ID   RTC5_YEAST              Reviewed;         567 AA.
AC   Q12108; D6W2H7;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Restriction of telomere capping protein 5;
GN   Name=RTC5; OrderedLocusNames=YOR118W; ORFNames=O3263, YOR3263w;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 96604 / S288c / FY1679;
RX   PubMed=9200815;
RX   DOI=10.1002/(sici)1097-0061(19970615)13:7<655::aid-yea120>3.0.co;2-i;
RA   Voss H., Benes V., Andrade M.A., Valencia A., Rechmann S., Teodoru C.,
RA   Schwager C., Paces V., Sander C., Ansorge W.;
RT   "DNA sequencing and analysis of 130 kb from yeast chromosome XV.";
RL   Yeast 13:655-672(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 96604 / S288c / FY1679;
RX   PubMed=8904341;
RX   DOI=10.1002/(sici)1097-0061(19960315)12:3<281::aid-yea904>3.0.co;2-o;
RA   Wiemann S., Rechmann S., Benes V., Voss H., Schwager C., Vlcek C.,
RA   Stegemann J., Zimmermann J., Erfle H., Paces V., Ansorge W.;
RT   "Sequencing and analysis of 51 kb on the right arm of chromosome XV from
RT   Saccharomyces cerevisiae reveals 30 open reading frames.";
RL   Yeast 12:281-288(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169874;
RA   Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA   Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA   Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA   Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA   Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA   Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA   Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA   Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA   Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA   Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA   Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA   Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA   Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA   Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA   Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA   Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA   Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL   Nature 387:98-102(1997).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [5]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [6]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [7]
RP   FUNCTION.
RX   PubMed=18845848; DOI=10.1534/genetics.108.092577;
RA   Addinall S.G., Downey M., Yu M., Zubko M.K., Dewar J., Leake A.,
RA   Hallinan J., Shaw O., James K., Wilkinson D.J., Wipat A., Durocher D.,
RA   Lydall D.;
RT   "A genomewide suppressor and enhancer analysis of cdc13-1 reveals varied
RT   cellular processes influencing telomere capping in Saccharomyces
RT   cerevisiae.";
RL   Genetics 180:2251-2266(2008).
CC   -!- FUNCTION: May be involved in a process influencing telomere capping.
CC       {ECO:0000269|PubMed:18845848}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}.
CC   -!- MISCELLANEOUS: Present with 2600 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the RTC5 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X94335; CAA64038.1; -; Genomic_DNA.
DR   EMBL; X90518; CAA62106.1; -; Genomic_DNA.
DR   EMBL; Z75026; CAA99316.1; -; Genomic_DNA.
DR   EMBL; BK006948; DAA10893.1; -; Genomic_DNA.
DR   PIR; S60985; S60985.
DR   RefSeq; NP_014761.1; NM_001183537.1.
DR   AlphaFoldDB; Q12108; -.
DR   SMR; Q12108; -.
DR   BioGRID; 34514; 31.
DR   DIP; DIP-5512N; -.
DR   IntAct; Q12108; 2.
DR   MINT; Q12108; -.
DR   iPTMnet; Q12108; -.
DR   MaxQB; Q12108; -.
DR   PaxDb; Q12108; -.
DR   PRIDE; Q12108; -.
DR   EnsemblFungi; YOR118W_mRNA; YOR118W; YOR118W.
DR   GeneID; 854285; -.
DR   KEGG; sce:YOR118W; -.
DR   SGD; S000005644; RTC5.
DR   VEuPathDB; FungiDB:YOR118W; -.
DR   eggNOG; ENOG502QV3R; Eukaryota.
DR   HOGENOM; CLU_011918_1_0_1; -.
DR   InParanoid; Q12108; -.
DR   OMA; SHHVLTW; -.
DR   BioCyc; YEAST:G3O-33647-MON; -.
DR   PRO; PR:Q12108; -.
DR   Proteomes; UP000002311; Chromosome XV.
DR   RNAct; Q12108; protein.
DR   GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR   InterPro; IPR006571; TLDc_dom.
DR   Pfam; PF07534; TLD; 1.
DR   SMART; SM00584; TLDc; 1.
DR   PROSITE; PS51886; TLDC; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..567
FT                   /note="Restriction of telomere capping protein 5"
FT                   /id="PRO_0000237657"
FT   DOMAIN          289..515
FT                   /note="TLDc"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01234"
SQ   SEQUENCE   567 AA;  64294 MW;  CC89D0F63C8F7401 CRC64;
     MGQSSSISSS NEEGSSHSKK FTNSKDILAY FNNKAQQQVT IPELVSFKGN LQIEDLNTPI
     SHKALCNSLY FPQNHAMIVG IVTNMLRVLS NFPLMKSSYE PITGYGLLKC ILLLNRARCA
     KFLKTKSYDQ LKLLFISLSL QKTDKEELSE ESENDGNKEL TIKQIITGFD DVDTEMLCIP
     ADFMLQFLTW LLILTVDCPT TNSKLDNTET HDQWGNFKVS ALNLLRTMNP DVVGDIESHS
     ITFQQFSTAI RTVMPNLLKP LENLMEHFFY LQHDLVDHDT NLSSIQDSKV MTPALLAQLS
     TGLPKELFIH KLQSLYIGRK SGFSMRSLQA KVFKWMAPSI LVVSGMRITN SEEYAAEKNP
     RYRHFLEEFP KLKESDQMMD ASHLNKRKTT FAVYIDDPWK VTNKDYFGDL NTRIIEISPR
     QDIYKVNQKG TIYFNTIGGG IGIGDKQPLI KPASKRYIPG NVSLTFDSTL EFAVFRNTGY
     GGSLDPGLLS MERKEENSPY ELHFLIQDVE VWGCGGEKEL EEQIKQLEWE EAESKRRQQI
     NLRSLGEDRA LLEMAGLVGQ HQGGGSM