGTMH
     VQEKIDILLE LIPICGHNAS VYSYIDDLPN FKIWILIRDS LLWDLERLSV EYPDEKLPET
     QSTDQIGQPI TMGNDDSLAS DTRSYMTSDL NYFVEEHPRA LRSDSDEPKD HKKPLSGLKS
     QLTKIQETEA SIDDSLNPPK MLKKPDNPIK QEQIGSRLND DSDSAVLEDD DNEEKSDFDT
     QIKGIPITNK RQPRQSFIDT YMGGLKSPIG SSNANNEFFM GRVGHSLGHS SPGSKGSPMA
     SLNNGEFTYP GFKRMSSRND RRSSGSLFLS PLKRRESSTA EFFNKSPMRP LSPVAPVSSF
     KSNPTEFLPP WNTRRLLKQI FKQAVEMGNI LLVVNILFLF QNLYQLTSTE VLKNTLAQFI
     KILHKHELFE LSAAILKCSP WEVVINADGG QSLVPIFCDK CGKLITNEPS KEKFTLEAQE
     KGNSMPLQRF GYWYCDSCKK PNTLCVFCER PIKTLAIGLL ECGHEGHFQC LQSWFLDEGM
     AECPGGCMNQ IRL