ABCF4_DICDI
ID ABCF4_DICDI Reviewed; 1142 AA.
AC Q8T6B4; Q55FQ7;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=ABC transporter F family member 4;
GN Name=abcF4; ORFNames=DDB_G0267436;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR EMBL; AF479256; AAL87694.1; -; Genomic_DNA.
DR EMBL; AAFI02000003; EAL73170.1; -; Genomic_DNA.
DR RefSeq; XP_647476.1; XM_642384.1.
DR AlphaFoldDB; Q8T6B4; -.
DR SMR; Q8T6B4; -.
DR STRING; 44689.DDB0191119; -.
DR PaxDb; Q8T6B4; -.
DR EnsemblProtists; EAL73170; EAL73170; DDB_G0267436.
DR GeneID; 8616283; -.
DR KEGG; ddi:DDB_G0267436; -.
DR dictyBase; DDB_G0267436; abcF4.
DR eggNOG; KOG0062; Eukaryota.
DR HOGENOM; CLU_277633_0_0_1; -.
DR InParanoid; Q8T6B4; -.
DR OMA; NIVEICG; -.
DR Reactome; R-DDI-382556; ABC-family proteins mediated transport.
DR PRO; PR:Q8T6B4; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005829; C:cytosol; ISS:dictyBase.
DR GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR GO; GO:0006448; P:regulation of translational elongation; ISS:dictyBase.
DR GO; GO:1903013; P:response to differentiation-inducing factor 1; HDA:dictyBase.
DR GO; GO:0031288; P:sorocarp morphogenesis; IMP:dictyBase.
DR Gene3D; 3.40.50.300; -; 3.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR032781; ABC_tran_Xtn.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF12848; ABC_tran_Xtn; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Nucleotide-binding; Reference proteome; Repeat; Transport.
FT CHAIN 1..1142
FT /note="ABC transporter F family member 4"
FT /id="PRO_0000346859"
FT DOMAIN 604..857
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 923..1139
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT REGION 1..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..92
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..123
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..155
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..185
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..232
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..280
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..328
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..377
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..442
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..471
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..517
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..533
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..564
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 636..643
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 956..963
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 1142 AA; 130225 MW; 33B1815AB09942DC CRC64;
MGPKGKKKGQ SFDDSDEEIN NKKGGNKKGQ QLEDDIPQPV KKGGNKKGQR GKQDSDDEPE
NIPQPVAKKS NNKKGQRGKQ DSDDEQDEIP QPQKKGGKPA PQPQKKGGKQ QDSDDEQDEI
PQPVKKGGKP APQKKGGKQQ QQQDSDDEQE EIPQPVKKGG KPAPQKKGGK QQDSDDEEDE
IPQPVKKGGK PAPQKKGGKQ QESEDEDEED EVQQPVKKGG KNDKKKGVKH VEEEEEEEEE
EEIEQPVKKG GKAPKPKKGG KGSKQESEDE EDDVQQPVKK GGKKDKKKGS KHVEEEEEEE
EEEEIEQPVK KGSNKKDQKK GGKGKHVEEE EEEEEEEEIE QPVKKGSNKK DQKKGGKGKQ
QQESEDEEEE IQQPVKKGGK KDKKKGSKHV EEEEEEEEEE EEIEQPVKKG GKKDKKSSLE
DSMSELSIKS KKGGKGKHVE EEEEQEQEEE EEKPKSKSNK KDKKKGKHVE EEEEEEEEEE
EKPKSKSNKK DKKKGSKHIE EEEEEEEEEE EEEKEEEEEK KMTLAEIRAA KKVKKVDKKE
KKKEKEKKKR DEQEEDAFEL AKKKQQEEID YDNIDIDDVP GKDAPTYVHL KSSEGLRSKI
GNDIKFDNLI LSVPGRILLN NASLTLAYGQ KYGFVGRNGI GKSTLVKKIA MRDEITIAPH
LRVLYVEQEV TGDDTTPLDC VLAADEERKW LLDEEKVLTE LEKVNPSWQF DPRQKRNYSL
RDIYDRLKEI DADKASIRAA NILIGLGFTF EEISVKKSRD YSGGWRMRIA LARALFCKPE
VLLLDEPSNH LDLHACVWLE KYLNQWDRTL LVVSHEASFL NEVVDNIIYI HDQKLDQYRG
NYDAFMKQKS VNLRSKEKEK DKQDRKLKKM NEFITKNKNN TQAKQAASRA KKMEKIETIE
LEREDASLVV DFPQPEHLTP PLLVFKDVCF GYEGRPTMFK KLDIGIDMDS KIALVGMNGV
GKSTLMKLMN GDLHETTGYI ERSRKMRVAR FSQHFVDQLD TTMTPIEYFQ SKFNNPPVQQ
IRNHLGRFGI CNSLPLHKIT TLSGGQKSRV ILAELAWAEP HILLLDEPTN HLDIDAIEAL
AEGINAFTGG VVLISHNQHL INLIAEQIWV VKKDGTIYLY PGTFMDYKNE ISREIDNMVI
RS
