ID   RTC5_AJECN              Reviewed;         682 AA.
AC   A6RBC0;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Restriction of telomere capping protein 5;
GN   Name=RTC5; ORFNames=HCAG_06258;
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma;
OC   unclassified Histoplasma.
OX   NCBI_TaxID=2059318;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- FUNCTION: May be involved in a process influencing telomere capping.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RTC5 family. {ECO:0000305}.
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DR   EMBL; CH476661; EDN10455.1; -; Genomic_DNA.
DR   RefSeq; XP_001538653.1; XM_001538603.1.
DR   AlphaFoldDB; A6RBC0; -.
DR   SMR; A6RBC0; -.
DR   STRING; 339724.A6RBC0; -.
DR   EnsemblFungi; EDN10455; EDN10455; HCAG_06258.
DR   GeneID; 5444813; -.
DR   KEGG; aje:HCAG_06258; -.
DR   VEuPathDB; FungiDB:HCAG_06258; -.
DR   HOGENOM; CLU_011918_1_0_1; -.
DR   OMA; SHHVLTW; -.
DR   OrthoDB; 714794at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006571; TLDc_dom.
DR   Pfam; PF07534; TLD; 1.
DR   SMART; SM00584; TLDc; 1.
DR   PROSITE; PS51886; TLDC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..682
FT                   /note="Restriction of telomere capping protein 5"
FT                   /id="PRO_0000408806"
FT   DOMAIN          369..605
FT                   /note="TLDc"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01234"
FT   REGION          167..198
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          331..358
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        175..189
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        344..358
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   682 AA;  73863 MW;  F79DE204160B853F CRC64;
     MGGALSTDDP EQRASSVEEL NQRLAHRFAA KCFEPLELTH LKENFFSRAL DQHGIRYWNE
     EILSEFLGIP DGAGSAAAAT SDGSLDAGPV IFRMVSYLGA FPFQNTMAPT VLTFESMVKV
     VVLLTERYGK VLKRGKKDRI KLLFGSLADV GRRDIITQLK EATEDSLESI GPFDPKSASP
     STHNTGFLVD QPLNDEDEED DDDLAIAALE SLDAIEVFKH DQRIDKTVYE SKISLTTFRR
     LLTLLLVTAP LRPLGRVSKF TTGLSKPSLD AVHEQVDSIL AALEPGEASD GIGYKSFSKL
     VSTSLPYLFD PLTPLFEHLL FSKNLDLSRK RDSQTTNGLT NKPVPTPPST PPISPPLSPV
     ISTGGFDSRI LNPAVLSHLS FFVSTNVHIP NIFRNRTHLH PVFSSTEHGE SLTSFSHHVM
     TWQAPSILLV RGAVVSESSE EQLTTIGAYL PQPWKQTSSY SSRRSSEVPD PSTLPCLFEL
     SPVHTVLQGS PSFSSLKPNM PVSHFSTKTG IAIGCVIPPS SRKSLGSDLH PKPAGGGSLL
     IDSALENATF IVSNGLNGPG VFLPPGISPV LSSTSLTASV ASMSSSNQNI TKSISIYNLE
     VWGIIPSTSL ATQLDGSGSP IEKRDAISLQ RAQWDFEARE AERRQAINMK VGGGEADVPT
     GRALLEMAGI IGDSYYSGHH RH