ID   RTC5_KLULA              Reviewed;         572 AA.
AC   Q6CMD3;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Restriction of telomere capping protein 5;
GN   Name=RTC5; OrderedLocusNames=KLLA0E21143g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: May be involved in a process influencing telomere capping.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RTC5 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR382125; CAG99993.1; -; Genomic_DNA.
DR   RefSeq; XP_454906.1; XM_454906.1.
DR   AlphaFoldDB; Q6CMD3; -.
DR   SMR; Q6CMD3; -.
DR   STRING; 284590.Q6CMD3; -.
DR   PRIDE; Q6CMD3; -.
DR   EnsemblFungi; CAG99993; CAG99993; KLLA0_E21143g.
DR   GeneID; 2894637; -.
DR   KEGG; kla:KLLA0_E21143g; -.
DR   eggNOG; ENOG502QV3R; Eukaryota.
DR   HOGENOM; CLU_011918_1_0_1; -.
DR   InParanoid; Q6CMD3; -.
DR   OMA; SHHVLTW; -.
DR   Proteomes; UP000000598; Chromosome E.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006571; TLDc_dom.
DR   Pfam; PF07534; TLD; 1.
DR   SMART; SM00584; TLDc; 1.
DR   PROSITE; PS51886; TLDC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..572
FT                   /note="Restriction of telomere capping protein 5"
FT                   /id="PRO_0000408826"
FT   DOMAIN          288..520
FT                   /note="TLDc"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01234"
SQ   SEQUENCE   572 AA;  65241 MW;  2622B9565FA623B5 CRC64;
     MGQSTSKEHE NARTNESKLK GESLMDFFND RCLKQLTTAE LISFKNNIPE GKELNDYVEV
     SDISRMYYIP KDSAVMLSVF MNMFHTLANF PLLQDSYEKV TFKTLLKATL LLVKERAIKY
     TDWKKYNDLK MLFITLSLEK NIKAEPLMDS SALSDCKDWK GVIRSYNGTD FDELKVNANN
     LLHFLALILA LSRCCILNNC KIDNDVLAKS LEDFKHQALN IVRTMNPEII SMSDCLDSSI
     TYTQFSMAVN DVAPNLLNPL KMLMEHVLYM DRDLVDADVL QPISNPTKIV NESELSQLAT
     FLPKEIVFSR FQKLYVGRES GFSMRSFQSK VFKWMAPTIL FVEGMRIRDE DDEDGDAYAV
     KNPRYRNFLQ EYGKLKSEDQ HLDTLSKKKR KLLFAVCIRD PWKVSNKDLF GDSSTKIIQL
     HPRQEIFDAD PFKTGNVYFN TVGGGIGIGS SQPIIKANGK KYFPGNVSLT IDSSLEFGIF
     RHLGAGGSFK PGRLISGRGE ERNSFEYRFI IQDVEVWGCG GEKELEEQVK QWQWEEAEAK
     RRQKINLQSM GEDRALLEMA GLVGQHQSGG SI