ID   RTC5_NEUCR              Reviewed;         599 AA.
AC   Q7S454;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   19-MAR-2014, sequence version 2.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Restriction of telomere capping protein 5;
GN   Name=rtc5; ORFNames=NCU02452;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: May be involved in a process influencing telomere capping.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RTC5 family. {ECO:0000305}.
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DR   EMBL; CM002242; EAA30271.2; -; Genomic_DNA.
DR   RefSeq; XP_959507.2; XM_954414.3.
DR   AlphaFoldDB; Q7S454; -.
DR   SMR; Q7S454; -.
DR   STRING; 5141.EFNCRP00000008502; -.
DR   EnsemblFungi; EAA30271; EAA30271; NCU02452.
DR   GeneID; 23568387; -.
DR   KEGG; ncr:NCU02452; -.
DR   VEuPathDB; FungiDB:NCU02452; -.
DR   HOGENOM; CLU_011918_1_0_1; -.
DR   InParanoid; Q7S454; -.
DR   Proteomes; UP000001805; Chromosome 7, Linkage Group VII.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR013902; DUF1773.
DR   InterPro; IPR006571; TLDc_dom.
DR   Pfam; PF08593; DUF1773; 1.
DR   Pfam; PF07534; TLD; 1.
DR   SMART; SM00584; TLDc; 1.
DR   PROSITE; PS51886; TLDC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..599
FT                   /note="Restriction of telomere capping protein 5"
FT                   /id="PRO_0000408833"
FT   DOMAIN          318..544
FT                   /note="TLDc"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01234"
SQ   SEQUENCE   599 AA;  66841 MW;  9E4387733B602D3E CRC64;
     MGQVLSEERK PAPLSHEELV KELANIFADK CFTPLELYSL KQVFKSLAHH EQHVGYLKEG
     TIATYLNVPD ILGVSPVLFQ MVTYIAAFPF LEDAPAFLGL QQMVIVITLM TDRYRRVLRK
     DAADKTKLLF KSLAVYDRKL SRPAADMHSG LTNAREQAGN DRQALDNDEL VLAAFDALGH
     VIPDKQQNML ATHEAMIPGD KFRKFIMLLL LVAPLDPQGR LDSDPNRVTG TGLQCLRTAA
     ESILAAFLDV ERKPGVEYLR FSKVIASCLP FLFRGLTPLF EYFLFSEELD FHKGKKGTSR
     SPTMFPEPEQ PILQDTGSIM NASILSQMSF FLPGNLLFRR LRLLYAGDED GFSMGSFEAK
     VFKWKAPTIL LVCGTRLRDD SDHHSNGSAP AFWASLPPRR FPRGSSGEAE RLTFGVYVPE
     PWKLTHRDCF GGEDTILFQL EPIHDLFRAS SLNKDHISFA RPSASPSHAG VSFGCPPPRP
     SQAYRRSSII ALGPVSLMLD SSFEFGCFTH DYASKGGAFH TSMIREYDFQ ERFEIGSVEV
     WGCGGDEEAK DQAERWAWEA REAEARRRIN LGTGDIEADR ALLEMAGLIG SNRNGGSMA