ID   RTC5_AJECH              Reviewed;         682 AA.
AC   C6H208;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 1.
DT   03-AUG-2022, entry version 33.
DE   RecName: Full=Restriction of telomere capping protein 5;
GN   Name=RTC5; ORFNames=HCDG_00740;
OS   Ajellomyces capsulatus (strain H143) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=544712;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H143;
RA   Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M.,
RA   Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S.,
RA   Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA   Yandava C., Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S.,
RA   Nino-Vega G., San-Blas G., Taylor J.W., Mendoza L., Galagan J.E.,
RA   Nusbaum C., Birren B.W.;
RT   "The genome sequence of Ajellomyces capsulatus strain H143.";
RL   Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in a process influencing telomere capping.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RTC5 family. {ECO:0000305}.
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DR   EMBL; GG692419; EER45161.1; -; Genomic_DNA.
DR   AlphaFoldDB; C6H208; -.
DR   SMR; C6H208; -.
DR   STRING; 544712.C6H208; -.
DR   EnsemblFungi; EER45161; EER45161; HCDG_00740.
DR   VEuPathDB; FungiDB:HCDG_00740; -.
DR   eggNOG; ENOG502QV3R; Eukaryota.
DR   HOGENOM; CLU_011918_1_0_1; -.
DR   OMA; SHHVLTW; -.
DR   Proteomes; UP000002624; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006571; TLDc_dom.
DR   Pfam; PF07534; TLD; 1.
DR   SMART; SM00584; TLDc; 1.
DR   PROSITE; PS51886; TLDC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..682
FT                   /note="Restriction of telomere capping protein 5"
FT                   /id="PRO_0000408805"
FT   DOMAIN          369..605
FT                   /note="TLDc"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01234"
FT   REGION          166..200
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          331..357
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        170..189
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   682 AA;  73762 MW;  F25F1599B2119F7E CRC64;
     MGGALSTDGA EQRASSVEEL NQRLAHRFAA KCFEPLELTH LKENFFSRAL DQHGIRYWNE
     EILSEFLGIP DGAGSAAAAT SDGSLDAGPV IFRMVSYLGA FPFQNTMAPT VLTFESMVKV
     VVLLTERYGK VLKRGKKDRM KLLFGSLADV GRRDIITVLK EATEDSLESI GPSDPRSASP
     STHNTGFLVD QPVNDEDEED DDDLAIAALE SLDAIEVFKH DQRIDKTVYE SKISLTTFRR
     LLTLLLVTAP LRPLGRVSKF TTGLSKPSLD AVHEQVDSIL AALDPGEASD GIGYKSFSKL
     VSTSLPYLFD PLTPLFEHLL FSKNLDLSRK RDSQTTNGLT SKPVPTPPST PPLSPPLSPV
     ISTGGFDSCI LNPALLSHLS FFVSTNVHIP NIFRNRTHLH PVFSSTEHGE SLTSFSHHVM
     TWQAPSILLV RGAVVSESSE EQLTTIGAYL PQPWKQTSSY SSRRSSEAPD PSTLPCLFEL
     SPVHTVLQGS PSFSSLKSNM PVTHFSTKTG IAIGCMIPPS SRKSFGSDLH PKPAGGGSLL
     IDSALENATF IVSNGLNGPG VFLPPGISPV LSSTSLTASV PSMSSSNQNF TKSISIYNLE
     VWGIIPSTSL ATQLDGSGSP IEKRDAISLQ RAQWDFEARE AERRQAINMK VGGGESDAQT
     GRALLEMAGI IGDSYYSGHH RH